ENSG00000154380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358675 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding retained_intron 62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 17.552246 10.208125 29.302559 2.6310533 0.9096459 1.5203884 0.2839292 0.28400000 0.29563333 0.01163333 9.295329e-01 2.18132e-19 FALSE TRUE
ENST00000366843 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding protein_coding 62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 5.242875 4.123073 6.188021 1.1357619 0.1526497 0.5845928 0.1091958 0.11436667 0.06250000 -0.05186667 2.897891e-02 2.18132e-19 FALSE TRUE
ENST00000391874 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding processed_transcript 62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 9.660278 8.533626 12.072402 3.4952464 1.1520617 0.4999869 0.1369917 0.20906667 0.12130000 -0.08776667 7.219299e-01 2.18132e-19 FALSE FALSE
ENST00000497899 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding protein_coding 62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 5.707255 3.969344 7.000030 1.1151450 0.8810068 0.8168899 0.1296458 0.13513333 0.07096667 -0.06416667 7.941072e-01 2.18132e-19 FALSE TRUE
ENST00000635051 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding protein_coding 62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 5.935342 3.063889 10.079895 0.6976544 0.3508756 1.7147741 0.0900375 0.09023333 0.10166667 0.01143333 8.679699e-01 2.18132e-19 FALSE TRUE
MSTRG.3141.11 ENSG00000154380 HEK293_OSMI2_6hA HEK293_TMG_6hB ENAH protein_coding   62.56684 35.7645 99.12944 9.049347 3.23183 1.470528 12.388059 2.404741 27.572037 0.5494999 0.2749204 3.5137885 0.1664167 0.06920000 0.27866667 0.20946667 2.181320e-19 2.18132e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000154380 E001 0.0000000       1 225486765 225486828 64 -      
ENSG00000154380 E002 0.2027342 0.0348997605 2.187717e-01   1 225486829 225486834 6 - 0.000 0.176 11.659
ENSG00000154380 E003 990.2816935 0.0051385825 5.537392e-13 5.959753e-11 1 225486835 225495479 8645 - 2.851 3.136 0.947
ENSG00000154380 E004 1317.2715362 0.0027335704 3.713293e-02 1.472682e-01 1 225495480 225496884 1405 - 3.051 3.146 0.318
ENSG00000154380 E005 770.9370881 0.0001322006 5.368792e-02 1.883224e-01 1 225496885 225497422 538 - 2.847 2.864 0.059
ENSG00000154380 E006 426.9944785 0.0013086363 2.677532e-02 1.176196e-01 1 225497423 225497633 211 - 2.600 2.587 -0.044
ENSG00000154380 E007 438.0232600 0.0001316493 2.223154e-06 5.724681e-05 1 225497634 225497812 179 - 2.618 2.575 -0.146
ENSG00000154380 E008 311.9485699 0.0002245939 1.924345e-08 8.468466e-07 1 225498347 225498404 58 - 2.482 2.398 -0.279
ENSG00000154380 E009 357.3591945 0.0002549666 8.318030e-14 1.052603e-11 1 225500992 225501070 79 - 2.549 2.429 -0.399
ENSG00000154380 E010 1.3639273 0.0150559944 7.192197e-01   1 225501071 225501256 186 - 0.310 0.399 0.531
ENSG00000154380 E011 10.7347023 0.0032983974 3.189570e-06 7.824808e-05 1 225504991 225505053 63 - 0.807 1.322 1.884
ENSG00000154380 E012 321.5731778 0.0001871488 6.936611e-08 2.676048e-06 1 225507951 225508017 67 - 2.493 2.418 -0.251
ENSG00000154380 E013 0.0000000       1 225508389 225508583 195 -      
ENSG00000154380 E014 265.7538505 0.0002423052 2.843970e-05 5.153344e-04 1 225511811 225511859 49 - 2.406 2.349 -0.192
ENSG00000154380 E015 287.6542855 0.0002066950 3.877260e-06 9.254363e-05 1 225512657 225512714 58 - 2.442 2.378 -0.214
ENSG00000154380 E016 326.2282414 0.0002016805 4.330876e-07 1.364025e-05 1 225512871 225513016 146 - 2.497 2.429 -0.226
ENSG00000154380 E017 251.7347767 0.0002571172 2.622027e-04 3.346443e-03 1 225514596 225514900 305 - 2.380 2.333 -0.156
ENSG00000154380 E018 7.3503068 0.3158493955 6.921329e-01 8.304079e-01 1 225514901 225515397 497 - 0.896 0.860 -0.137
ENSG00000154380 E019 162.5559879 0.0002562210 4.366909e-02 1.642892e-01 1 225517196 225517306 111 - 2.182 2.165 -0.056
ENSG00000154380 E020 102.0489554 0.0053082487 6.707969e-01 8.168651e-01 1 225517307 225517990 684 - 1.960 2.018 0.194
ENSG00000154380 E021 8.4517918 0.0810894087 1.150940e-01 3.076255e-01 1 225519044 225519197 154 - 0.837 1.123 1.064
ENSG00000154380 E022 397.0717318 0.0018486338 3.568267e-01 5.931803e-01 1 225519198 225519417 220 - 2.543 2.613 0.235
ENSG00000154380 E023 383.5532765 0.0012665463 1.656632e-01 3.847084e-01 1 225519418 225519565 148 - 2.524 2.605 0.268
ENSG00000154380 E024 0.0000000       1 225524599 225524689 91 -      
ENSG00000154380 E025 324.9879773 0.0003512252 1.475260e-01 3.587809e-01 1 225530554 225530638 85 - 2.475 2.487 0.042
ENSG00000154380 E026 0.6129023 0.0189682693 8.002559e-01   1 225531046 225531057 12 - 0.211 0.176 -0.324
ENSG00000154380 E027 5.5103035 0.0054731551 4.913551e-01 6.948694e-01 1 225535507 225535563 57 - 0.746 0.875 0.505
ENSG00000154380 E028 421.9493547 0.0001641100 2.170546e-03 1.820739e-02 1 225554906 225555083 178 - 2.595 2.581 -0.046
ENSG00000154380 E029 351.0382569 0.0002033692 3.997917e-02 1.546623e-01 1 225567249 225567414 166 - 2.511 2.512 0.005
ENSG00000154380 E030 0.2852693 0.3165989798 6.453661e-01   1 225577853 225577936 84 - 0.149 0.000 -10.175
ENSG00000154380 E031 0.0000000       1 225580167 225580257 91 -      
ENSG00000154380 E032 3.2707439 0.0250046611 5.495853e-01 7.360005e-01 1 225595208 225595325 118 - 0.616 0.544 -0.323
ENSG00000154380 E033 12.3876207 0.0026795084 3.100118e-01 5.504606e-01 1 225600208 225600362 155 - 1.049 1.190 0.506
ENSG00000154380 E034 0.4842470 0.8071215470 6.510789e-01   1 225600363 225600364 2 - 0.212 0.000 -10.798
ENSG00000154380 E035 4.4869026 0.1048040257 4.324329e-02 1.631826e-01 1 225652318 225652433 116 - 0.542 0.939 1.630
ENSG00000154380 E036 217.6205720 0.0008323229 9.439093e-03 5.569754e-02 1 225652686 225653142 457 - 2.268 2.386 0.394