ENSG00000154310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341852 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding protein_coding 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 0.9615630 0.1402220 1.6707639 0.1402220 0.2192697 3.4839487 0.15636667 0.03396667 0.30223333 0.26826667 0.0935361986 0.0002319109 FALSE TRUE
ENST00000436636 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding protein_coding 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 2.1076336 1.8187771 1.3595404 0.5500677 0.6243160 -0.4171874 0.37582917 0.41343333 0.23580000 -0.17763333 0.6987121124 0.0002319109 FALSE TRUE
ENST00000465393 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding protein_coding 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 1.0868751 0.9504309 0.3860508 0.4652389 0.1906031 -1.2779962 0.20280000 0.19306667 0.06570000 -0.12736667 0.2198864261 0.0002319109   FALSE
ENST00000470834 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding protein_coding 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 0.8153014 0.0000000 1.5319687 0.0000000 0.6505314 7.2686297 0.13172917 0.00000000 0.29073333 0.29073333 0.0002319109 0.0002319109 FALSE TRUE
ENST00000475336 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding protein_coding 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 0.2206364 0.5053096 0.3070333 0.2852944 0.3070333 -0.7008050 0.04389167 0.12760000 0.05726667 -0.07033333 0.7294231028 0.0002319109 FALSE TRUE
ENST00000496492 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding retained_intron 5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 0.1879946 0.3936918 0.1175286 0.2479510 0.1175286 -1.6624335 0.03547083 0.09113333 0.01856667 -0.07256667 0.6910875671 0.0002319109 FALSE TRUE
MSTRG.24058.4 ENSG00000154310 HEK293_OSMI2_6hA HEK293_TMG_6hB TNIK protein_coding   5.623921 4.383776 5.548888 1.327125 0.4107838 0.339335 0.1200832 0.3342883 0.0000000 0.2087316 0.0000000 -5.1055451 0.02861250 0.10070000 0.00000000 -0.10070000 0.3002349754 0.0002319109 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000154310 E001 204.7385266 0.5290448953 1.827418e-01 4.075935e-01 3 171058414 171063260 4847 - 2.103 2.486 1.277
ENSG00000154310 E002 21.2331959 0.4048237050 3.812804e-01 6.132749e-01 3 171063261 171063329 69 - 1.250 1.443 0.671
ENSG00000154310 E003 32.5396783 0.5639828430 4.307874e-01 6.517382e-01 3 171063330 171063483 154 - 1.438 1.613 0.597
ENSG00000154310 E004 19.1683080 0.3461012272 3.141178e-01 5.543431e-01 3 171063484 171063550 67 - 1.186 1.420 0.817
ENSG00000154310 E005 10.3883602 0.1523619215 2.495984e-01 4.874485e-01 3 171063551 171063551 1 - 0.918 1.194 1.006
ENSG00000154310 E006 22.6266106 0.3743050441 2.539499e-01 4.923307e-01 3 171063552 171063628 77 - 1.213 1.519 1.063
ENSG00000154310 E007 21.8770482 0.4018172436 2.966355e-01 5.371442e-01 3 171063629 171063682 54 - 1.196 1.505 1.078
ENSG00000154310 E008 35.6147163 0.4917162291 2.044241e-01 4.351346e-01 3 171063683 171063880 198 - 1.360 1.733 1.277
ENSG00000154310 E009 20.7789365 0.3620164845 2.615663e-01 5.006422e-01 3 171063881 171063964 84 - 1.174 1.485 1.087
ENSG00000154310 E010 1.1859435 0.0244421844 8.178945e-01   3 171063965 171064042 78 - 0.323 0.329 0.037
ENSG00000154310 E011 34.4141340 0.0012715571 2.887420e-01 5.294196e-01 3 171066187 171066326 140 - 1.477 1.631 0.525
ENSG00000154310 E012 0.5363366 0.0229078951 7.242165e-02   3 171066374 171066469 96 - 0.000 0.329 13.041
ENSG00000154310 E013 0.0000000       3 171066470 171066486 17 -      
ENSG00000154310 E014 0.4054685 0.3698849369 2.607086e-01   3 171066487 171066575 89 - 0.000 0.252 12.519
ENSG00000154310 E015 42.6845683 0.0009872581 9.569786e-01 9.803551e-01 3 171066576 171066735 160 - 1.596 1.685 0.302
ENSG00000154310 E016 34.7919663 0.0155561568 3.212988e-01 5.608265e-01 3 171068848 171068987 140 - 1.543 1.555 0.044
ENSG00000154310 E017 15.7444928 0.0454596099 3.492751e-01 5.866202e-01 3 171068988 171068997 10 - 1.235 1.194 -0.146
ENSG00000154310 E018 28.7786234 0.0048226344 1.058837e-01 2.921396e-01 3 171071223 171071323 101 - 1.482 1.459 -0.077
ENSG00000154310 E019 0.0000000       3 171071324 171071406 83 -      
ENSG00000154310 E020 32.9506953 0.0011967652 7.779131e-02 2.403703e-01 3 171079518 171079652 135 - 1.534 1.518 -0.054
ENSG00000154310 E021 38.4352723 0.0242363532 4.449066e-01 6.620811e-01 3 171082251 171082394 144 - 1.585 1.597 0.040
ENSG00000154310 E022 0.4764247 0.0214139660 6.344646e-01   3 171082395 171082682 288 - 0.191 0.139 -0.555
ENSG00000154310 E023 44.4822454 0.0082685616 8.917027e-02 2.622510e-01 3 171084155 171084325 171 - 1.662 1.639 -0.077
ENSG00000154310 E024 29.9268279 0.0101443793 4.026502e-01 6.304920e-01 3 171085118 171085229 112 - 1.471 1.499 0.096
ENSG00000154310 E025 33.2455893 0.0584335338 9.445980e-01 9.746432e-01 3 171087342 171087506 165 - 1.486 1.579 0.317
ENSG00000154310 E026 34.6526276 0.0426189885 5.938763e-01 7.662735e-01 3 171093839 171093968 130 - 1.525 1.566 0.141
ENSG00000154310 E027 41.4156212 0.0324803147 5.185942e-01 7.141134e-01 3 171101449 171101633 185 - 1.608 1.634 0.090
ENSG00000154310 E028 0.1723744 0.0887678200 4.435958e-01   3 171101634 171102072 439 - 0.000 0.139 11.457
ENSG00000154310 E029 9.7344786 0.0458011608 2.711918e-01 5.111832e-01 3 171107183 171107206 24 - 1.043 0.975 -0.250
ENSG00000154310 E030 29.1804943 0.0120991584 8.437856e-02 2.535073e-01 3 171108065 171108162 98 - 1.489 1.441 -0.164
ENSG00000154310 E031 32.7541934 0.0011724813 1.375676e-02 7.338277e-02 3 171110714 171110877 164 - 1.548 1.488 -0.206
ENSG00000154310 E032 25.6027165 0.0023527933 4.827434e-04 5.518743e-03 3 171123596 171123702 107 - 1.486 1.328 -0.545
ENSG00000154310 E033 29.4760627 0.0361250859 5.345261e-02 1.877763e-01 3 171125912 171126151 240 - 1.530 1.406 -0.425
ENSG00000154310 E034 16.4702925 0.0524010762 1.506405e-01 3.632085e-01 3 171128714 171128878 165 - 1.278 1.172 -0.374
ENSG00000154310 E035 24.5163181 0.0064032752 3.535656e-01 5.904919e-01 3 171138191 171138379 189 - 1.390 1.412 0.077
ENSG00000154310 E036 0.1614157 0.0333526319 5.422155e-01   3 171139470 171139556 87 - 0.106 0.000 -10.601
ENSG00000154310 E037 18.1282060 0.0023917961 4.602873e-01 6.733203e-01 3 171140399 171140509 111 - 1.265 1.297 0.109
ENSG00000154310 E038 20.7836942 0.0018746084 7.165938e-01 8.459910e-01 3 171157460 171157550 91 - 1.309 1.372 0.220
ENSG00000154310 E039 21.4477763 0.0026255884 7.955662e-01 8.937732e-01 3 171157551 171157664 114 - 1.320 1.392 0.249
ENSG00000154310 E040 21.7238672 0.0021330866 5.713394e-01 7.512829e-01 3 171161270 171161336 67 - 1.337 1.385 0.167
ENSG00000154310 E041 28.5085999 0.0023466970 1.980185e-01 4.271579e-01 3 171167095 171167270 176 - 1.466 1.471 0.017
ENSG00000154310 E042 17.9063780 0.0036518864 7.097904e-01 8.416615e-01 3 171175252 171175330 79 - 1.252 1.312 0.210
ENSG00000154310 E043 14.5917491 0.0024802272 1.366149e-01 3.423194e-01 3 171177326 171177380 55 - 1.217 1.173 -0.155
ENSG00000154310 E044 22.4187640 0.0016396251 7.570619e-02 2.362058e-01 3 171188702 171188832 131 - 1.389 1.351 -0.134
ENSG00000154310 E045 20.8434425 0.0016616533 2.133616e-04 2.823699e-03 3 171190697 171190787 91 - 1.413 1.216 -0.690
ENSG00000154310 E046 24.4708050 0.0024042662 1.140641e-08 5.282439e-07 3 171194525 171194635 111 - 1.520 1.174 -1.205
ENSG00000154310 E047 23.1297864 0.0191831670 1.910685e-03 1.647767e-02 3 171211116 171211241 126 - 1.455 1.237 -0.761
ENSG00000154310 E048 0.0000000       3 171225534 171225711 178 -      
ENSG00000154310 E049 13.7394758 0.0069626975 3.786368e-03 2.794626e-02 3 171228165 171228221 57 - 1.232 1.033 -0.713
ENSG00000154310 E050 6.8712466 0.1134821559 7.908481e-02 2.429975e-01 3 171346934 171347218 285 - 0.637 1.077 1.716
ENSG00000154310 E051 22.3033781 0.0107689008 1.503974e-01 3.628645e-01 3 171369620 171369685 66 - 1.370 1.339 -0.109
ENSG00000154310 E052 31.7116769 0.0017583615 3.006226e-01 5.410986e-01 3 171460007 171460408 402 - 1.431 1.587 0.535