ENSG00000154309

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420335 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding processed_transcript 15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.0800059 0.9691843 0.3327326 0.6713645 0.1743056 -1.51449686 0.07320000 0.11686667 0.02786667 -0.08900000 9.202006e-01 8.426772e-07    
ENST00000435378 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding processed_transcript 15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.1377880 0.3321366 1.0037484 0.1999344 0.1310543 1.56705537 0.07205833 0.04303333 0.08203333 0.03900000 7.068872e-01 8.426772e-07    
ENST00000450784 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding processed_transcript 15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 2.3001135 1.8731410 2.2917238 0.7104446 0.5159062 0.28957374 0.15034167 0.20436667 0.19163333 -0.01273333 1.000000e+00 8.426772e-07    
ENST00000675850 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding protein_coding 15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 0.1684699 0.0000000 0.8908998 0.0000000 0.1925899 6.49329482 0.01339583 0.00000000 0.07426667 0.07426667 8.426772e-07 8.426772e-07 FALSE  
MSTRG.3105.13 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding   15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.6572707 0.3070531 1.1160042 0.1782667 0.3070017 1.82841597 0.10392917 0.03973333 0.09210000 0.05236667 6.697942e-01 8.426772e-07    
MSTRG.3105.14 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding   15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.8334356 0.9162890 1.1271836 0.4953702 1.1271836 0.29593087 0.11710833 0.10443333 0.08826667 -0.01616667 7.285174e-01 8.426772e-07    
MSTRG.3105.15 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding   15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 0.9477052 0.3511409 1.2142574 0.3511409 0.6387839 1.76127307 0.06711667 0.04550000 0.09660000 0.05110000 7.233730e-01 8.426772e-07 FALSE  
MSTRG.3105.3 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding   15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.0695708 0.4095433 1.0896545 0.2955693 0.1955299 1.39015854 0.06678750 0.03986667 0.09016667 0.05030000 6.233147e-01 8.426772e-07    
MSTRG.3105.30 ENSG00000154309 HEK293_OSMI2_6hA HEK293_TMG_6hB DISP1 protein_coding   15.22179 8.886167 12.15787 1.159407 0.3956759 0.4518207 1.0447788 0.4686491 0.4396616 0.1449262 0.1003168 -0.09012859 0.06299167 0.05346667 0.03670000 -0.01676667 8.577651e-01 8.426772e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000154309 E001 0.8148287 0.017124560 0.14075146   1 222815022 222815028 7 + 0.111 0.386 2.295
ENSG00000154309 E002 1.2724724 0.014049367 0.39795976   1 222815029 222815035 7 + 0.272 0.445 1.035
ENSG00000154309 E003 1.4033405 0.013696863 0.25305446 0.49131709 1 222815036 222815036 1 + 0.272 0.497 1.296
ENSG00000154309 E004 1.4033405 0.013696863 0.25305446 0.49131709 1 222815037 222815038 2 + 0.272 0.497 1.296
ENSG00000154309 E005 2.6188361 0.008343398 0.09007933 0.26393731 1 222815039 222815043 5 + 0.390 0.693 1.437
ENSG00000154309 E006 2.6188361 0.008343398 0.09007933 0.26393731 1 222815044 222815046 3 + 0.390 0.693 1.437
ENSG00000154309 E007 2.7802518 0.007801461 0.15821401 0.37408810 1 222815047 222815050 4 + 0.439 0.693 1.173
ENSG00000154309 E008 5.1088110 0.042839349 0.83604848 0.91720293 1 222815051 222815058 8 + 0.774 0.782 0.030
ENSG00000154309 E009 7.6569641 0.008239533 0.73019820 0.85435500 1 222815059 222815063 5 + 0.933 0.931 -0.007
ENSG00000154309 E010 10.1776065 0.033221710 0.43717459 0.65658153 1 222815064 222815068 5 + 1.070 1.014 -0.206
ENSG00000154309 E011 11.2017744 0.026929075 0.25844127 0.49725483 1 222815069 222815069 1 + 1.122 1.029 -0.335
ENSG00000154309 E012 16.2701244 0.042018239 0.36562355 0.60044375 1 222815070 222815077 8 + 1.261 1.197 -0.226
ENSG00000154309 E013 16.2701244 0.042018239 0.36562355 0.60044375 1 222815078 222815078 1 + 1.261 1.197 -0.226
ENSG00000154309 E014 0.9571035 0.439667826 0.55170605   1 222815079 222815086 8 + 0.343 0.226 -0.819
ENSG00000154309 E015 2.5032663 0.060205541 0.75415130 0.86922924 1 222815087 222815109 23 + 0.560 0.541 -0.085
ENSG00000154309 E016 2.5032663 0.060205541 0.75415130 0.86922924 1 222815110 222815110 1 + 0.560 0.541 -0.085
ENSG00000154309 E017 4.2460064 0.072158360 0.97237451 0.98816447 1 222815111 222815128 18 + 0.707 0.746 0.163
ENSG00000154309 E018 8.6906676 0.032536241 0.65463599 0.80648029 1 222815129 222815171 43 + 0.934 1.040 0.395
ENSG00000154309 E019 0.5834523 0.334612762 0.63119028   1 222815359 222815455 97 + 0.112 0.242 1.342
ENSG00000154309 E020 1.5340888 0.096065551 0.89407775 0.94872971 1 222823856 222823883 28 + 0.389 0.390 0.005
ENSG00000154309 E021 17.6063483 0.065659600 0.57413645 0.75312578 1 222823884 222823945 62 + 1.284 1.251 -0.115
ENSG00000154309 E022 0.0000000       1 222824200 222824339 140 +      
ENSG00000154309 E023 0.1308682 0.031605869 0.44818926   1 222824863 222824918 56 + 0.000 0.133 25.426
ENSG00000154309 E024 9.4991876 0.031091139 0.57333699 0.75253361 1 222827428 222827601 174 + 1.037 1.010 -0.100
ENSG00000154309 E025 0.2735028 0.025846366 0.93968818   1 222830929 222831042 114 + 0.111 0.133 0.296
ENSG00000154309 E026 37.1013254 0.059529968 0.96359700 0.98371464 1 222835119 222835215 97 + 1.541 1.615 0.252
ENSG00000154309 E027 2.2437275 0.009252033 0.21220273 0.44433088 1 222836923 222836995 73 + 0.390 0.625 1.146
ENSG00000154309 E028 35.8542527 0.029631800 0.38021627 0.61236371 1 222836996 222837066 71 + 1.491 1.633 0.484
ENSG00000154309 E029 39.4298465 0.014069674 0.86109289 0.93093657 1 222837067 222837218 152 + 1.585 1.622 0.125
ENSG00000154309 E030 24.7686527 0.001964735 0.77314567 0.88055228 1 222837219 222837385 167 + 1.375 1.439 0.223
ENSG00000154309 E031 0.1723744 0.037377059 0.44692865   1 222861945 222862060 116 + 0.000 0.133 25.430
ENSG00000154309 E032 3.5429909 0.007120657 0.51190344 0.70941330 1 222872271 222872428 158 + 0.592 0.724 0.560
ENSG00000154309 E033 0.6847684 0.019042817 0.36398833   1 222872429 222872432 4 + 0.273 0.133 -1.286
ENSG00000154309 E034 0.4161375 0.070735068 0.64915821   1 222885024 222885225 202 + 0.198 0.132 -0.703
ENSG00000154309 E035 2.0632859 0.247342188 0.56275176 0.74523501 1 222889580 222892576 2997 + 0.387 0.587 0.994
ENSG00000154309 E036 2.9892311 0.008653167 0.23389798 0.46964053 1 222899781 222899865 85 + 0.653 0.498 -0.702
ENSG00000154309 E037 0.0000000       1 222928424 222928429 6 +      
ENSG00000154309 E038 1.8997318 0.483740989 0.08935958 0.26259407 1 222928430 222928440 11 + 0.605 0.137 -3.036
ENSG00000154309 E039 3.9758370 0.007491296 0.07425590 0.23327030 1 222928441 222928570 130 + 0.774 0.545 -0.981
ENSG00000154309 E040 17.8780615 0.002107898 0.18639690 0.41231118 1 222942807 222942970 164 + 1.305 1.242 -0.224
ENSG00000154309 E041 34.5990652 0.001475785 0.01431452 0.07557231 1 222942971 222943332 362 + 1.599 1.497 -0.349
ENSG00000154309 E042 0.5778428 0.046092401 0.07319030   1 222943333 222943550 218 + 0.000 0.318 27.025
ENSG00000154309 E043 0.1426347 0.030809101 0.53203982   1 222965427 222965477 51 + 0.111 0.000 -24.868
ENSG00000154309 E044 1.1127220 0.134989815 0.72569934   1 222979623 222979862 240 + 0.275 0.382 0.676
ENSG00000154309 E045 12.6961286 0.011968581 0.28219122 0.52255593 1 222983080 222983109 30 + 1.159 1.095 -0.229
ENSG00000154309 E046 25.7715367 0.043195453 0.10507031 0.29075044 1 222990625 222990748 124 + 1.477 1.347 -0.450
ENSG00000154309 E047 27.3241734 0.033864040 0.03802379 0.14968968 1 222991520 222991647 128 + 1.513 1.354 -0.547
ENSG00000154309 E048 0.6542209 0.019387492 0.92038669   1 222991855 222992012 158 + 0.199 0.234 0.297
ENSG00000154309 E049 25.8427375 0.032598461 0.21511286 0.44770712 1 222992013 222992110 98 + 1.450 1.385 -0.223
ENSG00000154309 E050 1.8502132 0.015615961 0.70752917 0.84026503 1 222992111 222994884 2774 + 0.482 0.445 -0.188
ENSG00000154309 E051 21.2121277 0.003350769 0.40937369 0.63557516 1 222994885 222994982 98 + 1.286 1.392 0.370
ENSG00000154309 E052 223.8418747 1.182914033 0.51911999 0.71443368 1 223002385 223005995 3611 + 2.269 2.431 0.543