ENSG00000154305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340535 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding protein_coding 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 2.4533076 5.53467755 0.373409 1.80797901 0.08208064 -3.854148 0.16467917 0.241633333 0.008333333 -0.23330000 8.397101e-14 8.397101e-14 FALSE TRUE
ENST00000344922 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding protein_coding 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 6.9443747 1.97166298 15.108305 0.60975135 0.27697792 2.931513 0.22071250 0.092766667 0.343000000 0.25023333 4.431293e-05 8.397101e-14 FALSE TRUE
ENST00000354906 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding protein_coding 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 2.3365857 0.03880962 6.015339 0.03880962 0.62020752 6.947733 0.06572917 0.001633333 0.136133333 0.13450000 1.576725e-13 8.397101e-14 FALSE TRUE
ENST00000470521 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding retained_intron 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 1.1659357 0.02565771 3.120808 0.02565771 0.44927591 6.456177 0.03310000 0.002133333 0.069933333 0.06780000 5.608373e-10 8.397101e-14 FALSE TRUE
ENST00000475451 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding processed_transcript 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 0.6510573 1.80723689 0.000000 1.39506889 0.00000000 -7.505603 0.03947917 0.076066667 0.000000000 -0.07606667 2.592112e-01 8.397101e-14 TRUE TRUE
ENST00000476400 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding processed_transcript 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 3.2225228 9.55110014 1.374832 2.37376614 0.81975349 -2.787466 0.18645833 0.437366667 0.029566667 -0.40780000 6.330674e-02 8.397101e-14 FALSE FALSE
ENST00000479370 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding processed_transcript 25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 1.1721766 0.65124764 2.061408 0.26389688 0.56678314 1.647349 0.05021667 0.039600000 0.047800000 0.00820000 8.658700e-01 8.397101e-14   FALSE
MSTRG.3099.10 ENSG00000154305 HEK293_OSMI2_6hA HEK293_TMG_6hB MIA3 protein_coding   25.13515 21.7001 44.22389 5.104897 2.00856 1.026786 4.6664415 0.50864322 10.755999 0.50864322 1.00187043 4.375596 0.13800417 0.021300000 0.242366667 0.22106667 7.566703e-02 8.397101e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000154305 E001 0.8192208 0.1646910732 1.742997e-01   1 222618087 222618087 1 + 0.280 0.000 -11.029
ENSG00000154305 E002 1.5287396 0.0444758448 6.527838e-01 8.052423e-01 1 222618088 222618096 9 + 0.355 0.335 -0.123
ENSG00000154305 E003 1.5287396 0.0444758448 6.527838e-01 8.052423e-01 1 222618097 222618098 2 + 0.355 0.335 -0.123
ENSG00000154305 E004 37.4839234 0.0013162704 1.061876e-10 7.495054e-09 1 222618099 222618243 145 + 1.592 1.219 -1.290
ENSG00000154305 E005 73.7754777 0.0006735431 9.493222e-23 3.793335e-20 1 222621159 222621292 134 + 1.884 1.448 -1.481
ENSG00000154305 E006 2.3496233 0.0094687648 4.211102e-01 6.444901e-01 1 222623307 222623351 45 + 0.500 0.436 -0.323
ENSG00000154305 E007 55.3791255 0.0069550586 4.265138e-13 4.694223e-11 1 222624768 222624809 42 + 1.762 1.323 -1.502
ENSG00000154305 E008 59.5003553 0.0128401178 3.074162e-12 2.910053e-10 1 222624810 222624854 45 + 1.796 1.309 -1.667
ENSG00000154305 E009 333.1428658 0.0290477738 3.626084e-14 4.883367e-12 1 222627575 222628473 899 + 2.541 1.997 -1.820
ENSG00000154305 E010 661.0649717 0.0145655285 2.985457e-20 9.102319e-18 1 222628474 222630306 1833 + 2.827 2.392 -1.450
ENSG00000154305 E011 88.8050198 0.0065015728 1.227177e-10 8.534110e-09 1 222630307 222630389 83 + 1.943 1.660 -0.958
ENSG00000154305 E012 112.1631873 0.0054061482 4.016899e-16 7.098458e-14 1 222632165 222632326 162 + 2.052 1.706 -1.167
ENSG00000154305 E013 87.8049957 0.0018080165 7.692667e-15 1.148981e-12 1 222633104 222633249 146 + 1.941 1.661 -0.943
ENSG00000154305 E014 1.2681187 0.0129414293 3.865425e-02   1 222644303 222644325 23 + 0.388 0.000 -11.655
ENSG00000154305 E015 1.3989868 0.0121240972 1.945921e-01 4.228293e-01 1 222644326 222644327 2 + 0.388 0.198 -1.325
ENSG00000154305 E016 4.8044255 0.0057689128 6.629304e-01 8.117161e-01 1 222644328 222644344 17 + 0.712 0.749 0.152
ENSG00000154305 E017 10.1825775 0.0035110071 3.975217e-01 6.263763e-01 1 222644345 222644393 49 + 0.993 1.009 0.060
ENSG00000154305 E018 28.3387122 0.0013141845 4.970152e-03 3.447056e-02 1 222644394 222644586 193 + 1.431 1.337 -0.325
ENSG00000154305 E019 51.2742866 0.0008155137 7.630137e-07 2.245707e-05 1 222645554 222645557 4 + 1.695 1.522 -0.589
ENSG00000154305 E020 125.7834262 0.0071698524 8.456131e-12 7.375683e-10 1 222645558 222645685 128 + 2.092 1.822 -0.909
ENSG00000154305 E021 5.6305564 0.0053790140 5.246945e-04 5.900615e-03 1 222645686 222646135 450 + 0.842 0.333 -2.369
ENSG00000154305 E022 80.7443352 0.0108387226 1.559619e-13 1.863893e-11 1 222648829 222648850 22 + 1.921 1.486 -1.476
ENSG00000154305 E023 6.2819443 0.1172730910 9.681454e-02 2.761393e-01 1 222649263 222649791 529 + 0.855 0.590 -1.091
ENSG00000154305 E024 132.3400511 0.0120341795 1.618753e-14 2.304288e-12 1 222650292 222650380 89 + 2.130 1.725 -1.360
ENSG00000154305 E025 131.0015778 0.0046521305 2.110739e-25 1.123674e-22 1 222650634 222650711 78 + 2.131 1.671 -1.547
ENSG00000154305 E026 162.2382792 0.0059114517 6.187840e-20 1.821209e-17 1 222650793 222650903 111 + 2.213 1.848 -1.224
ENSG00000154305 E027 142.7262114 0.0061683047 2.075077e-14 2.907556e-12 1 222651977 222652048 72 + 2.148 1.856 -0.981
ENSG00000154305 E028 148.2081586 0.0016587120 4.281516e-19 1.100000e-16 1 222652228 222652332 105 + 2.159 1.911 -0.832
ENSG00000154305 E029 173.7988221 0.0329719617 1.042911e-05 2.175001e-04 1 222653008 222653130 123 + 2.236 1.916 -1.072
ENSG00000154305 E030 159.5023537 0.0568715001 8.754522e-04 8.893989e-03 1 222653228 222653339 112 + 2.196 1.896 -1.008
ENSG00000154305 E031 131.1528468 0.0491396804 7.034855e-04 7.472823e-03 1 222654243 222654298 56 + 2.110 1.831 -0.935
ENSG00000154305 E032 180.2888811 0.0002498233 3.655403e-03 2.722820e-02 1 222654389 222654479 91 + 2.138 2.343 0.686
ENSG00000154305 E033 254.2713235 0.0002157273 1.617526e-28 1.163954e-25 1 222654655 222654793 139 + 2.220 2.597 1.259
ENSG00000154305 E034 1.4550696 0.8838976705 4.317562e-01 6.525470e-01 1 222658642 222658721 80 + 0.281 0.520 1.341
ENSG00000154305 E035 215.7985669 0.0399733138 6.008869e-06 1.349972e-04 1 222658722 222658823 102 + 2.061 2.611 1.835
ENSG00000154305 E036 159.9088986 1.3781893970 2.407446e-01 4.774191e-01 1 222659453 222659513 61 + 1.904 2.503 2.003
ENSG00000154305 E037 112.8752422 1.2666200811 2.423480e-01 4.791856e-01 1 222659622 222659657 36 + 1.769 2.342 1.923
ENSG00000154305 E038 135.5513918 1.3368465540 2.599987e-01 4.990140e-01 1 222659734 222659801 68 + 1.855 2.415 1.875
ENSG00000154305 E039 94.2087911 1.2197783097 2.628634e-01 5.020949e-01 1 222659906 222659938 33 + 1.717 2.242 1.765
ENSG00000154305 E040 121.8165382 1.2967111395 2.473165e-01 4.850841e-01 1 222659939 222660006 68 + 1.804 2.373 1.908
ENSG00000154305 E041 147.7187780 1.3310623192 2.062222e-01 4.372577e-01 1 222660177 222660314 138 + 1.843 2.490 2.166
ENSG00000154305 E042 117.1100596 0.1188069766 2.907601e-03 2.284619e-02 1 222662056 222662082 27 + 1.787 2.356 1.910
ENSG00000154305 E043 91.1493970 0.0658372947 2.771205e-04 3.499772e-03 1 222662083 222662089 7 + 1.684 2.245 1.884
ENSG00000154305 E044 121.1208611 0.0319855679 2.143960e-06 5.549364e-05 1 222662090 222662124 35 + 1.816 2.359 1.820
ENSG00000154305 E045 164.6951635 0.0037436396 2.996539e-23 1.285054e-20 1 222662253 222662332 80 + 1.961 2.485 1.755
ENSG00000154305 E046 12.3433417 0.1909118145 9.559732e-01 9.798918e-01 1 222662333 222662457 125 + 1.036 1.128 0.332
ENSG00000154305 E047 31.0498307 0.1048536843 8.459435e-01 9.226406e-01 1 222662458 222662887 430 + 1.405 1.531 0.431
ENSG00000154305 E048 23.1145150 0.0295472667 3.898513e-01 6.203498e-01 1 222662888 222663031 144 + 1.259 1.463 0.709
ENSG00000154305 E049 47.7254847 0.2173206003 7.575833e-01 8.711603e-01 1 222663032 222663970 939 + 1.557 1.779 0.753
ENSG00000154305 E050 6.1497820 0.1346350260 8.952984e-02 2.629397e-01 1 222663971 222663997 27 + 0.646 1.079 1.682
ENSG00000154305 E051 200.1515966 0.0050446263 2.470988e-16 4.464155e-14 1 222663998 222664148 151 + 2.068 2.545 1.592
ENSG00000154305 E052 6.7852079 0.3366780392 3.708539e-01 6.046189e-01 1 222664149 222664654 506 + 0.868 0.667 -0.809
ENSG00000154305 E053 8.1832380 0.0042396909 9.220721e-01 9.633193e-01 1 222664883 222665308 426 + 0.864 0.985 0.454
ENSG00000154305 E054 624.9229142 0.0100248487 3.455448e-08 1.430982e-06 1 222665309 222668007 2699 + 2.600 2.988 1.292