ENSG00000153982

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284116 ENSG00000153982 HEK293_OSMI2_6hA HEK293_TMG_6hB GDPD1 protein_coding protein_coding 5.402615 0.727248 11.92494 0.1001662 0.659236 4.016898 2.74179473 0.52316560 5.7708474 0.07954304 0.10132444 3.438625 0.62972083 0.75196667 0.4880667 -0.26390000 0.5611392670 0.0003920691 FALSE TRUE
ENST00000578026 ENSG00000153982 HEK293_OSMI2_6hA HEK293_TMG_6hB GDPD1 protein_coding nonsense_mediated_decay 5.402615 0.727248 11.92494 0.1001662 0.659236 4.016898 0.68505774 0.00000000 1.9057893 0.00000000 0.40996558 7.581795 0.08298333 0.00000000 0.1591000 0.15910000 0.0063472505 0.0003920691 FALSE TRUE
ENST00000579020 ENSG00000153982 HEK293_OSMI2_6hA HEK293_TMG_6hB GDPD1 protein_coding nonsense_mediated_decay 5.402615 0.727248 11.92494 0.1001662 0.659236 4.016898 1.07607113 0.00000000 2.7663792 0.00000000 0.49793071 8.117061 0.10753333 0.00000000 0.2309000 0.23090000 0.0003920691 0.0003920691 TRUE TRUE
ENST00000581276 ENSG00000153982 HEK293_OSMI2_6hA HEK293_TMG_6hB GDPD1 protein_coding protein_coding 5.402615 0.727248 11.92494 0.1001662 0.659236 4.016898 0.60201119 0.16296217 1.3605657 0.16296217 0.25771387 2.986243 0.11192917 0.17730000 0.1123333 -0.06496667 0.9117981673 0.0003920691 FALSE TRUE
ENST00000583543 ENSG00000153982 HEK293_OSMI2_6hA HEK293_TMG_6hB GDPD1 protein_coding retained_intron 5.402615 0.727248 11.92494 0.1001662 0.659236 4.016898 0.06252892 0.04112021 0.1213612 0.04112021 0.08482652 1.361573 0.03237500 0.07073333 0.0096000 -0.06113333 0.8196477995 0.0003920691 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153982 E001 1.171792 0.0157516264 0.61836265   17 59220467 59220510 44 + 0.204 0.311 0.806
ENSG00000153982 E002 2.593316 0.0086664623 0.21354216 0.44583137 17 59220511 59220521 11 + 0.361 0.617 1.277
ENSG00000153982 E003 3.040001 0.0077047137 0.32385709 0.56316114 17 59220522 59220529 8 + 0.414 0.617 0.978
ENSG00000153982 E004 7.892468 0.0036771436 0.20281487 0.43311531 17 59220530 59220561 32 + 0.714 0.920 0.809
ENSG00000153982 E005 30.126359 0.0013615282 0.50562310 0.70468880 17 59220562 59220681 120 + 1.251 1.319 0.239
ENSG00000153982 E006 34.038670 0.0010567091 0.88655173 0.94487808 17 59220682 59220751 70 + 1.310 1.297 -0.045
ENSG00000153982 E007 27.634108 0.0024028713 0.94732825 0.97597717 17 59234492 59234534 43 + 1.228 1.222 -0.022
ENSG00000153982 E008 42.019920 0.0014526083 0.64135391 0.79771195 17 59245414 59245549 136 + 1.403 1.361 -0.145
ENSG00000153982 E009 32.455232 0.0011090552 0.86099556 0.93087282 17 59248740 59248785 46 + 1.290 1.274 -0.059
ENSG00000153982 E010 1.102499 0.0191929701 0.01690404   17 59248786 59249228 443 + 0.146 0.617 2.978
ENSG00000153982 E011 44.565691 0.0009348775 0.75927125 0.87209980 17 59257122 59257240 119 + 1.425 1.399 -0.089
ENSG00000153982 E012 33.604324 0.0015775372 0.25165252 0.48967501 17 59257751 59257840 90 + 1.316 1.194 -0.429
ENSG00000153982 E013 15.735384 0.0038695614 0.56859552 0.74923452 17 59267041 59267043 3 + 1.003 0.920 -0.310
ENSG00000153982 E014 44.112809 0.0037354108 0.53190189 0.72339821 17 59267044 59267174 131 + 1.419 1.361 -0.201
ENSG00000153982 E015 36.412324 0.0010297773 0.64686514 0.80139322 17 59270936 59270995 60 + 1.341 1.297 -0.153
ENSG00000153982 E016 30.238980 0.0013549541 0.21258099 0.44477063 17 59272785 59272805 21 + 1.272 1.132 -0.499
ENSG00000153982 E017 37.205700 0.0009792472 0.11618374 0.30947646 17 59272806 59272836 31 + 1.358 1.194 -0.575
ENSG00000153982 E018 2.159325 0.0101479650 0.15254459 0.36598291 17 59272837 59273021 185 + 0.321 0.616 1.515
ENSG00000153982 E019 50.323115 0.0007808904 0.17960059 0.40343258 17 59273651 59273863 213 + 1.478 1.361 -0.405
ENSG00000153982 E020 72.123843 0.0007035071 0.17417004 0.39609609 17 59273864 59275119 1256 + 1.612 1.700 0.300
ENSG00000153982 E021 79.401387 0.0016362342 0.42683105 0.64863026 17 59275120 59275838 719 + 1.658 1.709 0.175
ENSG00000153982 E022 16.182598 0.0034846102 0.01988283 0.09545591 17 59275839 59275970 132 + 0.971 1.249 1.002