ENSG00000153956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356860 ENSG00000153956 HEK293_OSMI2_6hA HEK293_TMG_6hB CACNA2D1 protein_coding protein_coding 4.201043 1.380723 7.703304 0.3379219 0.9712512 2.471514 1.6459312 0.53222871 2.5567690 0.12526024 0.1430647 2.2429800 0.3703958 0.39223333 0.33906667 -0.05316667 8.306434e-01 1.429564e-08 FALSE TRUE
ENST00000464354 ENSG00000153956 HEK293_OSMI2_6hA HEK293_TMG_6hB CACNA2D1 protein_coding processed_transcript 4.201043 1.380723 7.703304 0.3379219 0.9712512 2.471514 0.1093672 0.00000000 0.5209654 0.00000000 0.5209654 5.7305461 0.0136625 0.00000000 0.06220000 0.06220000 1.000000e+00 1.429564e-08 FALSE FALSE
ENST00000475237 ENSG00000153956 HEK293_OSMI2_6hA HEK293_TMG_6hB CACNA2D1 protein_coding retained_intron 4.201043 1.380723 7.703304 0.3379219 0.9712512 2.471514 0.1625966 0.00000000 1.3007729 0.00000000 0.8756510 7.0342740 0.0205500 0.00000000 0.16440000 0.16440000 5.844474e-01 1.429564e-08 FALSE TRUE
MSTRG.30140.15 ENSG00000153956 HEK293_OSMI2_6hA HEK293_TMG_6hB CACNA2D1 protein_coding   4.201043 1.380723 7.703304 0.3379219 0.9712512 2.471514 0.8806804 0.78428342 0.7271232 0.21038145 0.1349412 -0.1077481 0.3624917 0.56536667 0.09443333 -0.47093333 1.429564e-08 1.429564e-08 FALSE TRUE
MSTRG.30140.2 ENSG00000153956 HEK293_OSMI2_6hA HEK293_TMG_6hB CACNA2D1 protein_coding   4.201043 1.380723 7.703304 0.3379219 0.9712512 2.471514 0.8752121 0.05172655 1.9760771 0.04149151 0.1076123 5.0078866 0.1383542 0.03536667 0.26796667 0.23260000 1.798133e-02 1.429564e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153956 E001 48.3858084 0.826142192 1.292276e-01 3.305426e-01 7 81946444 81947435 992 - 1.385 1.946 1.907
ENSG00000153956 E002 95.9158097 1.354840925 3.085264e-01 5.490873e-01 7 81947436 81949778 2343 - 1.709 2.152 1.490
ENSG00000153956 E003 20.8850958 0.699861506 4.353527e-01 6.552476e-01 7 81949779 81950101 323 - 1.109 1.389 0.988
ENSG00000153956 E004 31.4758559 0.818988638 5.564602e-01 7.408142e-01 7 81950102 81950508 407 - 1.302 1.428 0.440
ENSG00000153956 E005 13.8977797 0.003004765 6.784275e-01 8.217387e-01 7 81959275 81959357 83 - 0.989 1.049 0.218
ENSG00000153956 E006 19.5916563 0.033541854 5.399689e-01 7.289724e-01 7 81959720 81959829 110 - 1.120 1.168 0.172
ENSG00000153956 E007 23.3957494 0.062915145 2.943157e-01 5.349112e-01 7 81961894 81962023 130 - 1.199 1.165 -0.123
ENSG00000153956 E008 15.1340134 0.002685058 4.103626e-02 1.574003e-01 7 81962440 81962495 56 - 1.041 0.874 -0.627
ENSG00000153956 E009 11.4236327 0.034815244 2.652647e-01 5.046101e-01 7 81964056 81964108 53 - 0.925 0.868 -0.218
ENSG00000153956 E010 0.1614157 0.034281469 9.372311e-01   7 81964109 81964206 98 - 0.046 0.000 -7.208
ENSG00000153956 E011 16.8216946 0.081871068 2.034860e-01 4.339203e-01 7 81964207 81964359 153 - 1.075 0.996 -0.288
ENSG00000153956 E012 14.3296909 0.042495153 3.951377e-01 6.244797e-01 7 81965594 81965665 72 - 1.002 1.004 0.008
ENSG00000153956 E013 0.1779838 0.068555401 9.399362e-01   7 81967165 81967168 4 - 0.046 0.000 -7.211
ENSG00000153956 E014 11.5402960 0.025672268 2.787812e-01 5.188664e-01 7 81967169 81967207 39 - 0.925 0.872 -0.203
ENSG00000153956 E015 14.1535609 0.016277095 4.728158e-01 6.820267e-01 7 81967596 81967663 68 - 0.994 1.011 0.060
ENSG00000153956 E016 13.8368866 0.024291985 5.698618e-01 7.501938e-01 7 81968887 81968973 87 - 0.984 1.011 0.102
ENSG00000153956 E017 18.3222073 0.003337100 1.397800e-01 3.471362e-01 7 81969881 81969984 104 - 1.110 1.048 -0.226
ENSG00000153956 E018 18.5961214 0.001896964 2.146955e-01 4.471729e-01 7 81970675 81970737 63 - 1.111 1.083 -0.101
ENSG00000153956 E019 0.3206185 0.025452354 1.000000e+00   7 81970738 81971089 352 - 0.088 0.000 -8.207
ENSG00000153956 E020 18.4696367 0.046393202 1.743882e-01 3.963708e-01 7 81971777 81971864 88 - 1.109 1.010 -0.361
ENSG00000153956 E021 20.9015596 0.036320312 1.615183e-03 1.443089e-02 7 81974455 81974552 98 - 1.178 0.753 -1.595
ENSG00000153956 E022 14.5315882 0.002809509 5.934721e-02 2.013369e-01 7 81982567 81982627 61 - 1.023 0.874 -0.560
ENSG00000153956 E023 0.3503582 0.097400004 1.901814e-01   7 81983314 81983334 21 - 0.046 0.285 3.041
ENSG00000153956 E024 15.7348553 0.002708166 6.537835e-02 2.147575e-01 7 81984635 81984711 77 - 1.055 0.924 -0.482
ENSG00000153956 E025 15.5756997 0.022169535 6.159487e-02 2.063785e-01 7 81991185 81991246 62 - 1.047 0.874 -0.649
ENSG00000153956 E026 17.1142372 0.002000601 3.621513e-01 5.974801e-01 7 81994868 81994939 72 - 1.075 1.083 0.027
ENSG00000153956 E027 16.2606838 0.005382737 1.034236e-01 2.879344e-01 7 81997179 81997235 57 - 1.070 0.969 -0.370
ENSG00000153956 E028 2.8924475 0.030971653 8.110723e-01 9.029316e-01 7 81997236 81997250 15 - 0.445 0.577 0.634
ENSG00000153956 E029 1.6123198 0.021153013 7.241945e-01 8.506590e-01 7 82001659 82001715 57 - 0.304 0.284 -0.133
ENSG00000153956 E030 0.0000000       7 82005331 82005422 92 -      
ENSG00000153956 E031 14.2955139 0.002252776 1.356063e-01 3.407271e-01 7 82005423 82005446 24 - 1.014 0.925 -0.332
ENSG00000153956 E032 18.1854711 0.001933528 4.329650e-02 1.633289e-01 7 82005447 82005497 51 - 1.111 0.970 -0.515
ENSG00000153956 E033 24.6916668 0.001769114 1.519202e-02 7.881574e-02 7 82005765 82005839 75 - 1.237 1.083 -0.551
ENSG00000153956 E034 0.0000000       7 82007662 82007678 17 -      
ENSG00000153956 E035 24.1455862 0.002171491 5.386387e-04 6.024714e-03 7 82007679 82007756 78 - 1.235 0.925 -1.128
ENSG00000153956 E036 0.0000000       7 82012043 82012153 111 -      
ENSG00000153956 E037 22.1993901 0.002625274 7.192063e-04 7.606178e-03 7 82012154 82012243 90 - 1.200 0.874 -1.194
ENSG00000153956 E038 0.0000000       7 82012244 82012251 8 -      
ENSG00000153956 E039 16.9619763 0.069800606 2.873323e-01 5.281085e-01 7 82013461 82013510 50 - 1.073 0.977 -0.352
ENSG00000153956 E040 19.5038231 0.023378834 3.213000e-02 1.336077e-01 7 82014401 82014479 79 - 1.138 0.927 -0.772
ENSG00000153956 E041 16.3439833 0.004492513 5.955980e-02 2.017845e-01 7 82032797 82032901 105 - 1.063 0.925 -0.512
ENSG00000153956 E042 0.0000000       7 82033019 82033072 54 -      
ENSG00000153956 E043 20.4266402 0.055220172 5.276126e-01 7.203386e-01 7 82038077 82038235 159 - 1.137 1.148 0.040
ENSG00000153956 E044 0.6129023 0.019209077 5.386676e-01   7 82050336 82050628 293 - 0.126 0.284 1.455
ENSG00000153956 E045 0.1308682 0.032649190 5.689636e-02   7 82050935 82051112 178 - 0.000 0.284 13.252
ENSG00000153956 E046 20.1232751 0.051524959 2.647911e-01 5.040930e-01 7 82060428 82060527 100 - 1.139 1.082 -0.206
ENSG00000153956 E047 12.4346409 0.029729227 2.027045e-01 4.329410e-01 7 82064304 82064354 51 - 0.955 0.871 -0.315
ENSG00000153956 E048 16.8235851 0.002563442 5.556459e-03 3.750306e-02 7 82066455 82066524 70 - 1.092 0.816 -1.032
ENSG00000153956 E049 20.2649384 0.004316580 6.067529e-03 4.006331e-02 7 82084769 82084900 132 - 1.161 0.924 -0.867
ENSG00000153956 E050 19.3027230 0.010529943 1.674927e-03 1.484501e-02 7 82117044 82117173 130 - 1.148 0.815 -1.238
ENSG00000153956 E051 11.1989769 0.003357398 6.805700e-02 2.207174e-01 7 82136635 82136676 42 - 0.925 0.750 -0.682
ENSG00000153956 E052 13.6250101 0.006833326 5.486627e-01 7.354203e-01 7 82170550 82170609 60 - 0.975 1.011 0.133
ENSG00000153956 E053 9.8059693 0.003875990 1.238102e-10 8.603037e-09 7 82299906 82300151 246 - 0.651 1.459 2.996
ENSG00000153956 E054 23.0427559 0.002484525 6.053238e-04 6.624857e-03 7 82335135 82335251 117 - 1.118 1.536 1.457
ENSG00000153956 E055 0.0000000       7 82343054 82343236 183 -      
ENSG00000153956 E056 19.5277308 0.004414014 4.174890e-05 7.135591e-04 7 82349568 82349649 82 - 1.028 1.524 1.747
ENSG00000153956 E057 18.1332045 0.010808935 3.230693e-05 5.750404e-04 7 82443365 82443807 443 - 0.993 1.524 1.874