ENSG00000153944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284073 ENSG00000153944 HEK293_OSMI2_6hA HEK293_TMG_6hB MSI2 protein_coding protein_coding 22.09961 14.91152 24.5723 2.512562 0.5641721 0.7202256 2.629661 1.6215423 2.956276 0.4291161 0.48007253 0.8624164 0.10822083 0.1047333 0.12130000 0.016566667 9.365484e-01 3.19488e-10 FALSE TRUE
ENST00000581523 ENSG00000153944 HEK293_OSMI2_6hA HEK293_TMG_6hB MSI2 protein_coding processed_transcript 22.09961 14.91152 24.5723 2.512562 0.5641721 0.7202256 5.659207 7.0915885 2.743838 1.7641634 0.07762041 -1.3666980 0.30661667 0.4612333 0.11190000 -0.349333333 3.194880e-10 3.19488e-10 FALSE FALSE
ENST00000582453 ENSG00000153944 HEK293_OSMI2_6hA HEK293_TMG_6hB MSI2 protein_coding processed_transcript 22.09961 14.91152 24.5723 2.512562 0.5641721 0.7202256 2.541526 0.8135791 1.739662 0.4851060 1.73966242 1.0870975 0.09405417 0.0663000 0.07326667 0.006966667 7.311514e-01 3.19488e-10 FALSE FALSE
MSTRG.14732.14 ENSG00000153944 HEK293_OSMI2_6hA HEK293_TMG_6hB MSI2 protein_coding   22.09961 14.91152 24.5723 2.512562 0.5641721 0.7202256 1.801146 0.0000000 4.186790 0.0000000 2.10988965 8.7131426 0.06604167 0.0000000 0.16736667 0.167366667 3.274251e-01 3.19488e-10 FALSE TRUE
MSTRG.14732.6 ENSG00000153944 HEK293_OSMI2_6hA HEK293_TMG_6hB MSI2 protein_coding   22.09961 14.91152 24.5723 2.512562 0.5641721 0.7202256 6.596779 3.1688095 11.211074 0.5711961 0.98762908 1.8196523 0.27803333 0.2323333 0.45486667 0.222533333 2.289526e-01 3.19488e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153944 E001 0.7249894 0.0483043484 7.848685e-01   17 57255851 57255981 131 + 0.227 0.280 0.398
ENSG00000153944 E002 0.1308682 0.0326491905 2.476335e-01   17 57256523 57256542 20 + 0.000 0.162 12.808
ENSG00000153944 E003 1.4386897 0.0121989077 4.721697e-02 1.730705e-01 17 57256543 57256735 193 + 0.227 0.571 1.989
ENSG00000153944 E004 2.3050262 0.1567104377 8.170567e-01 9.064429e-01 17 57256736 57256739 4 + 0.489 0.515 0.122
ENSG00000153944 E005 2.6386286 0.1187304266 4.598968e-01 6.730675e-01 17 57256740 57256740 1 + 0.489 0.621 0.613
ENSG00000153944 E006 2.9889868 0.1737005717 4.090212e-01 6.352597e-01 17 57256741 57256742 2 + 0.522 0.667 0.647
ENSG00000153944 E007 18.9707844 0.0019895889 4.489027e-01 6.649078e-01 17 57256743 57256758 16 + 1.259 1.322 0.222
ENSG00000153944 E008 30.1618245 0.0011151556 9.565614e-02 2.741812e-01 17 57256759 57256773 15 + 1.429 1.540 0.380
ENSG00000153944 E009 35.1799749 0.0010395305 5.133246e-02 1.829220e-01 17 57256774 57256781 8 + 1.488 1.608 0.411
ENSG00000153944 E010 42.7149544 0.0010651834 3.777372e-02 1.490196e-01 17 57256782 57256804 23 + 1.570 1.688 0.401
ENSG00000153944 E011 0.4458772 0.0217681645 2.479850e-01   17 57257013 57257017 5 + 0.089 0.281 1.990
ENSG00000153944 E012 0.6238610 0.0193874923 5.050655e-01   17 57257018 57257041 24 + 0.164 0.281 0.989
ENSG00000153944 E013 1.4169600 0.0136968632 9.832826e-01 9.934380e-01 17 57257042 57257051 10 + 0.376 0.373 -0.013
ENSG00000153944 E014 2.3752312 0.0087825838 9.798702e-01 9.917426e-01 17 57257052 57257097 46 + 0.517 0.515 -0.011
ENSG00000153944 E015 55.7027696 0.0008776858 4.018997e-02 1.551714e-01 17 57257098 57257123 26 + 1.689 1.792 0.349
ENSG00000153944 E016 55.0505192 0.0019402205 1.037730e-01 2.885050e-01 17 57257124 57257138 15 + 1.689 1.776 0.293
ENSG00000153944 E017 46.7368113 0.0011612084 2.522639e-01 4.903421e-01 17 57257466 57257469 4 + 1.628 1.692 0.218
ENSG00000153944 E018 94.5779447 0.0005548092 5.873037e-02 1.999262e-01 17 57257470 57257547 78 + 1.927 2.001 0.248
ENSG00000153944 E019 111.3379187 0.0004874299 2.391789e-02 1.088385e-01 17 57258270 57258354 85 + 1.996 2.077 0.272
ENSG00000153944 E020 0.0000000       17 57259977 57260054 78 +      
ENSG00000153944 E021 0.0000000       17 57262115 57262150 36 +      
ENSG00000153944 E022 105.0527510 0.0005584333 1.303421e-01 3.323486e-01 17 57262151 57262192 42 + 1.981 2.038 0.191
ENSG00000153944 E023 0.5339515 0.8141441926 5.845612e-01   17 57262193 57262433 241 + 0.236 0.000 -12.810
ENSG00000153944 E024 0.1723744 0.0377321803 2.461383e-01   17 57263488 57263569 82 + 0.000 0.163 12.765
ENSG00000153944 E025 0.8094069 0.2273834551 7.416330e-02   17 57263570 57268550 4981 + 0.090 0.451 2.991
ENSG00000153944 E026 25.5820771 0.0191054938 6.704156e-14 8.631689e-12 17 57274268 57274489 222 + 0.999 1.732 2.562
ENSG00000153944 E027 0.0000000       17 57285844 57286012 169 +      
ENSG00000153944 E028 0.0000000       17 57294685 57294789 105 +      
ENSG00000153944 E029 0.0000000       17 57310131 57310326 196 +      
ENSG00000153944 E030 1.0183708 0.0153787590 4.148011e-01   17 57364922 57365021 100 + 0.227 0.374 0.992
ENSG00000153944 E031 0.1779838 0.0351555706 1.000000e+00   17 57370949 57370991 43 + 0.090 0.000 -12.269
ENSG00000153944 E032 97.9955835 0.0018378743 5.443201e-06 1.241113e-04 17 57401379 57401471 93 + 2.030 1.831 -0.669
ENSG00000153944 E033 0.0000000       17 57406812 57407039 228 +      
ENSG00000153944 E034 0.0000000       17 57432586 57432614 29 +      
ENSG00000153944 E035 0.0000000       17 57440690 57440739 50 +      
ENSG00000153944 E036 0.0000000       17 57444487 57444752 266 +      
ENSG00000153944 E037 0.0000000       17 57487061 57487289 229 +      
ENSG00000153944 E038 0.1723744 0.0377321803 2.461383e-01   17 57524309 57524378 70 + 0.000 0.163 12.765
ENSG00000153944 E039 67.3226185 0.0023688476 1.877368e-04 2.537771e-03 17 57529676 57529724 49 + 1.870 1.676 -0.657
ENSG00000153944 E040 0.0000000       17 57556990 57557131 142 +      
ENSG00000153944 E041 1.0482981 0.0821992381 4.271184e-01   17 57565923 57565995 73 + 0.228 0.376 1.000
ENSG00000153944 E042 56.1592217 0.0008141510 1.045228e-03 1.025500e-02 17 57596868 57596902 35 + 1.787 1.618 -0.572
ENSG00000153944 E043 58.8328798 0.0008075126 2.403930e-05 4.468505e-04 17 57596903 57596950 48 + 1.819 1.603 -0.733
ENSG00000153944 E044 80.6059652 0.0059004495 1.672378e-02 8.444833e-02 17 57615970 57616084 115 + 1.933 1.804 -0.434
ENSG00000153944 E045 0.0000000       17 57616085 57616631 547 +      
ENSG00000153944 E046 2.5934655 0.0090560517 5.005813e-03 3.465844e-02 17 57625572 57626914 1343 + 0.331 0.778 2.128
ENSG00000153944 E047 0.4514866 0.0217681645 1.000000e+00   17 57626915 57627228 314 + 0.164 0.163 -0.012
ENSG00000153944 E048 59.7524730 0.0140743306 1.069247e-01 2.938850e-01 17 57627229 57627303 75 + 1.801 1.683 -0.401
ENSG00000153944 E049 13.8752193 0.0969933780 5.404330e-03 3.671265e-02 17 57627304 57631790 4487 + 0.913 1.408 1.774
ENSG00000153944 E050 19.7005855 0.0020337868 3.395220e-06 8.261734e-05 17 57631791 57632401 611 + 1.126 1.492 1.281
ENSG00000153944 E051 17.9644004 0.0183936642 8.080923e-05 1.252237e-03 17 57632402 57633183 782 + 1.085 1.486 1.410
ENSG00000153944 E052 0.0000000       17 57650650 57650673 24 +      
ENSG00000153944 E053 52.1178782 0.0064420795 3.233135e-02 1.341915e-01 17 57652099 57652161 63 + 1.748 1.611 -0.465
ENSG00000153944 E054 0.0000000       17 57655695 57655744 50 +      
ENSG00000153944 E055 0.2027342 0.0353945174 2.461563e-01   17 57671474 57671574 101 + 0.000 0.163 12.788
ENSG00000153944 E056 16.4442720 0.0024140575 2.825870e-01 5.229980e-01 17 57674918 57674971 54 + 1.248 1.152 -0.341
ENSG00000153944 E057 64.3594142 0.0006050104 3.513319e-02 1.419360e-01 17 57674972 57675126 155 + 1.824 1.727 -0.330
ENSG00000153944 E058 65.8391299 0.0040635511 2.130958e-02 1.003510e-01 17 57676987 57677059 73 + 1.845 1.721 -0.419
ENSG00000153944 E059 66.9561372 0.0016324177 1.895532e-04 2.559066e-03 17 57679549 57679606 58 + 1.866 1.679 -0.630
ENSG00000153944 E060 1259.9106618 0.0003023117 8.049706e-01 8.991812e-01 17 57679607 57684689 5083 + 3.075 3.080 0.014
ENSG00000153944 E061 0.6294705 0.0272265208 7.195707e-01   17 57700368 57700433 66 + 0.227 0.163 -0.599