ENSG00000153898

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370608 ENSG00000153898 HEK293_OSMI2_6hA HEK293_TMG_6hB MCOLN2 protein_coding protein_coding 8.472111 4.057247 10.8646 0.3849736 0.6127325 1.418838 4.9093564 1.5604083 6.8818755 0.11201709 0.3133421 2.1337569 0.54922083 0.38693333 0.64090000 0.25396667 0.109695010 0.008276351 FALSE TRUE
ENST00000530971 ENSG00000153898 HEK293_OSMI2_6hA HEK293_TMG_6hB MCOLN2 protein_coding retained_intron 8.472111 4.057247 10.8646 0.3849736 0.6127325 1.418838 1.9150234 1.5824797 2.2657314 0.29026085 0.6558062 0.5150553 0.25018333 0.38646667 0.20293333 -0.18353333 0.310521701 0.008276351   FALSE
ENST00000531325 ENSG00000153898 HEK293_OSMI2_6hA HEK293_TMG_6hB MCOLN2 protein_coding processed_transcript 8.472111 4.057247 10.8646 0.3849736 0.6127325 1.418838 0.5268778 0.1007453 1.2075163 0.05071991 0.2870453 3.4586231 0.04595417 0.02266667 0.10980000 0.08713333 0.081494147 0.008276351 FALSE TRUE
ENST00000531874 ENSG00000153898 HEK293_OSMI2_6hA HEK293_TMG_6hB MCOLN2 protein_coding processed_transcript 8.472111 4.057247 10.8646 0.3849736 0.6127325 1.418838 0.8497922 0.8034200 0.3478557 0.16938262 0.1236640 -1.1846227 0.12815833 0.20160000 0.03173333 -0.16986667 0.008276351 0.008276351   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153898 E001 27.998132 0.615943157 2.009030e-01 0.4308529099 1 84925583 84925907 325 - 1.247 1.669 1.454
ENSG00000153898 E002 67.826565 0.925941277 2.574609e-01 0.4961957653 1 84925908 84926425 518 - 1.625 2.033 1.377
ENSG00000153898 E003 40.537545 0.772715023 3.165279e-01 0.5565343493 1 84926426 84926684 259 - 1.436 1.766 1.125
ENSG00000153898 E004 14.113489 0.406405069 2.174211e-01 0.4502945880 1 84926685 84926721 37 - 0.991 1.356 1.302
ENSG00000153898 E005 27.080959 0.008892097 4.012266e-02 0.1550073997 1 84929558 84929679 122 - 1.291 1.573 0.975
ENSG00000153898 E006 12.386758 0.103441352 9.922170e-03 0.0578187792 1 84929680 84929844 165 - 0.831 1.437 2.189
ENSG00000153898 E007 39.937601 0.025966880 9.631680e-01 0.9835320843 1 84931362 84931568 207 - 1.486 1.629 0.487
ENSG00000153898 E008 6.767712 0.107083747 9.467668e-01 0.9756965022 1 84937460 84937593 134 - 0.776 0.913 0.529
ENSG00000153898 E009 32.543101 0.020509938 1.554011e-01 0.3700494004 1 84937755 84937877 123 - 1.434 1.422 -0.041
ENSG00000153898 E010 28.884822 0.024378750 8.926522e-03 0.0534936775 1 84937981 84938082 102 - 1.410 1.241 -0.590
ENSG00000153898 E011 37.644653 0.019568255 1.614815e-02 0.0823175575 1 84939553 84939702 150 - 1.512 1.403 -0.375
ENSG00000153898 E012 28.046473 0.019763564 6.576807e-02 0.2156514351 1 84940879 84940991 113 - 1.381 1.314 -0.233
ENSG00000153898 E013 18.503443 0.002470118 2.298598e-01 0.4650070990 1 84947033 84947079 47 - 1.199 1.204 0.017
ENSG00000153898 E014 20.659820 0.016852168 2.566209e-01 0.4954088608 1 84947080 84947132 53 - 1.247 1.239 -0.027
ENSG00000153898 E015 29.351131 0.001218188 1.693743e-03 0.0149771675 1 84952243 84952339 97 - 1.415 1.285 -0.454
ENSG00000153898 E016 33.527577 0.001416575 2.612910e-05 0.0004787788 1 84952446 84952530 85 - 1.480 1.270 -0.728
ENSG00000153898 E017 38.599713 0.009659178 1.219320e-05 0.0002489703 1 84956431 84956584 154 - 1.547 1.284 -0.907
ENSG00000153898 E018 30.505812 0.001274490 1.230453e-03 0.0116535160 1 84958529 84958702 174 - 1.434 1.299 -0.466
ENSG00000153898 E019 34.361425 0.042883493 1.077971e-02 0.0614516100 1 84965549 84965708 160 - 1.488 1.315 -0.597
ENSG00000153898 E020 5.011955 0.097501173 5.470889e-05 0.0008999252 1 84971936 84972034 99 - 0.359 1.190 3.496
ENSG00000153898 E021 37.819575 0.046383459 8.843563e-01 0.9436285084 1 84996796 84997007 212 - 1.462 1.617 0.531
ENSG00000153898 E022 15.992478 0.038212687 1.226304e-01 0.3199388781 1 84997008 84997113 106 - 1.058 1.381 1.144