ENSG00000153786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313732 ENSG00000153786 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC7 protein_coding protein_coding 33.57847 37.89272 33.26375 2.017336 1.852744 -0.1879167 26.853424 32.7461661 22.501928 1.7282024 0.8632590 -0.5410769 0.79835000 0.864433333 0.67826667 -0.1861667 7.510073e-05 7.510073e-05 FALSE TRUE
ENST00000564526 ENSG00000153786 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC7 protein_coding retained_intron 33.57847 37.89272 33.26375 2.017336 1.852744 -0.1879167 1.452842 0.2398885 5.319935 0.2398885 1.2331320 4.4147616 0.04318750 0.005933333 0.15710000 0.1511667 1.892445e-02 7.510073e-05 FALSE FALSE
ENST00000566909 ENSG00000153786 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC7 protein_coding protein_coding 33.57847 37.89272 33.26375 2.017336 1.852744 -0.1879167 1.900813 2.4410996 1.914870 0.5079360 0.4189296 -0.3486684 0.05424583 0.063366667 0.05926667 -0.0041000 9.658040e-01 7.510073e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153786 E001 2.3490762 0.4881978611 6.434274e-01 7.991357e-01 16 84974175 84974459 285 - 0.342 0.583 1.241
ENSG00000153786 E002 15.5883415 0.0355757905 1.309914e-01 3.333610e-01 16 84974460 84974511 52 - 1.072 1.270 0.705
ENSG00000153786 E003 526.8057446 0.0008329617 5.268831e-04 5.922875e-03 16 84974512 84974878 367 - 2.659 2.737 0.260
ENSG00000153786 E004 701.4135855 0.0002877676 5.992250e-09 2.941954e-07 16 84974879 84975412 534 - 2.773 2.865 0.307
ENSG00000153786 E005 764.2419364 0.0011741571 1.944227e-03 1.669318e-02 16 84975413 84976103 691 - 2.827 2.895 0.226
ENSG00000153786 E006 245.7745475 0.0003223418 6.869584e-01 8.271697e-01 16 84976104 84976212 109 - 2.368 2.384 0.050
ENSG00000153786 E007 156.1683838 0.0002932875 8.306708e-01 9.141615e-01 16 84976213 84976245 33 - 2.180 2.180 -0.003
ENSG00000153786 E008 432.8700856 0.0001641580 4.494441e-04 5.218155e-03 16 84976246 84976495 250 - 2.655 2.599 -0.185
ENSG00000153786 E009 218.5076796 0.0003147680 1.412657e-07 5.065490e-06 16 84976496 84976519 24 - 2.396 2.271 -0.418
ENSG00000153786 E010 213.8490981 0.0011131311 2.034212e-06 5.297592e-05 16 84977095 84977107 13 - 2.390 2.262 -0.430
ENSG00000153786 E011 320.5602933 0.0003394732 8.897190e-05 1.355110e-03 16 84977108 84977225 118 - 2.536 2.459 -0.256
ENSG00000153786 E012 0.9630002 0.1781933048 3.412952e-01   16 84977226 84977281 56 - 0.146 0.362 1.700
ENSG00000153786 E013 231.6453319 0.0025743481 3.101636e-01 5.506496e-01 16 84977924 84978005 82 - 2.367 2.340 -0.090
ENSG00000153786 E014 1.2247365 0.0483597763 1.197903e-01   16 84978006 84978126 121 - 0.147 0.448 2.166
ENSG00000153786 E015 186.9620403 0.0020513077 8.817684e-01 9.422836e-01 16 84979189 84979285 97 - 2.252 2.263 0.037
ENSG00000153786 E016 254.6671201 0.0001896398 1.386593e-01 3.454795e-01 16 84981870 84981994 125 - 2.408 2.379 -0.095
ENSG00000153786 E017 10.9876464 0.0423341607 1.300927e-01 3.319769e-01 16 84981995 84982117 123 - 0.896 1.142 0.904
ENSG00000153786 E018 30.2621059 0.0012517753 6.904484e-04 7.361041e-03 16 84988763 84988873 111 - 1.594 1.381 -0.730
ENSG00000153786 E019 183.5521054 0.0003713175 3.679151e-01 6.023519e-01 16 84990304 84990332 29 - 2.262 2.243 -0.063
ENSG00000153786 E020 352.3255909 0.0004271311 5.311913e-02 1.870575e-01 16 84990333 84990635 303 - 2.552 2.519 -0.111
ENSG00000153786 E021 89.5495212 0.0005682604 5.544747e-01 7.394520e-01 16 84995922 84996007 86 - 1.920 1.949 0.097
ENSG00000153786 E022 0.3337900 0.0273456545 7.398063e-01   16 85004917 85005010 94 - 0.147 0.100 -0.637
ENSG00000153786 E023 48.9744899 0.0070357306 1.342458e-01 3.385059e-01 16 85011286 85011535 250 - 1.607 1.718 0.376