ENSG00000153339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283351 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding protein_coding 17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 2.1802439 0.71228097 3.2802719 0.15169322 0.36515354 2.187575 0.14427500 0.143933333 0.101200000 -0.04273333 0.513170925 0.001065589 FALSE TRUE
ENST00000580104 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding nonsense_mediated_decay 17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 2.3653132 1.16225122 4.3741589 0.31603966 0.51214427 1.903018 0.16430417 0.226033333 0.135500000 -0.09053333 0.383981890 0.001065589 TRUE TRUE
ENST00000581057 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding protein_coding 17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 0.2651621 0.98388987 0.2048472 0.63081337 0.01454783 -2.209775 0.03574167 0.161066667 0.006366667 -0.15470000 0.319630535 0.001065589   FALSE
ENST00000582509 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding processed_transcript 17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 2.9059476 0.63986901 3.7256346 0.31994891 0.46933793 2.523133 0.23775000 0.160866667 0.114866667 -0.04600000 0.999557869 0.001065589   FALSE
ENST00000582539 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding protein_coding 17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 5.6918074 1.25356570 12.7656256 0.23272626 0.89706091 3.337821 0.25431250 0.253000000 0.395100000 0.14210000 0.026206373 0.001065589 FALSE TRUE
MSTRG.15652.5 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding   17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 1.1068482 0.04077338 2.6375966 0.04077338 0.80105671 5.704467 0.03926250 0.006133333 0.080533333 0.07440000 0.023452817 0.001065589 FALSE TRUE
MSTRG.15652.7 ENSG00000153339 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC8 protein_coding   17.52133 4.984937 32.23172 0.9631254 1.089531 2.690391 2.2479496 0.05655072 3.8055308 0.05655072 0.36360365 5.841286 0.07995000 0.008533333 0.119100000 0.11056667 0.001065589 0.001065589 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153339 E001 6.7893690 0.2022037895 6.738341e-02 0.2191858093 18 31829197 31829937 741 - 0.667 1.095 1.650
ENSG00000153339 E002 134.9211504 1.3896980403 2.595290e-01 0.4984955790 18 31829938 31830497 560 - 1.858 2.352 1.652
ENSG00000153339 E003 98.3315794 1.3047707849 3.413772e-01 0.5793097698 18 31830498 31830589 92 - 1.761 2.124 1.220
ENSG00000153339 E004 52.1428993 0.8486502877 2.663382e-01 0.5058473974 18 31830590 31830594 5 - 1.494 1.845 1.191
ENSG00000153339 E005 51.7757151 0.8404769368 2.599864e-01 0.4990016111 18 31830595 31830597 3 - 1.490 1.847 1.213
ENSG00000153339 E006 90.3917493 1.2591215978 2.993298e-01 0.5397327282 18 31830598 31830691 94 - 1.710 2.127 1.402
ENSG00000153339 E007 138.3680344 1.4164536340 3.388890e-01 0.5769937250 18 31830692 31830920 229 - 1.898 2.295 1.329
ENSG00000153339 E008 73.9979965 0.9624712323 3.155783e-01 0.5555888976 18 31830921 31830984 64 - 1.651 1.967 1.068
ENSG00000153339 E009 48.6236939 0.8403793545 3.137516e-01 0.5539730499 18 31830985 31830989 5 - 1.480 1.768 0.980
ENSG00000153339 E010 106.8883072 0.0101150282 2.408540e-03 0.0197377585 18 31832084 31832173 90 - 1.824 2.090 0.895
ENSG00000153339 E011 0.8136113 0.0959072026 7.777533e-01   18 31832174 31832595 422 - 0.175 0.265 0.757
ENSG00000153339 E012 3.0606646 0.2678258665 1.928986e-01 0.4206779595 18 31833276 31833406 131 - 0.400 0.796 1.797
ENSG00000153339 E013 148.7569862 0.0073930566 2.079340e-02 0.0986478238 18 31839312 31839457 146 - 1.972 2.196 0.751
ENSG00000153339 E014 90.4885287 0.0298956388 7.712715e-01 0.8794272801 18 31846716 31846750 35 - 1.775 1.904 0.433
ENSG00000153339 E015 106.3679457 0.0161191667 8.232996e-01 0.9098346495 18 31846751 31846817 67 - 1.847 1.969 0.410
ENSG00000153339 E016 138.9031300 0.0302485556 4.833592e-01 0.6893191374 18 31849566 31849739 174 - 1.972 2.031 0.199
ENSG00000153339 E017 86.9691665 0.0183044014 8.618159e-01 0.9312951532 18 31852446 31852504 59 - 1.766 1.856 0.303
ENSG00000153339 E018 98.3554206 0.0190557026 4.573036e-01 0.6712766154 18 31852595 31852663 69 - 1.826 1.863 0.127
ENSG00000153339 E019 0.0000000       18 31852664 31852872 209 -      
ENSG00000153339 E020 119.5969446 0.0161696189 3.450309e-01 0.5826093199 18 31853849 31853945 97 - 1.911 1.942 0.103
ENSG00000153339 E021 111.6077327 0.0010668506 5.584935e-01 0.7422073315 18 31855660 31855807 148 - 1.874 1.991 0.394
ENSG00000153339 E022 88.8954373 1.3081626985 5.294054e-01 0.7216144389 18 31857540 31857720 181 - 1.760 1.932 0.581
ENSG00000153339 E023 101.1422027 1.3485825189 5.146067e-01 0.7114094053 18 31857721 31857982 262 - 1.813 1.995 0.613
ENSG00000153339 E024 104.6114609 0.0017079560 3.263052e-01 0.5654849262 18 31864627 31864781 155 - 1.841 1.976 0.455
ENSG00000153339 E025 133.6712700 0.0122375317 1.503659e-02 0.0782244399 18 31866849 31866975 127 - 1.971 1.894 -0.260
ENSG00000153339 E026 114.9265799 0.0230277866 4.342062e-03 0.0310573837 18 31867402 31867476 75 - 1.916 1.738 -0.600
ENSG00000153339 E027 0.1723744 0.0664575122 6.887943e-02   18 31870014 31870356 343 - 0.000 0.265 13.582
ENSG00000153339 E028 1.8754115 0.0101747215 9.070832e-01 0.9556587978 18 31870357 31870371 15 - 0.351 0.427 0.432
ENSG00000153339 E029 135.3388916 0.0245509237 8.023112e-02 0.2452717221 18 31870372 31870502 131 - 1.975 1.906 -0.229
ENSG00000153339 E030 145.9149407 0.0272892276 5.610546e-02 0.1938633676 18 31870926 31871065 140 - 2.008 1.939 -0.232
ENSG00000153339 E031 92.5937439 0.0556963539 1.009024e-01 0.2834197135 18 31871066 31871120 55 - 1.814 1.733 -0.277
ENSG00000153339 E032 109.4991281 0.0227914159 2.357445e-01 0.4717139210 18 31873430 31873538 109 - 1.877 1.873 -0.014
ENSG00000153339 E033 0.3088520 0.0273283316 2.168865e-01   18 31873570 31874479 910 - 0.051 0.264 2.749
ENSG00000153339 E034 122.6331903 0.0158605525 2.107383e-02 0.0995859347 18 31874480 31874704 225 - 1.936 1.849 -0.292
ENSG00000153339 E035 97.9155732 0.0410099616 7.079967e-02 0.2263188037 18 31890735 31890866 132 - 1.842 1.729 -0.384
ENSG00000153339 E036 1.0347667 0.4799861633 5.182301e-01   18 31890867 31891207 341 - 0.249 0.000 -10.751
ENSG00000153339 E037 84.5192702 0.0181257193 6.953802e-02 0.2238575243 18 31897786 31897891 106 - 1.775 1.706 -0.232
ENSG00000153339 E038 71.4868676 0.0039613003 3.109856e-04 0.0038409094 18 31900925 31901025 101 - 1.715 1.548 -0.567
ENSG00000153339 E039 85.0737414 0.0031190401 3.755931e-05 0.0006538903 18 31907460 31907610 151 - 1.791 1.614 -0.600
ENSG00000153339 E040 82.4660463 0.0145499667 1.399318e-04 0.0019794781 18 31908303 31908418 116 - 1.781 1.537 -0.828
ENSG00000153339 E041 156.5867090 0.0187516158 7.137486e-06 0.0001564820 18 31908754 31909010 257 - 2.058 1.791 -0.898
ENSG00000153339 E042 5.9702704 0.0067233569 8.229228e-04 0.0084656667 18 31909011 31909013 3 - 0.757 0.000 -13.354
ENSG00000153339 E043 82.6959612 0.0461653917 7.610125e-03 0.0475256266 18 31909667 31909760 94 - 1.779 1.586 -0.653
ENSG00000153339 E044 85.1612395 0.0110397523 1.969412e-05 0.0003775274 18 31913369 31913501 133 - 1.796 1.536 -0.881
ENSG00000153339 E045 45.5699592 0.0152943044 4.498483e-03 0.0319321991 18 31913502 31913522 21 - 1.526 1.323 -0.700
ENSG00000153339 E046 107.2490037 0.0196202165 1.040811e-02 0.0598975395 18 31916272 31916446 175 - 1.883 1.748 -0.456
ENSG00000153339 E047 77.6581043 0.0179961399 1.256732e-01 0.3249222801 18 31917578 31917667 90 - 1.734 1.693 -0.140
ENSG00000153339 E048 0.3503582 0.0696628415 2.192669e-01   18 31926468 31926605 138 - 0.051 0.265 2.753
ENSG00000153339 E049 83.0243186 0.0005025451 4.374401e-01 0.6568183134 18 31931329 31931523 195 - 1.757 1.805 0.162
ENSG00000153339 E050 0.0000000       18 31936339 31936396 58 -      
ENSG00000153339 E051 0.0000000       18 31939381 31939394 14 -      
ENSG00000153339 E052 0.3150090 0.0347284962 2.116502e-01   18 31939395 31939744 350 - 0.051 0.264 2.757
ENSG00000153339 E053 30.4698178 0.7416522146 4.891630e-01 0.6934540964 18 31942608 31942893 286 - 1.307 1.488 0.625
ENSG00000153339 E054 12.7825751 0.8701501821 8.020803e-01 0.8975526201 18 31942894 31942951 58 - 0.974 1.063 0.327
ENSG00000153339 E055 29.0823412 0.7825026168 7.908995e-01 0.8910178588 18 31942952 31943037 86 - 1.322 1.280 -0.148
ENSG00000153339 E056 27.5705981 0.7336492954 7.324917e-01 0.8556821069 18 31943038 31943114 77 - 1.298 1.271 -0.094
ENSG00000153339 E057 7.1744997 0.2873187051 5.355697e-01 0.7260139227 18 31943115 31943933 819 - 0.752 0.882 0.509
ENSG00000153339 E058 0.0000000       18 31953050 31953136 87 -