ENSG00000153317

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518721 ENSG00000153317 HEK293_OSMI2_6hA HEK293_TMG_6hB ASAP1 protein_coding protein_coding 10.24184 11.51962 11.19497 1.919879 0.4250332 -0.04120623 3.8168132 3.5323856 5.2318443 0.9381479 0.7687172 0.5653532 0.35265833 0.29366667 0.46480000 0.17113333 3.348160e-01 4.098511e-13 FALSE TRUE
ENST00000519483 ENSG00000153317 HEK293_OSMI2_6hA HEK293_TMG_6hB ASAP1 protein_coding protein_coding 10.24184 11.51962 11.19497 1.919879 0.4250332 -0.04120623 0.8067354 0.0000000 1.8871693 0.0000000 0.3371108 7.5677046 0.07055000 0.00000000 0.17043333 0.17043333 1.512259e-11 4.098511e-13 FALSE TRUE
ENST00000521075 ENSG00000153317 HEK293_OSMI2_6hA HEK293_TMG_6hB ASAP1 protein_coding nonsense_mediated_decay 10.24184 11.51962 11.19497 1.919879 0.4250332 -0.04120623 1.2101237 0.0000000 2.3525180 0.0000000 0.3877233 7.8841815 0.10593333 0.00000000 0.21230000 0.21230000 4.098511e-13 4.098511e-13 FALSE TRUE
ENST00000524124 ENSG00000153317 HEK293_OSMI2_6hA HEK293_TMG_6hB ASAP1 protein_coding protein_coding 10.24184 11.51962 11.19497 1.919879 0.4250332 -0.04120623 3.3039754 6.4508359 0.8943094 0.9645622 0.8943094 -2.8368324 0.36170417 0.56696667 0.07773333 -0.48923333 8.752699e-02 4.098511e-13 FALSE TRUE
MSTRG.32103.4 ENSG00000153317 HEK293_OSMI2_6hA HEK293_TMG_6hB ASAP1 protein_coding   10.24184 11.51962 11.19497 1.919879 0.4250332 -0.04120623 0.2342283 0.7563678 0.0000000 0.1893474 0.0000000 -6.2599651 0.02296667 0.06973333 0.00000000 -0.06973333 5.222159e-06 4.098511e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153317 E001 0.5363366 0.030783924 1.491204e-01   8 130052104 130052106 3 - 0.000 0.287 14.387
ENSG00000153317 E002 192.2861248 1.125281517 2.273330e-01 0.4621869222 8 130052107 130052841 735 - 1.944 2.461 1.730
ENSG00000153317 E003 498.1054032 1.579083119 3.910982e-01 0.6212456421 8 130052842 130054496 1655 - 2.466 2.837 1.236
ENSG00000153317 E004 126.9115726 1.130237455 4.370476e-01 0.6564729239 8 130054497 130054740 244 - 1.951 2.212 0.872
ENSG00000153317 E005 71.4761518 0.693467180 3.824491e-01 0.6142123696 8 130054741 130054805 65 - 1.724 1.955 0.780
ENSG00000153317 E006 107.6401404 0.025023734 4.929712e-01 0.6959494526 8 130057954 130058076 123 - 1.961 2.096 0.451
ENSG00000153317 E007 175.7622860 0.001775728 1.023025e-01 0.2859053354 8 130060579 130061069 491 - 2.219 2.277 0.191
ENSG00000153317 E008 48.0621206 0.003090251 5.729911e-01 0.7523096320 8 130076348 130076396 49 - 1.654 1.733 0.268
ENSG00000153317 E009 37.3809966 0.007437493 6.419415e-01 0.7981004209 8 130076397 130076406 10 - 1.541 1.618 0.261
ENSG00000153317 E010 63.7809730 0.020391078 4.757820e-01 0.6840547068 8 130079902 130079971 70 - 1.784 1.835 0.173
ENSG00000153317 E011 81.8116418 0.013575905 6.615296e-01 0.8108125183 8 130091973 130092143 171 - 1.875 1.957 0.274
ENSG00000153317 E012 113.4679523 0.013787671 3.505796e-01 0.5877476684 8 130112094 130112322 229 - 2.031 2.085 0.181
ENSG00000153317 E013 0.1614157 0.032164103 3.641245e-01   8 130112323 130112414 92 - 0.125 0.000 -13.037
ENSG00000153317 E014 0.0000000       8 130115577 130115627 51 -      
ENSG00000153317 E015 72.7075388 0.001839806 6.781152e-03 0.0436193905 8 130115628 130115735 108 - 1.877 1.866 -0.039
ENSG00000153317 E016 63.0569687 0.015043905 2.886213e-02 0.1239646699 8 130116678 130116745 68 - 1.828 1.780 -0.164
ENSG00000153317 E017 79.5411284 0.023972262 8.151296e-02 0.2478607530 8 130116880 130116995 116 - 1.921 1.888 -0.109
ENSG00000153317 E018 67.2840079 0.018920767 7.991258e-02 0.2446458455 8 130118161 130118246 86 - 1.844 1.821 -0.077
ENSG00000153317 E019 92.5045495 0.025865699 8.179554e-02 0.2483715929 8 130118489 130118675 187 - 1.987 1.953 -0.116
ENSG00000153317 E020 0.0000000       8 130118676 130118779 104 -      
ENSG00000153317 E021 57.2630881 0.032083884 3.754512e-01 0.6085445257 8 130124013 130124104 92 - 1.752 1.775 0.079
ENSG00000153317 E022 62.8246748 0.012561454 2.940272e-01 0.5346445693 8 130125956 130126089 134 - 1.785 1.825 0.135
ENSG00000153317 E023 76.9858135 0.005619038 6.062172e-02 0.2042205702 8 130127927 130128090 164 - 1.890 1.904 0.049
ENSG00000153317 E024 48.7249929 0.008027193 3.656886e-01 0.6004983540 8 130134296 130134344 49 - 1.672 1.728 0.190
ENSG00000153317 E025 60.8913597 0.002803408 2.531771e-01 0.4914029418 8 130136951 130137038 88 - 1.767 1.819 0.177
ENSG00000153317 E026 0.0000000       8 130152605 130152735 131 -      
ENSG00000153317 E027 44.7210849 0.006563504 6.958826e-01 0.8328590666 8 130152736 130152763 28 - 1.614 1.699 0.290
ENSG00000153317 E028 46.2470669 0.007085573 3.266725e-01 0.5658500839 8 130152764 130152805 42 - 1.648 1.695 0.162
ENSG00000153317 E029 49.4276715 0.001864707 7.898349e-02 0.2427994437 8 130159864 130159964 101 - 1.696 1.712 0.052
ENSG00000153317 E030 0.0000000       8 130159965 130160063 99 -      
ENSG00000153317 E031 0.0000000       8 130160785 130160793 9 -      
ENSG00000153317 E032 37.7684723 0.003508142 2.736057e-02 0.1193695094 8 130167536 130167622 87 - 1.609 1.580 -0.099
ENSG00000153317 E033 27.0228176 0.005991594 2.544668e-01 0.4929807193 8 130168992 130169067 76 - 1.437 1.451 0.049
ENSG00000153317 E034 0.1723744 0.050859505 6.450670e-01   8 130179118 130179263 146 - 0.000 0.118 12.808
ENSG00000153317 E035 33.1805862 0.010481318 8.019280e-03 0.0494053378 8 130179264 130179334 71 - 1.584 1.478 -0.363
ENSG00000153317 E036 22.6990268 0.013952461 2.056318e-02 0.0979084755 8 130179335 130179349 15 - 1.427 1.316 -0.387
ENSG00000153317 E037 53.2774184 0.010008081 6.586656e-04 0.0070844618 8 130180751 130180866 116 - 1.794 1.668 -0.425
ENSG00000153317 E038 29.0860668 0.001596965 1.231742e-04 0.0017769117 8 130180867 130180880 14 - 1.549 1.403 -0.500
ENSG00000153317 E039 37.1843192 0.002330365 9.858909e-06 0.0002071347 8 130187236 130187285 50 - 1.660 1.503 -0.538
ENSG00000153317 E040 44.1797291 0.015358330 6.202134e-04 0.0067543971 8 130188109 130188183 75 - 1.729 1.577 -0.518
ENSG00000153317 E041 0.0000000       8 130195113 130195372 260 -      
ENSG00000153317 E042 0.0000000       8 130208630 130208746 117 -      
ENSG00000153317 E043 39.4231096 0.019523629 3.631898e-03 0.0271004781 8 130214556 130214617 62 - 1.671 1.539 -0.451
ENSG00000153317 E044 30.8994424 0.015717030 1.303710e-02 0.0706017056 8 130214618 130214644 27 - 1.554 1.458 -0.328
ENSG00000153317 E045 31.6804491 0.008453043 6.878812e-04 0.0073364347 8 130214645 130214701 57 - 1.588 1.450 -0.474
ENSG00000153317 E046 33.3935624 0.033542430 3.373596e-02 0.1381647906 8 130236922 130236994 73 - 1.590 1.493 -0.332
ENSG00000153317 E047 0.0000000       8 130236995 130236996 2 -      
ENSG00000153317 E048 0.1308682 0.032649190 6.479770e-01   8 130246966 130247042 77 - 0.000 0.118 12.803
ENSG00000153317 E049 0.8995767 0.016013646 7.020857e-01   8 130290001 130290140 140 - 0.301 0.286 -0.100
ENSG00000153317 E050 0.0000000       8 130340842 130340937 96 -      
ENSG00000153317 E051 29.8081713 0.054907740 5.623505e-02 0.1941854573 8 130358017 130358143 127 - 1.551 1.426 -0.429
ENSG00000153317 E052 0.0000000       8 130360689 130361161 473 -      
ENSG00000153317 E053 2.6387325 0.009233542 5.738837e-01 0.7529253024 8 130361670 130361771 102 - 0.477 0.646 0.775
ENSG00000153317 E054 0.1779838 0.058675365 3.643990e-01   8 130386671 130386877 207 - 0.125 0.000 -13.040
ENSG00000153317 E055 15.0520604 0.052313554 2.565548e-01 0.4953150247 8 130401885 130401970 86 - 1.227 1.192 -0.125
ENSG00000153317 E056 0.3032425 0.027442404 3.044280e-01   8 130427734 130427802 69 - 0.000 0.210 13.805
ENSG00000153317 E057 0.1723744 0.050859505 6.450670e-01   8 130436245 130436326 82 - 0.000 0.118 12.808
ENSG00000153317 E058 0.8631121 0.208099857 8.601262e-01   8 130440289 130440373 85 - 0.220 0.293 0.551
ENSG00000153317 E059 10.3785075 0.011179803 8.933168e-01 0.9482976841 8 130443460 130443674 215 - 1.001 1.117 0.422