ENSG00000153310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000519110 ENSG00000153310 HEK293_OSMI2_6hA HEK293_TMG_6hB CYRIB protein_coding protein_coding 38.74312 11.25644 62.84325 2.209042 2.102244 2.479956 1.973033 0.1204199 2.322143 0.1204199 1.0917048 4.160421 0.0905625 0.0175000 0.03813333 0.02063333 0.59575982 0.01209685 FALSE TRUE
ENST00000519540 ENSG00000153310 HEK293_OSMI2_6hA HEK293_TMG_6hB CYRIB protein_coding protein_coding 38.74312 11.25644 62.84325 2.209042 2.102244 2.479956 13.795981 5.1953554 18.431852 1.0386867 0.8178827 1.824915 0.3580542 0.4620667 0.29383333 -0.16823333 0.01209685 0.01209685 FALSE TRUE
ENST00000519824 ENSG00000153310 HEK293_OSMI2_6hA HEK293_TMG_6hB CYRIB protein_coding protein_coding 38.74312 11.25644 62.84325 2.209042 2.102244 2.479956 4.458440 1.6203465 5.485613 0.4822850 0.3285406 1.753102 0.1255458 0.1364667 0.08716667 -0.04930000 0.38008238 0.01209685 FALSE TRUE
MSTRG.32089.12 ENSG00000153310 HEK293_OSMI2_6hA HEK293_TMG_6hB CYRIB protein_coding   38.74312 11.25644 62.84325 2.209042 2.102244 2.479956 7.301200 1.2237110 16.896936 0.3323093 3.5305673 3.776539 0.1395750 0.1155667 0.26563333 0.15006667 0.28627089 0.01209685 FALSE TRUE
MSTRG.32089.13 ENSG00000153310 HEK293_OSMI2_6hA HEK293_TMG_6hB CYRIB protein_coding   38.74312 11.25644 62.84325 2.209042 2.102244 2.479956 7.212015 1.1276896 14.597285 0.3832613 0.8286743 3.682509 0.1573417 0.1033333 0.23320000 0.12986667 0.17727807 0.01209685 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153310 E001 123.9323940 0.0074007792 3.051152e-05 5.477913e-04 8 129839593 129841469 1877 - 1.934 2.178 0.818
ENSG00000153310 E002 10.9051486 0.0036586778 7.586942e-02 2.365065e-01 8 129841470 129841483 14 - 0.928 1.145 0.798
ENSG00000153310 E003 11.4177303 0.0032691707 1.863334e-01 4.122099e-01 8 129841484 129841496 13 - 0.958 1.124 0.607
ENSG00000153310 E004 9.7145911 0.0033773341 4.316173e-01 6.524531e-01 8 129841497 129841502 6 - 0.912 1.024 0.417
ENSG00000153310 E005 93.4364721 0.0209725616 2.596381e-03 2.094054e-02 8 129841503 129841681 179 - 1.803 2.064 0.875
ENSG00000153310 E006 70.3820652 0.0148935204 4.708906e-08 1.889604e-06 8 129841682 129841725 44 - 1.634 2.046 1.389
ENSG00000153310 E007 376.9467467 0.0028850349 1.121586e-02 6.325499e-02 8 129841726 129842079 354 - 2.450 2.544 0.315
ENSG00000153310 E008 296.1108812 0.0003792831 3.726305e-01 6.061421e-01 8 129842080 129842205 126 - 2.368 2.361 -0.025
ENSG00000153310 E009 209.4745114 0.0002720282 9.299883e-02 2.692949e-01 8 129846804 129846874 71 - 2.224 2.187 -0.123
ENSG00000153310 E010 1.7154009 0.0189896613 1.818158e-01 4.063820e-01 8 129846875 129847317 443 - 0.315 0.571 1.354
ENSG00000153310 E011 349.6549621 0.0002821325 4.770610e-03 3.337972e-02 8 129849243 129849369 127 - 2.448 2.393 -0.182
ENSG00000153310 E012 24.1777087 0.0447299922 7.682595e-01 8.775804e-01 8 129849370 129850553 1184 - 1.302 1.261 -0.143
ENSG00000153310 E013 6.3748085 0.0614374550 2.021396e-01 4.322765e-01 8 129850554 129850834 281 - 0.814 0.569 -1.030
ENSG00000153310 E014 299.9553890 0.0001852508 3.937783e-03 2.879957e-02 8 129850835 129850914 80 - 2.381 2.321 -0.201
ENSG00000153310 E015 5.3653851 0.1031570212 1.995071e-01 4.291050e-01 8 129850915 129852161 1247 - 0.654 0.899 0.981
ENSG00000153310 E016 330.1224155 0.0002245777 8.211856e-02 2.489698e-01 8 129852162 129852278 117 - 2.416 2.389 -0.092
ENSG00000153310 E017 231.6037240 0.0009324439 6.394546e-01 7.965766e-01 8 129854266 129854343 78 - 2.257 2.257 -0.002
ENSG00000153310 E018 0.1614157 0.0338719973 1.000000e+00   8 129855583 129855610 28 - 0.062 0.000 -7.831
ENSG00000153310 E019 197.4809573 0.0004578511 8.373146e-01 9.179574e-01 8 129855611 129855687 77 - 2.184 2.206 0.074
ENSG00000153310 E020 114.9230994 0.0003827388 7.611927e-01 8.733028e-01 8 129855688 129855697 10 - 1.956 1.960 0.011
ENSG00000153310 E021 151.4224456 0.0003377054 6.198853e-01 7.837546e-01 8 129855698 129855747 50 - 2.078 2.076 -0.006
ENSG00000153310 E022 98.8202067 0.0011601288 1.776873e-01 4.006983e-01 8 129862229 129862233 5 - 1.904 1.856 -0.159
ENSG00000153310 E023 114.4288554 0.0004455850 3.514716e-01 5.886039e-01 8 129862234 129862249 16 - 1.962 1.939 -0.077
ENSG00000153310 E024 147.6414996 0.0003094500 3.630735e-01 5.982105e-01 8 129862250 129862293 44 - 2.070 2.053 -0.058
ENSG00000153310 E025 135.3109203 0.0004380332 3.387760e-01 5.769119e-01 8 129862294 129862325 32 - 2.033 2.012 -0.072
ENSG00000153310 E026 112.9453010 0.0005181386 2.137061e-01 4.460256e-01 8 129862326 129862334 9 - 1.957 1.919 -0.129
ENSG00000153310 E027 120.4363166 0.0003857594 5.064619e-01 7.052509e-01 8 129871375 129871380 6 - 1.981 1.969 -0.038
ENSG00000153310 E028 149.2068772 0.0003203248 1.946807e-01 4.229297e-01 8 129871381 129871426 46 - 2.077 2.045 -0.108
ENSG00000153310 E029 100.7385261 0.0035367928 1.767395e-01 3.994235e-01 8 129871427 129871432 6 - 1.912 1.856 -0.189
ENSG00000153310 E030 158.9584159 0.0004821867 9.796560e-03 5.724593e-02 8 129871433 129871496 64 - 2.112 2.031 -0.270
ENSG00000153310 E031 150.2765528 0.0002970941 1.094829e-01 2.982229e-01 8 129879389 129879471 83 - 2.080 2.037 -0.146
ENSG00000153310 E032 1.9708603 0.0107153689 6.015467e-01 7.711699e-01 8 129879597 129879789 193 - 0.375 0.484 0.578
ENSG00000153310 E033 4.0087538 0.0259351417 9.758018e-01 9.896894e-01 8 129880376 129880458 83 - 0.622 0.643 0.090
ENSG00000153310 E034 0.1614157 0.0338719973 1.000000e+00   8 129894487 129894564 78 - 0.062 0.000 -7.831
ENSG00000153310 E035 1.3253852 0.1050288534 6.620975e-01   8 129896672 129896748 77 - 0.283 0.375 0.581
ENSG00000153310 E036 1.0517650 0.1475639168 5.279153e-01   8 129896749 129896854 106 - 0.244 0.373 0.852
ENSG00000153310 E037 0.6316833 0.0247747794 7.586417e-01   8 129902961 129903311 351 - 0.164 0.226 0.574
ENSG00000153310 E038 128.1972164 0.0003814835 1.570769e-01 3.723629e-01 8 129903312 129903350 39 - 2.013 1.972 -0.136
ENSG00000153310 E039 51.0105342 0.0008303885 1.764599e-01 3.990443e-01 8 129904499 129904585 87 - 1.591 1.688 0.332
ENSG00000153310 E040 0.0000000       8 129912360 129912417 58 -      
ENSG00000153310 E041 0.5067846 0.0217681645 5.234361e-01   8 129912470 129912515 46 - 0.115 0.226 1.167
ENSG00000153310 E042 120.4605193 0.0034747263 7.787369e-02 2.405648e-01 8 129939608 129939872 265 - 1.957 2.063 0.354
ENSG00000153310 E043 0.0000000       8 129948966 129949067 102 -      
ENSG00000153310 E044 0.0000000       8 129970509 129970675 167 -      
ENSG00000153310 E045 0.0000000       8 129970676 129970942 267 -      
ENSG00000153310 E046 5.6303355 0.1162449839 5.229119e-02 1.850398e-01 8 129970943 129970995 53 - 0.644 0.998 1.395
ENSG00000153310 E047 4.6572635 0.1329215382 2.460166e-02 1.109882e-01 8 130016370 130016606 237 - 0.529 1.002 1.924
ENSG00000153310 E048 1.1438171 0.0186598063 2.640902e-02   8 130016607 130016697 91 - 0.163 0.572 2.581
ENSG00000153310 E049 0.0000000       8 130017018 130017129 112 -