ENSG00000153250

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348849 ENSG00000153250 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMS1 protein_coding protein_coding 11.32569 4.350896 15.83007 1.109003 1.166856 1.860882 7.5053721 3.5320173 9.390328 0.9257779 1.175230 1.408140 0.72000417 0.80853333 0.58976667 -0.218766667 1.824890e-01 7.545446e-15 FALSE TRUE
ENST00000409289 ENSG00000153250 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMS1 protein_coding protein_coding 11.32569 4.350896 15.83007 1.109003 1.166856 1.860882 0.8877738 0.0000000 3.650588 0.0000000 0.300407 8.515932 0.05415833 0.00000000 0.23143333 0.231433333 7.545446e-15 7.545446e-15 FALSE TRUE
ENST00000409972 ENSG00000153250 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMS1 protein_coding protein_coding 11.32569 4.350896 15.83007 1.109003 1.166856 1.860882 1.5071656 0.3279476 1.047296 0.1733233 0.203563 1.645508 0.10929583 0.07106667 0.06613333 -0.004933333 9.748913e-01 7.545446e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153250 E001 389.6215763 1.711959726 0.366781386 0.60132720 2 160272151 160274414 2264 - 2.396 2.775 1.261
ENSG00000153250 E002 24.0535672 0.423217898 0.179785767 0.40368303 2 160274415 160274459 45 - 1.193 1.605 1.427
ENSG00000153250 E003 11.9639775 0.149385129 0.037976770 0.14955659 2 160274460 160274479 20 - 0.889 1.353 1.673
ENSG00000153250 E004 8.8353362 0.080286577 0.044879876 0.16732137 2 160274480 160274489 10 - 0.798 1.214 1.543
ENSG00000153250 E005 10.3124660 0.135979341 0.074706639 0.23422348 2 160274490 160274517 28 - 0.860 1.267 1.486
ENSG00000153250 E006 7.3917882 0.117871248 0.127430540 0.32777421 2 160274518 160274519 2 - 0.759 1.108 1.319
ENSG00000153250 E007 7.1041362 0.322628502 0.314108291 0.55434308 2 160274520 160274539 20 - 0.741 1.100 1.363
ENSG00000153250 E008 38.5257176 0.648672918 0.492878340 0.69588590 2 160274540 160274764 225 - 1.480 1.646 0.567
ENSG00000153250 E009 0.8746386 0.021805734 0.293740960   2 160275399 160275629 231 - 0.182 0.446 1.782
ENSG00000153250 E010 42.5946002 0.001401020 0.020535037 0.09780462 2 160275630 160275714 85 - 1.579 1.574 -0.015
ENSG00000153250 E011 0.6544085 0.019387492 0.934156910   2 160276642 160276685 44 - 0.182 0.204 0.204
ENSG00000153250 E012 50.9775632 0.009173187 0.003992561 0.02911494 2 160277303 160277383 81 - 1.659 1.599 -0.202
ENSG00000153250 E013 8.1976292 0.166586164 0.231587776 0.46695544 2 160277384 160278547 1164 - 0.925 0.772 -0.594
ENSG00000153250 E014 62.1381779 0.024276948 0.074889642 0.23459721 2 160278548 160278658 111 - 1.729 1.724 -0.017
ENSG00000153250 E015 2.0825875 0.152560261 0.277390277 0.51742895 2 160278659 160279766 1108 - 0.468 0.338 -0.719
ENSG00000153250 E016 49.7581696 0.026550145 0.042928161 0.16235055 2 160281314 160281364 51 - 1.642 1.608 -0.115
ENSG00000153250 E017 3.3916943 0.258352750 0.879044478 0.94078556 2 160281365 160282256 892 - 0.543 0.672 0.568
ENSG00000153250 E018 7.2737774 0.304884063 0.821343205 0.90876671 2 160282257 160282304 48 - 0.848 0.868 0.075
ENSG00000153250 E019 8.5703527 0.453158563 0.213518020 0.44581734 2 160282305 160284260 1956 - 0.954 0.733 -0.858
ENSG00000153250 E020 3.7116471 0.114453321 0.174437966 0.39643995 2 160284261 160284774 514 - 0.653 0.447 -0.961
ENSG00000153250 E021 62.7698183 0.025413765 0.019841453 0.09533937 2 160284775 160284868 94 - 1.742 1.698 -0.150
ENSG00000153250 E022 57.9089340 0.019214863 0.011952907 0.06625362 2 160284995 160285044 50 - 1.710 1.665 -0.154
ENSG00000153250 E023 20.9320733 0.002181028 0.020688170 0.09829963 2 160286969 160286977 9 - 1.287 1.220 -0.238
ENSG00000153250 E024 67.1437902 0.011395297 0.005017774 0.03472002 2 160286978 160287084 107 - 1.773 1.730 -0.145
ENSG00000153250 E025 54.8544876 0.015409123 0.049072774 0.17738039 2 160300651 160300730 80 - 1.676 1.680 0.013
ENSG00000153250 E026 0.1779838 0.145049719 1.000000000   2 160302504 160302824 321 - 0.070 0.000 -11.887
ENSG00000153250 E027 48.1253798 0.030897735 0.070279234 0.22532104 2 160303330 160303407 78 - 1.627 1.587 -0.136
ENSG00000153250 E028 49.3328377 0.014860695 0.023264856 0.10679861 2 160303408 160303487 80 - 1.639 1.605 -0.116
ENSG00000153250 E029 44.9467697 0.023073984 0.001896196 0.01637600 2 160313156 160313247 92 - 1.620 1.483 -0.468
ENSG00000153250 E030 41.9160259 0.023194991 0.036277571 0.14498332 2 160318169 160318227 59 - 1.571 1.532 -0.134
ENSG00000153250 E031 0.0000000       2 160366913 160367215 303 -      
ENSG00000153250 E032 49.2375026 0.042204563 0.119210238 0.31457207 2 160367216 160367388 173 - 1.632 1.618 -0.046
ENSG00000153250 E033 10.7289088 0.054669178 0.580747424 0.75766215 2 160367389 160367391 3 - 0.987 1.063 0.278
ENSG00000153250 E034 0.0000000       2 160401968 160402102 135 -      
ENSG00000153250 E035 7.9839524 0.081600667 0.480475220 0.68740693 2 160407464 160407809 346 - 0.807 1.101 1.103
ENSG00000153250 E036 1.3024724 0.102881001 0.707437765   2 160407810 160407889 80 - 0.273 0.445 1.032
ENSG00000153250 E037 0.0000000       2 160408509 160408609 101 -      
ENSG00000153250 E038 0.0000000       2 160416138 160416178 41 -      
ENSG00000153250 E039 0.6238610 0.018950802 0.374357929   2 160432368 160432477 110 - 0.129 0.342 1.787
ENSG00000153250 E040 0.1779838 0.145049719 1.000000000   2 160492887 160492969 83 - 0.070 0.000 -11.887
ENSG00000153250 E041 17.7963989 0.122322568 0.831941964 0.91496752 2 160493289 160493807 519 - 1.180 1.271 0.319