ENSG00000153201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283195 ENSG00000153201 HEK293_OSMI2_6hA HEK293_TMG_6hB RANBP2 protein_coding protein_coding 14.35314 6.521333 24.62012 1.074599 0.4947053 1.914974 9.9277252 1.793183 21.9253002 0.3300056 0.8026853 3.604637 0.47750833 0.27813333 0.8914333 0.613300000 8.772823e-07 8.772823e-07 FALSE TRUE
MSTRG.18998.1 ENSG00000153201 HEK293_OSMI2_6hA HEK293_TMG_6hB RANBP2 protein_coding   14.35314 6.521333 24.62012 1.074599 0.4947053 1.914974 1.0921038 0.122624 0.8559670 0.1226240 0.4280005 2.706970 0.05717083 0.02576667 0.0348000 0.009033333 8.334119e-01 8.772823e-07 FALSE TRUE
MSTRG.18998.7 ENSG00000153201 HEK293_OSMI2_6hA HEK293_TMG_6hB RANBP2 protein_coding   14.35314 6.521333 24.62012 1.074599 0.4947053 1.914974 1.9455160 4.242875 0.4509433 1.0325953 0.4509433 -3.205777 0.32963333 0.63453333 0.0177000 -0.616833333 6.156148e-03 8.772823e-07 FALSE TRUE
MSTRG.18998.8 ENSG00000153201 HEK293_OSMI2_6hA HEK293_TMG_6hB RANBP2 protein_coding   14.35314 6.521333 24.62012 1.074599 0.4947053 1.914974 0.5571544 0.000000 0.0000000 0.0000000 0.0000000 0.000000 0.09109583 0.00000000 0.0000000 0.000000000   8.772823e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153201 E001 0.1426347 0.0324369222 1.000000e+00   2 108719470 108719481 12 + 0.069 0.000 -8.426
ENSG00000153201 E002 0.1426347 0.0324369222 1.000000e+00   2 108719482 108719488 7 + 0.069 0.000 -8.407
ENSG00000153201 E003 18.2499193 0.0022446431 8.457563e-04 8.660690e-03 2 108719489 108719552 64 + 1.264 0.973 -1.047
ENSG00000153201 E004 26.1953496 0.0030333867 2.186704e-04 2.879203e-03 2 108719553 108719606 54 + 1.409 1.133 -0.969
ENSG00000153201 E005 29.7117755 0.0020554150 1.702858e-04 2.337411e-03 2 108719607 108719678 72 + 1.459 1.204 -0.889
ENSG00000153201 E006 18.4713308 0.0051760650 7.174730e-05 1.133322e-03 2 108729132 108729134 3 + 1.276 0.881 -1.438
ENSG00000153201 E007 27.2314201 0.0373406897 1.172691e-02 6.534434e-02 2 108729135 108729199 65 + 1.426 1.155 -0.951
ENSG00000153201 E008 27.9892450 0.0012289674 3.951844e-04 4.684588e-03 2 108730774 108730816 43 + 1.437 1.204 -0.815
ENSG00000153201 E009 40.4163078 0.0008612739 3.584652e-07 1.153822e-05 2 108730817 108730885 69 + 1.601 1.292 -1.064
ENSG00000153201 E010 49.4687802 0.0026817067 3.800838e-10 2.386209e-08 2 108731322 108731409 88 + 1.698 1.304 -1.352
ENSG00000153201 E011 44.3643933 0.0009239534 9.820332e-08 3.651671e-06 2 108731410 108731474 65 + 1.640 1.330 -1.067
ENSG00000153201 E012 0.3206185 0.0274424043 7.436330e-01   2 108731475 108731898 424 + 0.129 0.000 -9.409
ENSG00000153201 E013 82.3171625 0.0008157663 1.604920e-14 2.286513e-12 2 108735532 108735762 231 + 1.909 1.560 -1.181
ENSG00000153201 E014 56.6426838 0.0044026558 1.383995e-07 4.980591e-06 2 108736104 108736249 146 + 1.744 1.445 -1.021
ENSG00000153201 E015 52.9293023 0.0007083086 2.611009e-11 2.091554e-09 2 108740489 108740681 193 + 1.723 1.342 -1.306
ENSG00000153201 E016 44.7433782 0.0010679395 4.310517e-15 6.648728e-13 2 108746711 108746798 88 + 1.664 1.093 -1.986
ENSG00000153201 E017 53.8113785 0.0015569598 1.202964e-16 2.274955e-14 2 108748920 108749031 112 + 1.743 1.187 -1.917
ENSG00000153201 E018 69.3485501 0.0078127340 1.027610e-09 5.986685e-08 2 108749032 108749129 98 + 1.838 1.445 -1.337
ENSG00000153201 E019 79.6710990 0.0008619746 3.600724e-12 3.365359e-10 2 108751264 108751445 182 + 1.887 1.575 -1.058
ENSG00000153201 E020 21.7142742 0.0040643673 3.787928e-06 9.061519e-05 2 108751528 108751550 23 + 1.350 0.913 -1.571
ENSG00000153201 E021 58.7044554 0.0012440186 7.260875e-13 7.620912e-11 2 108751551 108751703 153 + 1.767 1.354 -1.412
ENSG00000153201 E022 5.5280708 0.0897798233 8.262072e-01 9.116002e-01 2 108751704 108751870 167 + 0.755 0.759 0.016
ENSG00000153201 E023 73.4014679 0.0006109469 1.550657e-12 1.541787e-10 2 108751871 108751994 124 + 1.855 1.523 -1.125
ENSG00000153201 E024 59.4286276 0.0006248179 1.623264e-10 1.103111e-08 2 108752998 108753159 162 + 1.767 1.437 -1.122
ENSG00000153201 E025 47.7783593 0.0008692980 2.214842e-08 9.622182e-07 2 108753426 108753563 138 + 1.672 1.354 -1.091
ENSG00000153201 E026 59.4697957 0.0030996479 7.015647e-09 3.405998e-07 2 108753825 108753971 147 + 1.766 1.446 -1.093
ENSG00000153201 E027 82.3578412 0.0004693468 3.742772e-12 3.492356e-10 2 108754905 108755084 180 + 1.902 1.608 -0.993
ENSG00000153201 E028 70.6272677 0.0014211693 5.571445e-11 4.148003e-09 2 108755176 108755259 84 + 1.836 1.515 -1.089
ENSG00000153201 E029 40.4729498 0.0090750043 1.364182e-05 2.743598e-04 2 108758413 108758416 4 + 1.597 1.278 -1.102
ENSG00000153201 E030 64.3038213 0.0038436416 5.609469e-07 1.715774e-05 2 108758417 108758548 132 + 1.787 1.523 -0.894
ENSG00000153201 E031 43.7927603 0.0139318523 3.693448e-03 2.743863e-02 2 108762101 108762195 95 + 1.614 1.410 -0.700
ENSG00000153201 E032 864.3393447 0.0152886370 1.143827e-05 2.353383e-04 2 108763237 108766047 2811 + 2.898 2.712 -0.618
ENSG00000153201 E033 112.1984817 0.0006013930 1.137081e-02 6.388784e-02 2 108766048 108766164 117 + 1.989 1.953 -0.122
ENSG00000153201 E034 866.3563927 0.0024888310 9.451057e-01 9.748380e-01 2 108766165 108768388 2224 + 2.848 2.911 0.209
ENSG00000153201 E035 199.0651822 0.0002824661 2.959815e-06 7.350755e-05 2 108771701 108771871 171 + 2.176 2.372 0.654
ENSG00000153201 E036 153.9023723 0.0004030404 3.519259e-05 6.179827e-04 2 108772489 108772581 93 + 2.064 2.261 0.661
ENSG00000153201 E037 225.9950498 0.0031079953 1.057375e-03 1.034907e-02 2 108772868 108773046 179 + 2.233 2.414 0.605
ENSG00000153201 E038 240.8838710 0.0002218418 5.140749e-09 2.579839e-07 2 108775732 108775936 205 + 2.252 2.464 0.706
ENSG00000153201 E039 149.0840986 0.0003338221 1.527893e-08 6.875233e-07 2 108777130 108777231 102 + 2.034 2.278 0.817
ENSG00000153201 E040 209.7018700 0.0043490766 3.224473e-07 1.051439e-05 2 108781269 108781429 161 + 2.170 2.439 0.896
ENSG00000153201 E041 100.8103342 0.0082014795 1.219029e-03 1.157437e-02 2 108782128 108782131 4 + 1.862 2.108 0.824
ENSG00000153201 E042 305.4434631 0.0023146270 1.783065e-12 1.749309e-10 2 108782132 108782401 270 + 2.330 2.608 0.929
ENSG00000153201 E043 290.6945970 0.0193715179 4.449471e-07 1.397748e-05 2 108782528 108782862 335 + 2.259 2.664 1.350
ENSG00000153201 E044 390.6274378 0.7513600868 1.396116e-01 3.468991e-01 2 108783596 108785809 2214 + 2.333 2.853 1.733