ENSG00000153006

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000495198 ENSG00000153006 HEK293_OSMI2_6hA HEK293_TMG_6hB SREK1IP1 protein_coding retained_intron 11.67213 3.896407 18.7719 0.506091 0.5948154 2.265429 2.029102 1.9270833 3.928603 0.4394140 0.4708834 1.023798 0.2856792 0.4822000 0.2081667 -0.2740333 1.845371e-03 2.117535e-07 FALSE FALSE
ENST00000510616 ENSG00000153006 HEK293_OSMI2_6hA HEK293_TMG_6hB SREK1IP1 protein_coding processed_transcript 11.67213 3.896407 18.7719 0.506091 0.5948154 2.265429 2.673374 0.7613356 2.011842 0.3128197 0.3173951 1.390239 0.2164833 0.1968000 0.1080000 -0.0888000 7.181074e-01 2.117535e-07   FALSE
ENST00000513458 ENSG00000153006 HEK293_OSMI2_6hA HEK293_TMG_6hB SREK1IP1 protein_coding protein_coding 11.67213 3.896407 18.7719 0.506091 0.5948154 2.265429 6.395757 0.9141741 12.138426 0.1419528 0.4994769 3.716461 0.4467458 0.2396333 0.6464333 0.4068000 2.117535e-07 2.117535e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000153006 E001 904.8988407 0.0013508828 4.080140e-41 7.450555e-38 5 64718148 64724431 6284 - 2.835 2.576 -0.862
ENSG00000153006 E002 53.5011397 0.0006814364 1.313185e-05 2.658984e-04 5 64724432 64724573 142 - 1.553 1.763 0.715
ENSG00000153006 E003 0.1614157 0.0331146196 8.126297e-01   5 64727671 64728106 436 - 0.054 0.001 -6.748
ENSG00000153006 E004 20.1493671 0.0022906785 1.923133e-10 1.283270e-08 5 64728107 64728179 73 - 1.071 1.564 1.725
ENSG00000153006 E005 84.1594297 0.0005473217 4.980556e-09 2.506112e-07 5 64741057 64741135 79 - 1.742 1.968 0.761
ENSG00000153006 E006 109.2849800 0.0005436761 1.552417e-07 5.505036e-06 5 64741136 64741200 65 - 1.863 2.036 0.581
ENSG00000153006 E007 0.9520415 0.0680465893 3.711200e-03   5 64741201 64742121 921 - 0.101 0.620 3.594
ENSG00000153006 E008 112.7189128 0.0004576266 4.511326e-05 7.623912e-04 5 64754315 64754362 48 - 1.886 2.010 0.417
ENSG00000153006 E009 1.2457534 0.0250725299 3.576799e-01   5 64754623 64754770 148 - 0.252 0.412 1.008
ENSG00000153006 E010 3.1518305 0.1060992338 1.717837e-01 3.929265e-01 5 64764975 64765044 70 - 0.455 0.698 1.106
ENSG00000153006 E011 5.9842729 0.0051383562 8.010032e-03 4.935633e-02 5 64765045 64765121 77 - 0.645 0.987 1.349
ENSG00000153006 E012 129.6962112 0.0003722727 9.145366e-07 2.628679e-05 5 64768505 64768691 187 - 1.945 2.086 0.476