ENSG00000152952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282903 ENSG00000152952 HEK293_OSMI2_6hA HEK293_TMG_6hB PLOD2 protein_coding protein_coding 20.70236 5.177115 37.37058 1.192893 1.297054 2.849285 6.855776 2.568115 8.373406 0.8392033 0.6816162 1.701220 0.35326250 0.4674667 0.2239000 -0.2435667 0.02704684 0.02704684 FALSE TRUE
ENST00000360060 ENSG00000152952 HEK293_OSMI2_6hA HEK293_TMG_6hB PLOD2 protein_coding protein_coding 20.70236 5.177115 37.37058 1.192893 1.297054 2.849285 11.648152 2.431505 24.196203 0.3622363 0.3070927 3.309534 0.56910417 0.4954333 0.6490667 0.1536333 0.32339589 0.02704684 FALSE TRUE
ENST00000469350 ENSG00000152952 HEK293_OSMI2_6hA HEK293_TMG_6hB PLOD2 protein_coding protein_coding 20.70236 5.177115 37.37058 1.192893 1.297054 2.849285 0.814107 0.000000 2.149343 0.0000000 1.1460404 7.754449 0.02097917 0.0000000 0.0558000 0.0558000 0.56319188 0.02704684 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152952 E001 0.1426347 0.0327832715 1.000000e+00   3 146069440 146069443 4 - 0.053 0.000 -7.724
ENSG00000152952 E002 291.3587221 0.0027473258 2.761401e-08 1.174056e-06 3 146069444 146070180 737 - 2.279 2.473 0.645
ENSG00000152952 E003 131.2896058 0.0003222272 9.490390e-01 9.766485e-01 3 146070181 146070240 60 - 1.970 1.973 0.010
ENSG00000152952 E004 367.8665294 0.0008022587 8.046716e-03 4.952126e-02 3 146070241 146070872 632 - 2.403 2.478 0.251
ENSG00000152952 E005 192.1514641 0.0003166502 1.199505e-01 3.157704e-01 3 146071042 146071167 126 - 2.126 2.186 0.201
ENSG00000152952 E006 0.2852693 0.3215355068 1.000000e+00   3 146071168 146071170 3 - 0.099 0.000 -8.682
ENSG00000152952 E007 210.1499118 0.0002351615 5.442450e-02 1.900817e-01 3 146071277 146071423 147 - 2.163 2.233 0.231
ENSG00000152952 E008 0.1426347 0.0327832715 1.000000e+00   3 146072557 146072560 4 - 0.053 0.000 -7.708
ENSG00000152952 E009 159.0014599 0.0039551795 6.472009e-01 8.015987e-01 3 146072561 146072665 105 - 2.051 2.083 0.110
ENSG00000152952 E010 107.7397001 0.0009182126 3.937795e-01 6.233497e-01 3 146073287 146073352 66 - 1.882 1.929 0.160
ENSG00000152952 E011 0.9770522 0.0157190332 2.451871e-01   3 146073353 146073657 305 - 0.183 0.413 1.599
ENSG00000152952 E012 3.6699738 0.1107437221 1.719027e-01 3.930716e-01 3 146075925 146076781 857 - 0.599 0.252 -1.913
ENSG00000152952 E013 122.7976067 0.0005003651 9.353989e-01 9.698646e-01 3 146076782 146076895 114 - 1.941 1.942 0.005
ENSG00000152952 E014 12.0831283 0.0030851423 6.828126e-01 8.244562e-01 3 146076896 146077861 966 - 0.967 1.023 0.207
ENSG00000152952 E015 37.5314012 0.0009523291 7.206856e-03 4.561025e-02 3 146077862 146077924 63 - 1.402 1.601 0.682
ENSG00000152952 E016 182.4711974 0.0007988117 3.613071e-01 5.967638e-01 3 146079116 146079257 142 - 2.117 2.085 -0.106
ENSG00000152952 E017 125.6776144 0.0003306812 1.031650e-02 5.947987e-02 3 146081738 146081790 53 - 1.965 1.851 -0.387
ENSG00000152952 E018 136.1520200 0.0007027608 1.034501e-01 2.879658e-01 3 146081791 146081863 73 - 1.994 1.926 -0.228
ENSG00000152952 E019 162.8722000 0.0016213444 1.259704e-01 3.254627e-01 3 146085169 146085273 105 - 2.071 2.007 -0.211
ENSG00000152952 E020 7.9573389 0.0232734505 4.205999e-03 3.029672e-02 3 146085274 146086735 1462 - 0.871 0.254 -3.019
ENSG00000152952 E021 165.5681785 0.0010828477 1.450276e-01 3.549463e-01 3 146086787 146086908 122 - 2.078 2.021 -0.190
ENSG00000152952 E022 174.9519844 0.0006454752 2.489397e-01 4.866983e-01 3 146088586 146088711 126 - 2.101 2.062 -0.132
ENSG00000152952 E023 0.1426347 0.0327832715 1.000000e+00   3 146088712 146088815 104 - 0.053 0.000 -7.708
ENSG00000152952 E024 151.0212636 0.0020669703 5.118651e-02 1.825304e-01 3 146091800 146091901 102 - 2.044 1.957 -0.294
ENSG00000152952 E025 78.7310872 0.0088112997 7.819072e-02 2.411836e-01 3 146102755 146102759 5 - 1.771 1.634 -0.463
ENSG00000152952 E026 144.3252549 0.0018775722 1.018715e-02 5.892013e-02 3 146102760 146102852 93 - 2.029 1.909 -0.403
ENSG00000152952 E027 143.5760320 0.0002966061 4.095564e-02 1.571941e-01 3 146104279 146104342 64 - 2.020 1.938 -0.276
ENSG00000152952 E028 167.0463324 0.0003139330 2.010542e-01 4.310290e-01 3 146106532 146106644 113 - 2.081 2.037 -0.148
ENSG00000152952 E029 89.5463443 0.0005447333 6.269744e-01 7.885144e-01 3 146110285 146110299 15 - 1.813 1.793 -0.066
ENSG00000152952 E030 159.6999103 0.0002808627 3.234042e-01 5.627488e-01 3 146110300 146110448 149 - 2.061 2.028 -0.111
ENSG00000152952 E031 147.8307619 0.0003090249 6.167436e-01 7.815419e-01 3 146121112 146121248 137 - 2.025 2.011 -0.047
ENSG00000152952 E032 1.1176617 0.0153787590 1.000000e+00   3 146123265 146123325 61 - 0.252 0.254 0.016
ENSG00000152952 E033 108.4553818 0.0004159695 2.254685e-01 4.598986e-01 3 146124138 146124229 92 - 1.898 1.845 -0.178
ENSG00000152952 E034 3.0925227 0.2044036870 8.745989e-01 9.385019e-01 3 146160789 146160880 92 - 0.487 0.541 0.260
ENSG00000152952 E035 80.5355062 0.0004764580 2.553760e-01 4.940210e-01 3 146160881 146161184 304 - 1.754 1.820 0.225
ENSG00000152952 E036 0.0000000       3 146163594 146163653 60 -