ENSG00000152894

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368202 ENSG00000152894 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRK protein_coding processed_transcript 8.482985 4.999794 12.79677 1.246265 0.5685989 1.354084 0.2081507 0.28793875 0.08165801 0.14316169 0.08165801 -1.700683 0.04034167 0.056000000 0.005933333 -0.05006667 1.548958e-01 7.12651e-09   FALSE
ENST00000368215 ENSG00000152894 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRK protein_coding protein_coding 8.482985 4.999794 12.79677 1.246265 0.5685989 1.354084 0.9787347 0.05009596 2.52321463 0.02513302 0.21427036 5.397557 0.08000417 0.008033333 0.199400000 0.19136667 7.126510e-09 7.12651e-09 FALSE TRUE
ENST00000368226 ENSG00000152894 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRK protein_coding protein_coding 8.482985 4.999794 12.79677 1.246265 0.5685989 1.354084 5.6396081 4.29164615 8.62723005 1.22328545 0.21842097 1.005680 0.69678750 0.834433333 0.675400000 -0.15903333 1.767576e-01 7.12651e-09 FALSE TRUE
ENST00000392449 ENSG00000152894 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRK protein_coding nonsense_mediated_decay 8.482985 4.999794 12.79677 1.246265 0.5685989 1.354084 0.2987904 0.22948403 0.05934862 0.11638838 0.03082803 -1.787990 0.04316250 0.066833333 0.004600000 -0.06223333 5.809327e-01 7.12651e-09 FALSE TRUE
MSTRG.28942.6 ENSG00000152894 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPRK protein_coding   8.482985 4.999794 12.79677 1.246265 0.5685989 1.354084 0.8122036 0.02560843 0.93788001 0.02560843 0.47147157 4.734414 0.06819167 0.010200000 0.070466667 0.06026667 6.802258e-01 7.12651e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152894 E001 43.2644487 0.0023802708 3.047664e-04 0.0037781107 6 127968785 127968976 192 - 1.542 1.743 0.684
ENSG00000152894 E002 160.2805327 0.0039557393 7.534651e-06 0.0001640247 6 127968977 127969836 860 - 2.112 2.291 0.599
ENSG00000152894 E003 37.3037318 0.0012924444 2.082818e-03 0.0176194502 6 127969837 127969895 59 - 1.489 1.666 0.603
ENSG00000152894 E004 63.0203028 0.0010230420 3.552432e-03 0.0266633382 6 127969896 127970069 174 - 1.732 1.863 0.441
ENSG00000152894 E005 33.1393015 0.0011892129 2.173340e-02 0.1017006295 6 127970070 127970112 43 - 1.456 1.595 0.474
ENSG00000152894 E006 87.6676208 0.0004248377 5.257460e-06 0.0001203285 6 127970113 127970280 168 - 1.861 2.030 0.566
ENSG00000152894 E007 83.2569755 0.0016404100 6.496808e-05 0.0010421341 6 127973022 127973157 136 - 1.842 2.006 0.552
ENSG00000152894 E008 81.5998961 0.0015666877 7.377624e-01 0.8591091603 6 127973664 127973827 164 - 1.891 1.898 0.021
ENSG00000152894 E009 71.4278124 0.0074836946 4.218524e-01 0.6450605421 6 127976657 127976782 126 - 1.849 1.787 -0.210
ENSG00000152894 E010 76.2485008 0.0005219884 4.678079e-01 0.6785806229 6 127976923 127977054 132 - 1.855 1.880 0.084
ENSG00000152894 E011 78.3518272 0.0005610600 8.098160e-02 0.2467619668 6 127981116 127981289 174 - 1.851 1.918 0.227
ENSG00000152894 E012 69.9459480 0.0035866530 1.965816e-01 0.4252695256 6 127982831 127982980 150 - 1.802 1.864 0.209
ENSG00000152894 E013 63.2047039 0.0038096029 1.973923e-02 0.0950190049 6 127983242 127983377 136 - 1.737 1.858 0.409
ENSG00000152894 E014 45.8454547 0.0008614879 2.684110e-02 0.1178039928 6 127985721 127985820 100 - 1.606 1.719 0.384
ENSG00000152894 E015 43.6428983 0.0012062754 8.169806e-01 0.9064342172 6 127985821 127985875 55 - 1.621 1.629 0.030
ENSG00000152894 E016 55.1852150 0.0302309332 2.922666e-01 0.5329641115 6 127990769 127990859 91 - 1.747 1.670 -0.261
ENSG00000152894 E017 37.7432727 0.0176964337 6.896517e-02 0.2227057946 6 127990860 127990885 26 - 1.607 1.440 -0.571
ENSG00000152894 E018 61.2428179 0.0328794406 6.968721e-02 0.2241508251 6 127991294 127991391 98 - 1.812 1.653 -0.539
ENSG00000152894 E019 43.4006319 0.0071578657 2.710595e-03 0.0216275822 6 127992673 127992709 37 - 1.682 1.468 -0.731
ENSG00000152894 E020 0.0000000       6 127995249 127995266 18 -      
ENSG00000152894 E021 48.3362650 0.0079007735 1.887015e-02 0.0919907736 6 127995462 127995538 77 - 1.715 1.554 -0.547
ENSG00000152894 E022 52.9316547 0.0067903002 2.244081e-02 0.1040536935 6 127996901 127996988 88 - 1.749 1.598 -0.514
ENSG00000152894 E023 70.7758099 0.0055030552 5.506100e-02 0.1914689065 6 127998720 127998904 185 - 1.868 1.753 -0.390
ENSG00000152894 E024 0.2027342 0.0334450754 2.219568e-01   6 127999987 128000330 344 - 0.000 0.167 12.565
ENSG00000152894 E025 0.0000000       6 128001196 128001207 12 -      
ENSG00000152894 E026 0.3150090 0.0527012050 5.651330e-01   6 128003197 128003232 36 - 0.087 0.167 1.076
ENSG00000152894 E027 0.7673035 0.0172671820 1.094670e-01   6 128004977 128005083 107 - 0.325 0.000 -12.776
ENSG00000152894 E028 54.8634815 0.0007070531 3.625910e-03 0.0270784023 6 128005084 128005244 161 - 1.770 1.610 -0.543
ENSG00000152894 E029 0.0000000       6 128006026 128006055 30 -      
ENSG00000152894 E030 0.1426347 0.0328641573 1.000000e+00   6 128008046 128008087 42 - 0.087 0.000 -10.454
ENSG00000152894 E031 47.0554594 0.0214550386 8.023697e-01 0.8977166939 6 128009130 128009265 136 - 1.655 1.658 0.011
ENSG00000152894 E032 17.8144977 0.1328958297 5.962806e-01 0.7678414460 6 128009266 128009268 3 - 1.216 1.310 0.331
ENSG00000152894 E033 0.3040503 0.0244411696 5.331961e-01   6 128062066 128062424 359 - 0.160 0.000 -11.454
ENSG00000152894 E034 0.0000000       6 128063436 128063525 90 -      
ENSG00000152894 E035 24.3115633 0.1505967945 3.428511e-01 0.5805330632 6 128064758 128064794 37 - 1.327 1.465 0.476
ENSG00000152894 E036 65.3735552 0.0009680688 1.732084e-01 0.3947870260 6 128067519 128067792 274 - 1.779 1.834 0.186
ENSG00000152894 E037 48.0116558 0.0010370002 2.113376e-01 0.4433702295 6 128078813 128078918 106 - 1.687 1.610 -0.261
ENSG00000152894 E038 69.9142291 0.0105908811 7.388548e-01 0.8597164713 6 128082437 128082638 202 - 1.837 1.805 -0.106
ENSG00000152894 E039 40.9143026 0.2857685756 5.151318e-01 0.7117271773 6 128083715 128083824 110 - 1.587 1.617 0.101
ENSG00000152894 E040 92.8153332 0.0040087448 2.032504e-02 0.0970248605 6 128089690 128089992 303 - 1.988 1.861 -0.425
ENSG00000152894 E041 66.1143843 0.0007438209 1.116685e-02 0.0630706848 6 128184432 128184572 141 - 1.841 1.712 -0.437
ENSG00000152894 E042 69.3110174 0.0006679021 3.801141e-04 0.0045398496 6 128184573 128184725 153 - 1.872 1.696 -0.595
ENSG00000152894 E043 62.0348988 0.0009398409 1.639781e-04 0.0022649252 6 128218922 128219069 148 - 1.830 1.629 -0.679
ENSG00000152894 E044 28.5728283 0.0534934937 1.038944e-01 0.2886670834 6 128219070 128219096 27 - 1.505 1.305 -0.690
ENSG00000152894 E045 0.0000000       6 128230732 128230865 134 -      
ENSG00000152894 E046 0.0000000       6 128232090 128232151 62 -      
ENSG00000152894 E047 0.0000000       6 128235380 128235604 225 -      
ENSG00000152894 E048 44.8069831 0.0060406121 1.463815e-02 0.0767251019 6 128240035 128240150 116 - 1.688 1.513 -0.594
ENSG00000152894 E049 0.0000000       6 128241223 128241299 77 -      
ENSG00000152894 E050 44.6752432 0.0087654840 5.064333e-03 0.0349666706 6 128242521 128242602 82 - 1.695 1.475 -0.752
ENSG00000152894 E051 0.9806365 0.0166082221 6.822018e-02   6 128321041 128321402 362 - 0.369 0.000 -13.042
ENSG00000152894 E052 6.3970774 0.0404702464 5.140294e-04 0.0058045091 6 128321403 128322038 636 - 0.615 1.105 1.912
ENSG00000152894 E053 81.9715261 0.0108744602 1.449902e-01 0.3549111492 6 128322039 128322250 212 - 1.929 1.809 -0.403
ENSG00000152894 E054 49.3338995 0.0138849176 1.086832e-01 0.2969018415 6 128322251 128322310 60 - 1.723 1.572 -0.513
ENSG00000152894 E055 56.4284803 0.0167401113 3.853110e-01 0.6167205664 6 128397566 128397688 123 - 1.765 1.671 -0.321
ENSG00000152894 E056 0.7804750 0.0239990094 5.817288e-01   6 128409294 128409332 39 - 0.276 0.167 -0.926
ENSG00000152894 E057 0.6653672 0.4275859257 5.234948e-01   6 128491732 128491849 118 - 0.160 0.290 1.096
ENSG00000152894 E058 0.0000000       6 128491850 128491857 8 -      
ENSG00000152894 E059 2.4345076 0.0095151881 1.837422e-04 0.0024919063 6 128518928 128519141 214 - 0.222 0.820 3.071
ENSG00000152894 E060 54.9318115 0.0012391227 1.939407e-02 0.0938255696 6 128520259 128520616 358 - 1.685 1.794 0.370