ENSG00000152795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507721 ENSG00000152795 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPDL protein_coding protein_coding 179.5313 122.6582 158.5442 16.83461 2.552353 0.3702144 45.92117 25.137378 73.48408 5.688769 1.7880407 1.5472200 0.27009583 0.22606667 0.46400000 0.2379333 0.2039860762 0.0003534546 FALSE TRUE
ENST00000621267 ENSG00000152795 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPDL protein_coding protein_coding 179.5313 122.6582 158.5442 16.83461 2.552353 0.3702144 13.66752 6.386693 12.80757 1.601059 1.6392484 1.0027246 0.07516667 0.05073333 0.08053333 0.0298000 0.4788645830 0.0003534546 FALSE TRUE
ENST00000630114 ENSG00000152795 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPDL protein_coding nonsense_mediated_decay 179.5313 122.6582 158.5442 16.83461 2.552353 0.3702144 17.86030 12.987835 32.40549 6.590492 0.6220481 1.3184119 0.10331667 0.09413333 0.20440000 0.1102667 0.7932649614 0.0003534546 TRUE TRUE
ENST00000630827 ENSG00000152795 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPDL protein_coding protein_coding 179.5313 122.6582 158.5442 16.83461 2.552353 0.3702144 87.14428 62.959444 32.29309 12.914098 3.6617294 -0.9629799 0.47061667 0.50273333 0.20323333 -0.2995000 0.0003534546 0.0003534546 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152795 E001 0.00000       4 82422565 82422568 4 -      
ENSG00000152795 E002 580.85246 0.0061334351 2.032481e-01 4.336152e-01 4 82422569 82424624 2056 - 2.815 2.717 -0.326
ENSG00000152795 E003 47.43601 0.0200166292 6.073313e-01 7.751011e-01 4 82424625 82424628 4 - 1.679 1.681 0.009
ENSG00000152795 E004 46.13329 0.0201327595 4.312290e-01 6.520925e-01 4 82424629 82424629 1 - 1.654 1.679 0.084
ENSG00000152795 E005 45.31625 0.0237484801 4.928234e-01 6.958859e-01 4 82424630 82424630 1 - 1.649 1.669 0.069
ENSG00000152795 E006 847.63416 0.0049607825 2.949820e-02 1.258728e-01 4 82424631 82424883 253 - 2.899 2.940 0.136
ENSG00000152795 E007 695.32930 0.0611048878 3.276210e-02 1.353894e-01 4 82424884 82425562 679 - 2.984 2.692 -0.970
ENSG00000152795 E008 256.83746 0.0313959278 6.113325e-03 4.027713e-02 4 82425563 82425582 20 - 2.558 2.256 -1.006
ENSG00000152795 E009 412.30502 0.0288815001 1.501497e-02 7.813833e-02 4 82425583 82425667 85 - 2.743 2.486 -0.855
ENSG00000152795 E010 441.11617 0.0993768215 4.260902e-02 1.615429e-01 4 82425668 82426036 369 - 2.803 2.473 -1.099
ENSG00000152795 E011 1020.15476 0.0013484381 1.313115e-01 3.338808e-01 4 82426037 82426129 93 - 3.016 3.001 -0.051
ENSG00000152795 E012 1256.73420 0.0014151216 1.460338e-01 3.564331e-01 4 82426463 82426633 171 - 3.107 3.091 -0.051
ENSG00000152795 E013 918.51606 0.0056050516 3.530360e-01 5.900456e-01 4 82427190 82427304 115 - 2.960 2.959 -0.003
ENSG00000152795 E014 1066.31442 0.0034207045 5.193499e-01 7.146093e-01 4 82427433 82427564 132 - 3.037 3.015 -0.074
ENSG00000152795 E015 1201.58949 0.0036314509 2.287454e-01 4.637415e-01 4 82428018 82428179 162 - 3.078 3.073 -0.017
ENSG00000152795 E016 1208.30475 0.0003176231 4.729385e-07 1.475038e-05 4 82428278 82428446 169 - 3.077 3.089 0.040
ENSG00000152795 E017 779.58463 0.0011599917 5.353473e-07 1.644317e-05 4 82429248 82429412 165 - 2.858 2.916 0.193
ENSG00000152795 E018 340.25490 0.0067354551 8.987610e-05 1.366675e-03 4 82429413 82430341 929 - 2.439 2.585 0.485
ENSG00000152795 E019 9.96776 1.0786726660 1.000000e+00 1.000000e+00 4 82430342 82430568 227 - 0.836 1.133 1.104