ENSG00000152763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371022 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding protein_coding 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 0.2561332 0.34668809 0.4058177 0.12271474 0.25138264 0.2212882 0.07043750 0.08063333 0.11596667 0.03533333 1.000000000 0.001195795 FALSE TRUE
ENST00000371023 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding protein_coding 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 0.4164994 0.15710049 0.5627160 0.08001579 0.28966897 1.7771040 0.13022500 0.04120000 0.14686667 0.10566667 0.830713811 0.001195795 FALSE TRUE
ENST00000371026 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding protein_coding 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 0.1975855 0.08923931 0.2890780 0.05346276 0.07818992 1.5915383 0.06151250 0.01920000 0.07953333 0.06033333 0.351626766 0.001195795 FALSE TRUE
ENST00000474506 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding processed_transcript 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 2.2959179 3.41570785 1.7615536 0.62616706 0.21296844 -0.9513870 0.59598750 0.78416667 0.47523333 -0.30893333 0.001195795 0.001195795   FALSE
ENST00000531980 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding nonsense_mediated_decay 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 0.2334806 0.22266987 0.3204159 0.13673911 0.06580006 0.5059988 0.07185417 0.04870000 0.08526667 0.03656667 0.753681672 0.001195795   FALSE
ENST00000532629 ENSG00000152763 HEK293_OSMI2_6hA HEK293_TMG_6hB DNAI4 protein_coding nonsense_mediated_decay 3.635334 4.370081 3.705759 0.8447276 0.2005604 -0.2373003 0.1069735 0.00000000 0.2268051 0.00000000 0.13819513 4.5656284 0.03172917 0.00000000 0.06170000 0.06170000 0.283011567 0.001195795   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152763 E001 0.0000000       1 66812885 66812890 6 -      
ENSG00000152763 E002 2.1298754 0.011185032 3.662819e-01 0.600946696 1 66812891 66813969 1079 - 0.551 0.392 -0.797
ENSG00000152763 E003 1.1384679 0.015828643 4.338962e-01   1 66813970 66814180 211 - 0.383 0.239 -0.949
ENSG00000152763 E004 2.9706401 0.014670075 8.821995e-01 0.942457435 1 66822361 66822517 157 - 0.614 0.632 0.079
ENSG00000152763 E005 3.0071570 0.017083456 8.696566e-01 0.935661853 1 66826820 66827046 227 - 0.613 0.633 0.083
ENSG00000152763 E006 0.7765309 0.625082485 6.408450e-01   1 66827812 66827910 99 - 0.331 0.132 -1.690
ENSG00000152763 E007 1.9669161 0.231704691 3.698828e-01 0.603893098 1 66833585 66833706 122 - 0.557 0.320 -1.258
ENSG00000152763 E008 2.4960660 0.118866692 4.217690e-02 0.160381188 1 66833991 66834148 158 - 0.676 0.239 -2.349
ENSG00000152763 E009 1.4818116 0.012597170 1.970522e-01 0.425891569 1 66835626 66835777 152 - 0.475 0.239 -1.432
ENSG00000152763 E010 0.0000000       1 66837603 66837606 4 -      
ENSG00000152763 E011 0.4632531 0.025644948 1.390743e-01   1 66837607 66837709 103 - 0.267 0.000 -12.371
ENSG00000152763 E012 1.5275719 0.164396170 2.894308e-01 0.529946553 1 66837710 66837796 87 - 0.480 0.239 -1.460
ENSG00000152763 E013 3.8394456 0.118810065 1.968688e-01 0.425629100 1 66840469 66840671 203 - 0.785 0.505 -1.215
ENSG00000152763 E014 2.9720427 0.015983208 7.382282e-01 0.859403993 1 66847484 66847678 195 - 0.615 0.553 -0.278
ENSG00000152763 E015 0.0000000       1 66847924 66848311 388 -      
ENSG00000152763 E016 0.0000000       1 66860713 66860839 127 -      
ENSG00000152763 E017 3.2453082 0.010680903 2.464895e-01 0.484138441 1 66862147 66862272 126 - 0.696 0.506 -0.844
ENSG00000152763 E018 1.2740880 0.015378759 6.453538e-02   1 66862273 66862302 30 - 0.474 0.136 -2.430
ENSG00000152763 E019 0.0000000       1 66862303 66862304 2 -      
ENSG00000152763 E020 1.1682076 0.017831877 9.932699e-01   1 66870805 66871369 565 - 0.329 0.323 -0.042
ENSG00000152763 E021 9.3801426 0.003544954 5.230499e-01 0.717123737 1 66871370 66871509 140 - 1.049 0.975 -0.273
ENSG00000152763 E022 8.9781026 0.007020182 8.484022e-01 0.924040067 1 66874781 66874937 157 - 1.003 0.975 -0.103
ENSG00000152763 E023 0.3150090 0.027857106 8.332548e-01   1 66890183 66891153 971 - 0.108 0.136 0.376
ENSG00000152763 E024 11.5423081 0.003967486 9.762884e-02 0.277650500 1 66891154 66891266 113 - 1.027 1.174 0.533
ENSG00000152763 E025 8.2581202 0.004904587 6.843354e-01 0.825508309 1 66893229 66893276 48 - 0.991 0.939 -0.192
ENSG00000152763 E026 10.2203343 0.003613377 9.102998e-01 0.957311206 1 66893277 66893361 85 - 1.049 1.052 0.009
ENSG00000152763 E027 8.7993804 0.003991869 6.521216e-01 0.804830479 1 66893362 66893413 52 - 1.015 0.958 -0.211
ENSG00000152763 E028 0.5115862 0.021768165 4.184017e-01   1 66904859 66905200 342 - 0.108 0.239 1.372
ENSG00000152763 E029 12.8378374 0.003694166 5.804378e-01 0.757468807 1 66905201 66905375 175 - 1.165 1.105 -0.212
ENSG00000152763 E030 0.5059767 0.021833392 4.869611e-02   1 66906921 66907016 96 - 0.000 0.323 11.991
ENSG00000152763 E031 0.7860845 0.017173670 3.583029e-02   1 66919018 66919116 99 - 0.383 0.000 -12.942
ENSG00000152763 E032 6.0189893 0.007601567 7.560494e-05 0.001183469 1 66921243 66921401 159 - 0.550 1.053 2.014
ENSG00000152763 E033 23.5584834 0.001762805 1.558367e-02 0.080293236 1 66924662 66924856 195 - 1.313 1.461 0.513