ENSG00000152700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402673 ENSG00000152700 HEK293_OSMI2_6hA HEK293_TMG_6hB SAR1B protein_coding protein_coding 29.27858 10.11168 54.75719 1.994019 3.175846 2.435863 5.626467 2.597876 8.447054 0.67227064 0.2785753 1.6972799 0.2187167 0.2490333 0.15480000 -0.09423333 8.494097e-02 1.193391e-06 FALSE TRUE
ENST00000439578 ENSG00000152700 HEK293_OSMI2_6hA HEK293_TMG_6hB SAR1B protein_coding protein_coding 29.27858 10.11168 54.75719 1.994019 3.175846 2.435863 21.172840 5.157406 43.629875 1.30125102 2.9386494 3.0781347 0.6309125 0.4959667 0.79593333 0.29996667 1.193391e-06 1.193391e-06 FALSE TRUE
MSTRG.26941.3 ENSG00000152700 HEK293_OSMI2_6hA HEK293_TMG_6hB SAR1B protein_coding   29.27858 10.11168 54.75719 1.994019 3.175846 2.435863 1.734272 1.634943 1.762757 0.01814763 0.2342929 0.1079577 0.1012000 0.1799333 0.03253333 -0.14740000 4.685763e-04 1.193391e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152700 E001 552.6709903 0.0034823817 8.844735e-16 1.496055e-13 5 134601149 134606428 5280 - 2.567 2.848 0.933
ENSG00000152700 E002 23.5619898 0.0611088780 5.989972e-01 7.695684e-01 5 134606429 134606429 1 - 1.260 1.368 0.379
ENSG00000152700 E003 155.5805668 0.0005329459 1.727017e-01 3.940610e-01 5 134606430 134606737 308 - 2.067 2.163 0.323
ENSG00000152700 E004 95.1397145 0.0004790815 5.284708e-01 7.209596e-01 5 134606738 134606801 64 - 1.873 1.894 0.070
ENSG00000152700 E005 216.4316137 0.0003480165 1.584572e-02 8.122942e-02 5 134606802 134606948 147 - 2.236 2.211 -0.084
ENSG00000152700 E006 167.7820888 0.0010679097 2.500885e-04 3.220655e-03 5 134606949 134606986 38 - 2.138 2.045 -0.310
ENSG00000152700 E007 139.5585826 0.0004672986 1.526962e-03 1.380048e-02 5 134606987 134606989 3 - 2.056 1.979 -0.255
ENSG00000152700 E008 182.0280383 0.0013701800 4.321435e-03 3.094821e-02 5 134606990 134607036 47 - 2.168 2.111 -0.194
ENSG00000152700 E009 176.1623680 0.0003778401 2.082692e-04 2.764707e-03 5 134607037 134607066 30 - 2.158 2.078 -0.268
ENSG00000152700 E010 295.6550432 0.0001975704 1.163128e-03 1.114769e-02 5 134608372 134608503 132 - 2.372 2.338 -0.116
ENSG00000152700 E011 0.0000000       5 134608976 134609133 158 -      
ENSG00000152700 E012 202.6033514 0.0002236538 2.727382e-04 3.456250e-03 5 134609571 134609609 39 - 2.214 2.147 -0.225
ENSG00000152700 E013 216.4224400 0.0003238280 8.277461e-05 1.278028e-03 5 134609610 134609674 65 - 2.242 2.167 -0.250
ENSG00000152700 E014 234.2164979 0.0004240181 1.671635e-04 2.301740e-03 5 134612691 134612756 66 - 2.275 2.209 -0.219
ENSG00000152700 E015 3.3964079 0.0987143250 4.462761e-04 5.187757e-03 5 134612757 134613009 253 - 0.318 0.999 3.056
ENSG00000152700 E016 1.0233601 0.0159548804 1.086027e-01   5 134613010 134613013 4 - 0.164 0.483 2.146
ENSG00000152700 E017 1.6236384 0.0119754956 1.564195e-01 3.715089e-01 5 134613014 134613075 62 - 0.283 0.570 1.564
ENSG00000152700 E018 10.8148763 0.0729165756 1.894140e-03 1.636574e-02 5 134613076 134614903 1828 - 0.816 1.342 1.917
ENSG00000152700 E019 0.1614157 0.0332339263 1.000000e+00   5 134618192 134618313 122 - 0.062 0.000 -7.964
ENSG00000152700 E020 205.1132149 0.0002668258 5.092133e-04 5.762771e-03 5 134620933 134621001 69 - 2.218 2.157 -0.205
ENSG00000152700 E021 134.6236456 0.0003037336 9.225822e-03 5.482473e-02 5 134621002 134621052 51 - 2.035 1.983 -0.177
ENSG00000152700 E022 144.2583781 0.0005974346 4.190929e-02 1.596993e-01 5 134623962 134624037 76 - 2.063 2.034 -0.098
ENSG00000152700 E023 0.0000000       5 134625777 134625876 100 -      
ENSG00000152700 E024 3.7648367 0.0076605890 1.986876e-02 9.541262e-02 5 134631602 134632076 475 - 0.498 0.891 1.661
ENSG00000152700 E025 16.7013411 0.0061045462 7.007078e-07 2.086556e-05 5 134632077 134632195 119 - 1.002 1.499 1.757
ENSG00000152700 E026 0.5173834 0.0496319997 6.262022e-01   5 134632196 134632199 4 - 0.165 0.000 -9.554
ENSG00000152700 E027 106.1892295 0.0005266156 8.865924e-01 9.448977e-01 5 134632728 134632828 101 - 1.916 1.970 0.182
ENSG00000152700 E028 38.0721106 0.1017814483 8.991347e-09 4.272349e-07 5 134648116 134649271 1156 - 1.052 2.059 3.466