ENSG00000152620

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282512 ENSG00000152620 HEK293_OSMI2_6hA HEK293_TMG_6hB NADK2 protein_coding protein_coding 12.27208 5.359265 20.84162 0.546206 0.6914061 1.957363 3.094328 0.9781734 7.2342729 0.04603133 0.2506571 2.874005 0.20981667 0.1859667 0.34740000 0.16143333 0.004987106 0.004987106 FALSE TRUE
ENST00000381937 ENSG00000152620 HEK293_OSMI2_6hA HEK293_TMG_6hB NADK2 protein_coding protein_coding 12.27208 5.359265 20.84162 0.546206 0.6914061 1.957363 1.284635 0.9340584 0.4487105 0.49338687 0.4487105 -1.041292 0.13876667 0.1593333 0.02186667 -0.13746667 0.548329578 0.004987106 FALSE TRUE
ENST00000511613 ENSG00000152620 HEK293_OSMI2_6hA HEK293_TMG_6hB NADK2 protein_coding processed_transcript 12.27208 5.359265 20.84162 0.546206 0.6914061 1.957363 2.634174 1.5180177 4.2818937 0.26440941 0.4347498 1.489953 0.20180833 0.2810000 0.20480000 -0.07620000 0.473649799 0.004987106   FALSE
ENST00000514504 ENSG00000152620 HEK293_OSMI2_6hA HEK293_TMG_6hB NADK2 protein_coding protein_coding 12.27208 5.359265 20.84162 0.546206 0.6914061 1.957363 1.768178 0.2663951 3.7919004 0.26639510 0.3394541 3.781917 0.09583333 0.0622000 0.18236667 0.12016667 0.326716809 0.004987106 FALSE TRUE
MSTRG.26068.3 ENSG00000152620 HEK293_OSMI2_6hA HEK293_TMG_6hB NADK2 protein_coding   12.27208 5.359265 20.84162 0.546206 0.6914061 1.957363 2.484745 1.4459908 4.0438279 0.10801488 0.5188764 1.477284 0.25747083 0.2720000 0.19393333 -0.07806667 0.485165351 0.004987106 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152620 E001 0.0000000       5 36192589 36192591 3 -      
ENSG00000152620 E002 0.2852693 0.2294606732 0.702761900   5 36192592 36192884 293 - 0.137 0.000 -10.776
ENSG00000152620 E003 83.7514618 0.0209512682 0.019297806 0.09350104 5 36192885 36193712 828 - 1.790 2.042 0.847
ENSG00000152620 E004 178.5820543 0.0082667991 0.621786976 0.78501345 5 36193713 36194821 1109 - 2.186 2.224 0.127
ENSG00000152620 E005 77.1902305 0.0206555495 0.191250176 0.41843634 5 36194822 36194985 164 - 1.797 1.937 0.473
ENSG00000152620 E006 31.7626268 0.1580288385 0.178259480 0.40155674 5 36194986 36194987 2 - 1.384 1.627 0.836
ENSG00000152620 E007 58.3931631 0.3291540217 0.225643465 0.46009964 5 36194988 36195061 74 - 1.639 1.886 0.835
ENSG00000152620 E008 64.1179956 0.9070927621 0.417166322 0.64152886 5 36195062 36195143 82 - 1.695 1.897 0.682
ENSG00000152620 E009 87.8616223 1.2573748493 0.449297963 0.66523654 5 36195144 36195282 139 - 1.820 2.049 0.770
ENSG00000152620 E010 78.0077160 0.0453544546 0.184838085 0.41027567 5 36197541 36197664 124 - 1.794 1.955 0.545
ENSG00000152620 E011 64.3564871 0.0025734615 0.861421582 0.93114540 5 36200227 36200280 54 - 1.748 1.792 0.151
ENSG00000152620 E012 68.0840171 0.0082417367 0.465164970 0.67667235 5 36201106 36201161 56 - 1.781 1.794 0.043
ENSG00000152620 E013 79.9549642 0.0157156096 0.080525583 0.24590631 5 36207170 36207265 96 - 1.868 1.803 -0.220
ENSG00000152620 E014 2.3446340 0.0101904317 0.499380603 0.70039253 5 36208625 36208690 66 - 0.512 0.425 -0.437
ENSG00000152620 E015 74.5269413 0.0143800335 0.019117581 0.09286458 5 36211844 36211922 79 - 1.846 1.734 -0.375
ENSG00000152620 E016 0.0000000       5 36212264 36212313 50 -      
ENSG00000152620 E017 0.8192208 0.2368587759 0.202052965   5 36213013 36213177 165 - 0.289 0.000 -12.119
ENSG00000152620 E018 61.2887771 0.0008108368 0.025157290 0.11269253 5 36217748 36217793 46 - 1.753 1.692 -0.206
ENSG00000152620 E019 85.2407981 0.0072872785 0.236803290 0.47290203 5 36217794 36217884 91 - 1.880 1.870 -0.034
ENSG00000152620 E020 0.7860845 0.0168634125 0.149618916   5 36217885 36218257 373 - 0.288 0.000 -12.109
ENSG00000152620 E021 76.7200733 0.0129442453 0.442117066 0.66015129 5 36219596 36219679 84 - 1.832 1.838 0.022
ENSG00000152620 E022 79.1273038 0.0121608226 0.013140970 0.07101928 5 36225542 36225623 82 - 1.873 1.762 -0.376
ENSG00000152620 E023 74.8177679 0.0028260296 0.003692799 0.02743797 5 36226475 36226563 89 - 1.846 1.751 -0.321
ENSG00000152620 E024 52.1989800 0.0061593978 0.006241464 0.04091435 5 36227477 36227565 89 - 1.699 1.574 -0.425
ENSG00000152620 E025 0.1779838 0.0503432712 1.000000000   5 36241359 36241498 140 - 0.075 0.000 -9.790
ENSG00000152620 E026 29.1216815 0.0209273259 0.934707578 0.96958622 5 36241499 36241925 427 - 1.406 1.459 0.183
ENSG00000152620 E027 3.4332749 0.1374702850 0.682204492 0.82409205 5 36241963 36242095 133 - 0.624 0.567 -0.254
ENSG00000152620 E028 4.3622998 0.0664091655 0.526304857 0.71940240 5 36242096 36242279 184 - 0.698 0.632 -0.278