ENSG00000152601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324210 ENSG00000152601 HEK293_OSMI2_6hA HEK293_TMG_6hB MBNL1 protein_coding protein_coding 11.02515 3.480359 22.00954 0.9526985 1.111741 2.657337 3.04015802 0.5252373 6.473868 0.1356327 0.3358805 3.598604 0.21645000 0.1574667 0.29426667 0.1368000 0.02095305 0.02095305 FALSE TRUE
ENST00000463374 ENSG00000152601 HEK293_OSMI2_6hA HEK293_TMG_6hB MBNL1 protein_coding protein_coding 11.02515 3.480359 22.00954 0.9526985 1.111741 2.657337 0.69718503 0.4637967 2.166479 0.2675932 0.1997965 2.199656 0.09437500 0.1649333 0.09843333 -0.0665000 1.00000000 0.02095305 FALSE TRUE
ENST00000478535 ENSG00000152601 HEK293_OSMI2_6hA HEK293_TMG_6hB MBNL1 protein_coding protein_coding 11.02515 3.480359 22.00954 0.9526985 1.111741 2.657337 0.74149161 0.9225547 0.000000 0.5595380 0.0000000 -6.543116 0.22079167 0.2117667 0.00000000 -0.2117667 0.06181857 0.02095305 FALSE TRUE
MSTRG.23937.11 ENSG00000152601 HEK293_OSMI2_6hA HEK293_TMG_6hB MBNL1 protein_coding   11.02515 3.480359 22.00954 0.9526985 1.111741 2.657337 4.47876169 0.9721192 9.049556 0.4876827 0.5576292 3.205470 0.28015417 0.2202333 0.41363333 0.1934000 0.71033473 0.02095305 FALSE TRUE
MSTRG.23937.12 ENSG00000152601 HEK293_OSMI2_6hA HEK293_TMG_6hB MBNL1 protein_coding   11.02515 3.480359 22.00954 0.9526985 1.111741 2.657337 0.04394739 0.2031800 0.000000 0.2031800 0.0000000 -4.414000 0.02297917 0.1282000 0.00000000 -0.1282000 0.73028609 0.02095305 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152601 E001 0.0000000       3 152243828 152244040 213 +      
ENSG00000152601 E002 0.0000000       3 152244321 152244440 120 +      
ENSG00000152601 E003 0.1426347 0.0337547091 1.000000e+00   3 152268040 152268467 428 + 0.049 0.001 -6.414
ENSG00000152601 E004 1.9964887 0.1424807882 8.805647e-01 9.415522e-01 3 152268468 152268905 438 + 0.362 0.436 0.414
ENSG00000152601 E005 2.7246865 0.3759520921 4.760104e-01 6.842524e-01 3 152268906 152268919 14 + 0.475 0.266 -1.233
ENSG00000152601 E006 3.3140061 0.4610465730 4.156522e-01 6.402941e-01 3 152268920 152268928 9 + 0.536 0.265 -1.531
ENSG00000152601 E007 4.9013719 0.4839795490 8.220770e-01 9.091464e-01 3 152268929 152268946 18 + 0.641 0.550 -0.407
ENSG00000152601 E008 19.9317136 0.5950553609 9.327792e-01 9.685126e-01 3 152268947 152269092 146 + 1.154 1.148 -0.019
ENSG00000152601 E009 1.6406545 0.0167445348 1.687268e-01 3.888976e-01 3 152269103 152269407 305 + 0.343 0.000 -11.567
ENSG00000152601 E010 0.4466850 0.0243227754 1.000000e+00   3 152269449 152269778 330 + 0.134 0.000 -9.830
ENSG00000152601 E011 1.8368540 0.0677080404 3.689516e-02 1.466678e-01 3 152298966 152298981 16 + 0.264 0.724 2.361
ENSG00000152601 E012 31.7707237 0.0053085166 4.172759e-01 6.415964e-01 3 152298982 152299254 273 + 1.343 1.354 0.036
ENSG00000152601 E013 96.6989722 0.0043838004 1.282917e-02 6.974703e-02 3 152299405 152299682 278 + 1.822 1.751 -0.241
ENSG00000152601 E014 199.9125594 0.0003727016 2.620635e-11 2.098275e-09 3 152299683 152300193 511 + 2.143 1.967 -0.589
ENSG00000152601 E015 46.2282129 0.0007945545 5.534381e-04 6.161030e-03 3 152300194 152300197 4 + 1.520 1.320 -0.691
ENSG00000152601 E016 97.3332105 0.0006648364 6.133337e-04 6.697413e-03 3 152300198 152300367 170 + 1.829 1.730 -0.333
ENSG00000152601 E017 3.5241308 0.0135338339 7.214291e-01 8.490492e-01 3 152301919 152302449 531 + 0.516 0.649 0.600
ENSG00000152601 E018 0.0000000       3 152335111 152335230 120 +      
ENSG00000152601 E019 0.0000000       3 152396167 152396224 58 +      
ENSG00000152601 E020 76.0251246 0.0005437101 4.342715e-02 1.636582e-01 3 152414941 152415057 117 + 1.717 1.686 -0.104
ENSG00000152601 E021 45.7277985 0.0119239045 2.095396e-01 4.413424e-01 3 152415058 152415111 54 + 1.500 1.490 -0.037
ENSG00000152601 E022 89.1705427 0.0006017265 8.235180e-03 5.040631e-02 3 152432717 152432920 204 + 1.789 1.730 -0.197
ENSG00000152601 E023 97.3406092 0.0005127460 8.639438e-02 2.572162e-01 3 152445282 152445539 258 + 1.818 1.819 0.001
ENSG00000152601 E024 34.9846260 0.0023995961 4.234045e-01 6.461813e-01 3 152446704 152446757 54 + 1.382 1.401 0.067
ENSG00000152601 E025 58.2593955 0.0006258666 3.220069e-01 5.614509e-01 3 152447620 152447724 105 + 1.596 1.620 0.079
ENSG00000152601 E026 46.6288438 0.0007630202 3.190886e-01 5.588007e-01 3 152447725 152447773 49 + 1.504 1.519 0.050
ENSG00000152601 E027 38.8837397 0.0010192073 1.136777e-01 3.052815e-01 3 152455542 152455577 36 + 1.431 1.387 -0.154
ENSG00000152601 E028 62.6222152 0.0009692814 1.047059e-01 2.901296e-01 3 152456267 152456361 95 + 1.630 1.611 -0.065
ENSG00000152601 E029 2.6822296 0.6670318342 4.039027e-01 6.314332e-01 3 152457691 152458129 439 + 0.383 0.729 1.623
ENSG00000152601 E030 0.3228314 0.4414770261 1.000000e+00   3 152458130 152458193 64 + 0.094 0.000 -8.204
ENSG00000152601 E031 9.3676898 0.0048708047 8.292832e-01 9.133950e-01 3 152458194 152459270 1077 + 0.839 0.944 0.403
ENSG00000152601 E032 72.5925103 0.0010035631 4.823214e-02 1.755487e-01 3 152459271 152459345 75 + 1.695 1.662 -0.113
ENSG00000152601 E033 923.0057271 0.0046806548 5.453336e-13 5.876281e-11 3 152462385 152465780 3396 + 2.750 2.978 0.758