ENSG00000152582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282469 ENSG00000152582 HEK293_OSMI2_6hA HEK293_TMG_6hB SPEF2 protein_coding protein_coding 1.245963 0.5598175 2.445255 0.04711569 0.4494694 2.107301 0.1657237 0.08867168 0.25238215 0.02112747 0.03938195 1.4109616 0.15231667 0.1543000 0.11480000 -0.03950000 0.820152265 0.002958784 FALSE TRUE
ENST00000502454 ENSG00000152582 HEK293_OSMI2_6hA HEK293_TMG_6hB SPEF2 protein_coding retained_intron 1.245963 0.5598175 2.445255 0.04711569 0.4494694 2.107301 0.1320303 0.09865905 0.07377035 0.05467337 0.07377035 -0.3752966 0.08646667 0.1657000 0.02323333 -0.14246667 0.470477795 0.002958784   FALSE
ENST00000505088 ENSG00000152582 HEK293_OSMI2_6hA HEK293_TMG_6hB SPEF2 protein_coding retained_intron 1.245963 0.5598175 2.445255 0.04711569 0.4494694 2.107301 0.1344784 0.00000000 0.59364286 0.00000000 0.03894053 5.9156233 0.05282500 0.0000000 0.26210000 0.26210000 0.002958784 0.002958784 FALSE TRUE
ENST00000505847 ENSG00000152582 HEK293_OSMI2_6hA HEK293_TMG_6hB SPEF2 protein_coding processed_transcript 1.245963 0.5598175 2.445255 0.04711569 0.4494694 2.107301 0.2659659 0.13001119 0.61278033 0.03592632 0.36625934 2.1531813 0.16004167 0.2473000 0.20813333 -0.03916667 0.935877834 0.002958784 FALSE TRUE
ENST00000509059 ENSG00000152582 HEK293_OSMI2_6hA HEK293_TMG_6hB SPEF2 protein_coding protein_coding 1.245963 0.5598175 2.445255 0.04711569 0.4494694 2.107301 0.4419947 0.22009649 0.82638440 0.04647738 0.09969981 1.8619272 0.43755000 0.3889667 0.35026667 -0.03870000 0.957683896 0.002958784 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152582 E001 0.1614157 0.036434549 1.00000000   5 35617844 35617862 19 + 0.072 0.000 -10.457
ENSG00000152582 E002 1.1314534 0.014781769 0.54523394   5 35617863 35617888 26 + 0.317 0.199 -0.886
ENSG00000152582 E003 1.1314534 0.014781769 0.54523394   5 35617889 35617900 12 + 0.317 0.199 -0.886
ENSG00000152582 E004 2.0523502 0.073631802 0.53703097 0.72703186 5 35617901 35617919 19 + 0.470 0.336 -0.739
ENSG00000152582 E005 4.6722698 0.006184221 0.18435866 0.40965561 5 35617920 35617997 78 + 0.739 0.522 -0.947
ENSG00000152582 E006 5.7672063 0.005144865 0.14141245 0.34961547 5 35617998 35618055 58 + 0.817 0.591 -0.936
ENSG00000152582 E007 6.8001200 0.004493644 0.26448503 0.50370234 5 35628460 35628562 103 + 0.862 0.705 -0.625
ENSG00000152582 E008 10.7182945 0.009847719 0.01956379 0.09441803 5 35641431 35641683 253 + 1.063 0.752 -1.182
ENSG00000152582 E009 0.7860845 0.017867497 0.21378486   5 35641684 35641755 72 + 0.278 0.000 -14.196
ENSG00000152582 E010 2.5633162 0.012247494 0.49826602 0.69963607 5 35643505 35643652 148 + 0.473 0.592 0.561
ENSG00000152582 E011 7.8988621 0.004849483 0.36031333 0.59594735 5 35644355 35644525 171 + 0.912 0.794 -0.456
ENSG00000152582 E012 0.7852767 0.016851852 0.42707535   5 35646531 35646666 136 + 0.187 0.335 1.110
ENSG00000152582 E013 7.4393654 0.004283736 0.74548990 0.86399564 5 35646667 35646807 141 + 0.872 0.833 -0.151
ENSG00000152582 E014 5.0665508 0.006780435 0.04480909 0.16715610 5 35649361 35649425 65 + 0.780 0.438 -1.527
ENSG00000152582 E015 8.5435411 0.024496287 0.96671666 0.98527066 5 35654540 35654641 102 + 0.914 0.903 -0.042
ENSG00000152582 E016 5.6116332 0.038243419 0.74589804 0.86428663 5 35654642 35654659 18 + 0.768 0.707 -0.248
ENSG00000152582 E017 6.6232268 0.026313254 0.57990881 0.75714206 5 35654660 35654726 67 + 0.794 0.870 0.294
ENSG00000152582 E018 4.9490785 0.006819935 0.03927764 0.15293120 5 35659019 35659049 31 + 0.644 0.931 1.143
ENSG00000152582 E019 7.3718056 0.209226760 0.75661952 0.87058127 5 35659050 35659207 158 + 0.821 1.001 0.683
ENSG00000152582 E020 9.8822066 0.003641270 0.07351999 0.23181727 5 35667072 35667259 188 + 0.922 1.120 0.727
ENSG00000152582 E021 9.8849333 0.003369068 0.34009010 0.57801941 5 35670059 35670227 169 + 0.949 1.059 0.405
ENSG00000152582 E022 4.0780081 0.009975946 0.22670853 0.46140772 5 35670228 35671575 1348 + 0.607 0.794 0.778
ENSG00000152582 E023 0.0000000       5 35675602 35675992 391 +      
ENSG00000152582 E024 6.7708755 0.004541871 0.22663182 0.46133684 5 35691037 35691256 220 + 0.872 0.704 -0.668
ENSG00000152582 E025 5.5013357 0.039396882 0.40231810 0.63024405 5 35692570 35692724 155 + 0.790 0.652 -0.568
ENSG00000152582 E026 4.2458411 0.015430806 0.84459283 0.92192227 5 35694288 35694348 61 + 0.678 0.651 -0.112
ENSG00000152582 E027 0.6847684 0.019170658 1.00000000   5 35694349 35694363 15 + 0.187 0.199 0.113
ENSG00000152582 E028 3.0714063 0.008685098 0.39461125 0.62401939 5 35695735 35695796 62 + 0.588 0.438 -0.721
ENSG00000152582 E029 2.2687536 0.014149013 0.83245070 0.91519385 5 35697690 35697793 104 + 0.473 0.438 -0.182
ENSG00000152582 E030 1.2293187 0.515369754 0.33201345   5 35697794 35700495 2702 + 0.367 0.000 -14.592
ENSG00000152582 E031 3.3676839 0.044242835 0.39366551 0.62326159 5 35700496 35700622 127 + 0.548 0.701 0.670
ENSG00000152582 E032 3.0180609 0.011147830 0.45556430 0.66994541 5 35700623 35700752 130 + 0.523 0.651 0.577
ENSG00000152582 E033 0.0000000       5 35702153 35702319 167 +      
ENSG00000152582 E034 2.6882150 0.008831177 0.60006003 0.77024814 5 35704554 35704662 109 + 0.498 0.591 0.432
ENSG00000152582 E035 1.6699463 0.014851509 0.07606524 0.23688473 5 35705651 35705791 141 + 0.278 0.592 1.697
ENSG00000152582 E036 0.7310763 0.127549017 0.26810608   5 35705792 35705808 17 + 0.134 0.338 1.701
ENSG00000152582 E037 3.0827248 0.007513555 0.44154761 0.65977088 5 35708948 35709121 174 + 0.522 0.652 0.581
ENSG00000152582 E038 17.0431822 0.020020958 0.64240561 0.79846952 5 35709122 35710850 1729 + 1.183 1.233 0.177
ENSG00000152582 E039 0.0000000       5 35712812 35712886 75 +      
ENSG00000152582 E040 0.1614157 0.036434549 1.00000000   5 35727675 35727823 149 + 0.072 0.000 -12.222
ENSG00000152582 E041 0.1723744 0.032914808 0.13918014   5 35739919 35740046 128 + 0.000 0.199 14.716
ENSG00000152582 E042 0.4952057 0.322101694 0.70121848   5 35740129 35740267 139 + 0.133 0.200 0.703
ENSG00000152582 E043 0.1614157 0.036434549 1.00000000   5 35753624 35753761 138 + 0.072 0.000 -12.222
ENSG00000152582 E044 0.3641499 0.033913420 0.39109624   5 35759568 35759719 152 + 0.072 0.199 1.699
ENSG00000152582 E045 0.2027342 0.048003702 0.13951786   5 35763522 35763702 181 + 0.000 0.199 14.701
ENSG00000152582 E046 0.0000000       5 35771609 35771735 127 +      
ENSG00000152582 E047 0.0000000       5 35771736 35771756 21 +      
ENSG00000152582 E048 0.0000000       5 35773893 35773991 99 +      
ENSG00000152582 E049 0.0000000       5 35773992 35774021 30 +      
ENSG00000152582 E050 0.0000000       5 35776257 35776395 139 +      
ENSG00000152582 E051 0.0000000       5 35779117 35779167 51 +      
ENSG00000152582 E052 0.4820342 0.021545324 0.47778965   5 35779168 35779346 179 + 0.187 0.000 -13.593
ENSG00000152582 E053 0.0000000       5 35781320 35781668 349 +      
ENSG00000152582 E054 0.0000000       5 35787866 35788100 235 +      
ENSG00000152582 E055 0.0000000       5 35788101 35788884 784 +      
ENSG00000152582 E056 0.3206185 0.027442404 0.81232702   5 35788885 35789031 147 + 0.133 0.000 -13.099
ENSG00000152582 E057 0.1426347 0.032779035 1.00000000   5 35789158 35789375 218 + 0.072 0.000 -12.220
ENSG00000152582 E058 0.0000000       5 35789497 35789705 209 +      
ENSG00000152582 E059 0.0000000       5 35789801 35789924 124 +      
ENSG00000152582 E060 0.0000000       5 35790025 35790209 185 +      
ENSG00000152582 E061 0.0000000       5 35790210 35790450 241 +      
ENSG00000152582 E062 0.0000000       5 35790451 35791056 606 +      
ENSG00000152582 E063 0.0000000       5 35791508 35791575 68 +      
ENSG00000152582 E064 0.1614157 0.036434549 1.00000000   5 35792340 35792446 107 + 0.072 0.000 -12.222
ENSG00000152582 E065 0.1779838 0.032726822 1.00000000   5 35793159 35793341 183 + 0.072 0.000 -12.222
ENSG00000152582 E066 0.1614157 0.036434549 1.00000000   5 35795703 35795795 93 + 0.072 0.000 -12.222
ENSG00000152582 E067 0.6787990 0.041266648 0.31842036   5 35799968 35800147 180 + 0.235 0.000 -13.940
ENSG00000152582 E068 0.6316833 0.033312485 1.00000000   5 35806707 35806952 246 + 0.187 0.198 0.105
ENSG00000152582 E069 0.2027342 0.048003702 0.13951786   5 35807131 35807253 123 + 0.000 0.199 14.701
ENSG00000152582 E070 0.0000000       5 35807639 35808238 600 +      
ENSG00000152582 E071 0.2027342 0.048003702 0.13951786   5 35814464 35814532 69 + 0.000 0.199 14.701
ENSG00000152582 E072 0.2027342 0.048003702 0.13951786   5 35814533 35814611 79 + 0.000 0.199 14.701