ENSG00000152520

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380958 ENSG00000152520 HEK293_OSMI2_6hA HEK293_TMG_6hB PAN3 protein_coding protein_coding 5.860594 2.841926 9.97778 0.7727109 0.3452641 1.808228 0.9869317 0.46986260 1.5007424 0.21178897 0.21760742 1.6545644 0.15531250 0.1379667 0.14973333 0.01176667 0.97785085 0.04430469 FALSE  
ENST00000399613 ENSG00000152520 HEK293_OSMI2_6hA HEK293_TMG_6hB PAN3 protein_coding protein_coding 5.860594 2.841926 9.97778 0.7727109 0.3452641 1.808228 3.8135554 1.91340984 6.8653294 0.51084678 0.16242528 1.8377626 0.67175000 0.6779000 0.68886667 0.01096667 0.98719863 0.04430469 FALSE  
ENST00000503791 ENSG00000152520 HEK293_OSMI2_6hA HEK293_TMG_6hB PAN3 protein_coding retained_intron 5.860594 2.841926 9.97778 0.7727109 0.3452641 1.808228 0.2827102 0.02233684 0.5827421 0.02233684 0.05924385 4.1961540 0.03319583 0.0063000 0.05826667 0.05196667 0.04430469 0.04430469 FALSE  
MSTRG.8530.3 ENSG00000152520 HEK293_OSMI2_6hA HEK293_TMG_6hB PAN3 protein_coding   5.860594 2.841926 9.97778 0.7727109 0.3452641 1.808228 0.3600540 0.35798189 0.6297508 0.11005828 0.14193984 0.7978754 0.07117917 0.1561333 0.06233333 -0.09380000 0.64025478 0.04430469 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152520 E001 0.9984922 0.2062789623 5.170454e-01   13 28138506 28138544 39 + 0.217 0.453 1.504
ENSG00000152520 E002 1.9673622 0.2184465556 9.896865e-01 0.9965641368 13 28138545 28138642 98 + 0.394 0.535 0.714
ENSG00000152520 E003 13.8684068 0.0029878579 5.354671e-01 0.7259207241 13 28138643 28139032 390 + 1.048 1.243 0.698
ENSG00000152520 E004 12.9898452 0.0119203407 8.618497e-01 0.9313149361 13 28139033 28139087 55 + 1.034 1.191 0.568
ENSG00000152520 E005 28.5578264 0.0051785363 3.738945e-02 0.1479814672 13 28174272 28174393 122 + 1.396 1.365 -0.110
ENSG00000152520 E006 28.2784970 0.0099994975 8.651237e-03 0.0522653537 13 28176493 28176559 67 + 1.405 1.312 -0.321
ENSG00000152520 E007 36.2406536 0.0474378058 2.749249e-03 0.0218661367 13 28177865 28177935 71 + 1.525 1.313 -0.730
ENSG00000152520 E008 16.7745751 0.0256895258 1.945959e-01 0.4228319680 13 28197185 28197346 162 + 1.166 1.139 -0.095
ENSG00000152520 E009 43.9858800 0.0023253804 8.831767e-06 0.0001884691 13 28220231 28220378 148 + 1.597 1.432 -0.565
ENSG00000152520 E010 0.1614157 0.0337969459 1.000000e+00   13 28239557 28239578 22 + 0.066 0.000 -8.729
ENSG00000152520 E011 2.1876601 0.0710958268 2.875912e-01 0.5283269237 13 28239579 28239696 118 + 0.473 0.354 -0.647
ENSG00000152520 E012 0.3040503 0.0244411696 7.282216e-01   13 28239697 28240037 341 + 0.123 0.000 -9.728
ENSG00000152520 E013 56.4525131 0.0266646996 5.014965e-02 0.1800466122 13 28256292 28256539 248 + 1.677 1.646 -0.104
ENSG00000152520 E014 32.2784961 0.0404730600 8.668308e-02 0.2576673853 13 28260447 28260551 105 + 1.443 1.393 -0.174
ENSG00000152520 E015 22.8684308 0.0614321111 3.926271e-01 0.6225163408 13 28261401 28261458 58 + 1.287 1.295 0.027
ENSG00000152520 E016 11.5701874 0.0600358933 2.753803e-01 0.5154234598 13 28266715 28266717 3 + 1.024 0.992 -0.120
ENSG00000152520 E017 42.6302011 0.0329365672 1.174115e-01 0.3115067905 13 28266718 28266876 159 + 1.556 1.527 -0.098
ENSG00000152520 E018 35.5959079 0.0326160249 1.484252e-01 0.3600315311 13 28267095 28267211 117 + 1.480 1.473 -0.027
ENSG00000152520 E019 32.5070597 0.0494965516 8.765639e-02 0.2593663186 13 28267300 28267401 102 + 1.449 1.395 -0.189
ENSG00000152520 E020 44.1137299 0.0515400198 2.121924e-01 0.4443299420 13 28270701 28270866 166 + 1.563 1.583 0.067
ENSG00000152520 E021 37.3552609 0.0117367102 1.136167e-01 0.3051780732 13 28271981 28272071 91 + 1.496 1.519 0.080
ENSG00000152520 E022 2.8590687 0.0081892065 1.968560e-03 0.0168577845 13 28272072 28272313 242 + 0.597 0.000 -12.899
ENSG00000152520 E023 50.8086258 0.0220293351 3.779292e-02 0.1490627358 13 28277237 28277376 140 + 1.635 1.591 -0.151
ENSG00000152520 E024 58.3145509 0.0373264518 1.829829e-01 0.4078151773 13 28280412 28280541 130 + 1.686 1.683 -0.008
ENSG00000152520 E025 45.1129567 0.0290520314 1.657167e-01 0.3847553289 13 28281315 28281379 65 + 1.575 1.585 0.035
ENSG00000152520 E026 53.0108060 0.0007321649 9.523280e-01 0.9781388087 13 28287984 28288122 139 + 1.616 1.760 0.487
ENSG00000152520 E027 53.9198958 0.7958466192 2.917005e-01 0.5323573586 13 28292382 28292660 279 + 1.553 1.900 1.175
ENSG00000152520 E028 23.5354503 0.5269906742 3.178937e-01 0.5578529615 13 28292661 28292768 108 + 1.221 1.527 1.063
ENSG00000152520 E029 121.6074191 1.3672472608 4.975752e-01 0.6992146608 13 28292769 28293862 1094 + 1.927 2.200 0.915
ENSG00000152520 E030 189.3918003 1.4718133791 2.879518e-01 0.5287319954 13 28293863 28295335 1473 + 2.039 2.515 1.591