ENSG00000152484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282344 ENSG00000152484 HEK293_OSMI2_6hA HEK293_TMG_6hB USP12 protein_coding protein_coding 6.964316 3.043252 11.75139 0.6844029 0.6037475 1.945639 6.3882580 2.5563562 11.4523576 0.5030711 0.51890349 2.1591105 0.8712042 0.8563 0.97516667 0.1188667 0.007941534 0.007941534 FALSE TRUE
ENST00000620323 ENSG00000152484 HEK293_OSMI2_6hA HEK293_TMG_6hB USP12 protein_coding protein_coding 6.964316 3.043252 11.75139 0.6844029 0.6037475 1.945639 0.5479119 0.4868961 0.2990284 0.1897675 0.08867097 -0.6852045 0.1234125 0.1437 0.02483333 -0.1188667 0.008323642 0.007941534   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152484 E001 399.663770 1.8401296488 0.3447104205 0.582241827 13 27066156 27069384 3229 - 2.377 2.768 1.301
ENSG00000152484 E002 47.757061 0.0008847494 0.0244608777 0.110535101 13 27071071 27071149 79 - 1.555 1.601 0.157
ENSG00000152484 E003 78.582922 0.0563032672 0.0050635156 0.034962448 13 27075191 27075388 198 - 1.785 1.676 -0.368
ENSG00000152484 E004 0.315009 0.0332210256 0.3597696407   13 27089438 27089882 445 - 0.057 0.243 2.430
ENSG00000152484 E005 45.557630 0.0690818042 0.0041438393 0.029959924 13 27089883 27089966 84 - 1.562 1.376 -0.641
ENSG00000152484 E006 42.337717 0.0802843660 0.0093851221 0.055475447 13 27090082 27090158 77 - 1.531 1.349 -0.625
ENSG00000152484 E007 77.031412 0.0693990864 0.0266424056 0.117185249 13 27095601 27095830 230 - 1.770 1.708 -0.210
ENSG00000152484 E008 73.710109 0.0789298015 0.0760769916 0.236888624 13 27105731 27105944 214 - 1.746 1.716 -0.101
ENSG00000152484 E009 33.185858 0.0778000183 0.0360566169 0.144376399 13 27116516 27116596 81 - 1.422 1.304 -0.410
ENSG00000152484 E010 2.585152 0.0090172622 0.0007824666 0.008136723 13 27170091 27170329 239 - 0.264 0.928 3.164
ENSG00000152484 E011 20.091232 0.0377280577 0.8724149154 0.937258864 13 27171592 27171811 220 - 1.156 1.379 0.783