ENSG00000152404

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282251 ENSG00000152404 HEK293_OSMI2_6hA HEK293_TMG_6hB CWF19L2 protein_coding protein_coding 6.700494 2.073364 13.8195 0.0966972 0.5805435 2.730762 5.5336331 2.073364 10.240556 0.0966972 0.4969316 2.298715 0.87231667 1 0.7406333 -0.2593667 2.119279e-12 2.119279e-12 FALSE TRUE
MSTRG.6250.1 ENSG00000152404 HEK293_OSMI2_6hA HEK293_TMG_6hB CWF19L2 protein_coding   6.700494 2.073364 13.8195 0.0966972 0.5805435 2.730762 0.7537434 0.000000 3.169156 0.0000000 0.1672687 8.312500 0.07190417 0 0.2298667 0.2298667 1.882938e-10 2.119279e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152404 E001 1.0116638 0.0284735527 0.020715841   11 107311158 107311205 48 - 0.158 0.583 2.694
ENSG00000152404 E002 0.7804750 0.0193356278 0.868542353   11 107311206 107311232 27 - 0.200 0.234 0.286
ENSG00000152404 E003 68.4538348 0.0005480509 0.037726972 0.14890423 11 107326360 107326796 437 - 1.703 1.813 0.375
ENSG00000152404 E004 40.7964045 0.0194824186 0.072061245 0.22893621 11 107326797 107326908 112 - 1.471 1.644 0.590
ENSG00000152404 E005 16.8617260 0.0356128658 0.474181983 0.68295316 11 107326909 107326923 15 - 1.123 1.219 0.339
ENSG00000152404 E006 53.1505275 0.0009676385 0.174282101 0.39622889 11 107326924 107327053 130 - 1.602 1.687 0.289
ENSG00000152404 E007 50.9682242 0.0013944093 0.114820829 0.30714685 11 107329918 107330019 102 - 1.581 1.681 0.340
ENSG00000152404 E008 40.7124101 0.0080872062 0.132565782 0.33586034 11 107334881 107334961 81 - 1.480 1.598 0.403
ENSG00000152404 E009 49.4711931 0.0015973773 0.292156656 0.53282916 11 107336558 107336713 156 - 1.571 1.641 0.240
ENSG00000152404 E010 0.8048655 0.0202130346 0.383110817   11 107345414 107345490 77 - 0.238 0.001 -8.857
ENSG00000152404 E011 0.0000000       11 107348711 107348936 226 -      
ENSG00000152404 E012 45.2346309 0.0046499688 0.138054963 0.34454499 11 107348937 107349053 117 - 1.528 1.634 0.364
ENSG00000152404 E013 56.8444795 0.0042941045 0.013474468 0.07227652 11 107353524 107353678 155 - 1.611 1.769 0.535
ENSG00000152404 E014 42.1453020 0.0008979536 0.538614095 0.72803659 11 107353679 107353736 58 - 1.509 1.555 0.156
ENSG00000152404 E015 66.4180280 0.0007101279 0.028139417 0.12166714 11 107390074 107390211 138 - 1.729 1.604 -0.427
ENSG00000152404 E016 62.8279490 0.0038135880 0.093545581 0.27030663 11 107392779 107392895 117 - 1.703 1.597 -0.363
ENSG00000152404 E017 52.4119245 0.0022433604 0.138343095 0.34503590 11 107416209 107416298 90 - 1.625 1.528 -0.331
ENSG00000152404 E018 63.0574029 0.0103578622 0.515968479 0.71222254 11 107418194 107418287 94 - 1.696 1.649 -0.158
ENSG00000152404 E019 165.3222259 0.0004412817 0.008639018 0.05221976 11 107428799 107429451 653 - 2.116 2.027 -0.301
ENSG00000152404 E020 59.8670788 0.0035330166 0.265645585 0.50503471 11 107433634 107433749 116 - 1.673 1.605 -0.233
ENSG00000152404 E021 57.7151501 0.0006906863 0.215534158 0.44808973 11 107439090 107439183 94 - 1.660 1.588 -0.246
ENSG00000152404 E022 53.2672979 0.0014937580 0.139289214 0.34643481 11 107441503 107441622 120 - 1.630 1.537 -0.318
ENSG00000152404 E023 35.3342305 0.0349305098 0.627508325 0.78891128 11 107442939 107443049 111 - 1.452 1.411 -0.142
ENSG00000152404 E024 22.2775426 0.0422539755 0.520584023 0.71532021 11 107454450 107454572 123 - 1.233 1.336 0.361
ENSG00000152404 E025 32.9149920 0.0013750682 0.637597388 0.79547266 11 107455666 107455776 111 - 1.422 1.389 -0.115
ENSG00000152404 E026 26.3326537 0.0013675082 0.110889401 0.30042069 11 107457712 107457825 114 - 1.346 1.203 -0.504