ENSG00000152291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377386 ENSG00000152291 HEK293_OSMI2_6hA HEK293_TMG_6hB TGOLN2 protein_coding protein_coding 29.83535 29.10964 35.31671 1.33792 1.714696 0.278767 22.556674 21.2586263 27.832429 1.1260024 0.8758028 0.3885582 0.74991250 0.7299000 0.78966667 0.05976667 4.594837e-01 4.199663e-07 FALSE TRUE
ENST00000398263 ENSG00000152291 HEK293_OSMI2_6hA HEK293_TMG_6hB TGOLN2 protein_coding protein_coding 29.83535 29.10964 35.31671 1.33792 1.714696 0.278767 1.696508 0.6346238 2.667265 0.3569084 0.1492385 2.0542306 0.05195833 0.0230000 0.07546667 0.05246667 4.985714e-01 4.199663e-07 FALSE TRUE
MSTRG.18755.4 ENSG00000152291 HEK293_OSMI2_6hA HEK293_TMG_6hB TGOLN2 protein_coding   29.83535 29.10964 35.31671 1.33792 1.714696 0.278767 3.509637 5.1964173 1.585552 0.7478640 0.2094729 -1.7062355 0.13287083 0.1771667 0.04483333 -0.13233333 4.199663e-07 4.199663e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152291 E001 1.576812 0.01450748 0.1526112169 0.366052664 2 85313093 85313124 32 - 0.202 0.540 2.057
ENSG00000152291 E002 13.198078 0.02151556 0.0004627117 0.005334267 2 85318027 85318101 75 - 0.801 1.357 2.030
ENSG00000152291 E003 197.612980 1.01328861 0.3200206347 0.559757588 2 85318102 85318310 209 - 2.085 2.457 1.243
ENSG00000152291 E004 332.321376 1.19497310 0.3217079711 0.561213934 2 85318311 85318489 179 - 2.290 2.692 1.340
ENSG00000152291 E005 721.148284 1.47990366 0.3599634729 0.595711011 2 85318490 85319190 701 - 2.628 3.026 1.327
ENSG00000152291 E006 345.159624 1.21306720 0.3331489220 0.571766242 2 85319191 85319616 426 - 2.313 2.705 1.306
ENSG00000152291 E007 728.693381 1.52607893 0.4370452867 0.656472924 2 85319617 85320272 656 - 2.684 3.005 1.067
ENSG00000152291 E008 1362.411397 1.80521004 0.5686534031 0.749282585 2 85320273 85321893 1621 - 3.018 3.238 0.731
ENSG00000152291 E009 365.272392 1.35829713 0.5782321150 0.755990457 2 85321894 85322347 454 - 2.482 2.640 0.528
ENSG00000152291 E010 89.968497 0.57970305 0.4180337186 0.642163043 2 85322348 85322360 13 - 1.856 2.052 0.659
ENSG00000152291 E011 103.950042 0.63874028 0.4482422048 0.664430734 2 85322361 85322394 34 - 1.927 2.107 0.604
ENSG00000152291 E012 244.061613 1.19435327 0.5293143472 0.721565553 2 85322395 85322741 347 - 2.291 2.479 0.627
ENSG00000152291 E013 8.069046 0.09194266 0.5445631345 0.732329845 2 85322742 85322758 17 - 0.836 1.067 0.865
ENSG00000152291 E014 8.315325 0.11670959 0.4363828498 0.656059674 2 85322759 85322799 41 - 0.814 1.103 1.083
ENSG00000152291 E015 29.727012 0.33110542 0.4351404627 0.655084959 2 85324385 85324914 530 - 1.325 1.621 1.018
ENSG00000152291 E016 116.319655 0.69671216 0.5026842497 0.702635044 2 85324915 85324998 84 - 1.995 2.140 0.486
ENSG00000152291 E017 342.960099 0.05493351 0.0247490118 0.111445693 2 85326508 85326804 297 - 2.555 2.512 -0.143
ENSG00000152291 E018 208.393598 0.09095866 0.0801077244 0.245031233 2 85326805 85326978 174 - 2.343 2.291 -0.172
ENSG00000152291 E019 130.300907 0.10638715 0.1527088955 0.366224885 2 85326979 85327016 38 - 2.129 2.102 -0.090
ENSG00000152291 E020 180.050797 0.09572421 0.1081173423 0.295922564 2 85327017 85327134 118 - 2.274 2.235 -0.130
ENSG00000152291 E021 165.399553 0.08032436 0.1089165955 0.297269048 2 85327135 85327226 92 - 2.227 2.211 -0.055
ENSG00000152291 E022 143.733463 0.08270151 0.2695248962 0.509350532 2 85327227 85327273 47 - 2.135 2.185 0.167
ENSG00000152291 E023 109.194692 0.07864312 0.0395986346 0.153719316 2 85327274 85327302 29 - 2.079 1.992 -0.291
ENSG00000152291 E024 120.933024 0.08513522 0.0449005240 0.167357484 2 85327303 85327361 59 - 2.123 2.036 -0.294
ENSG00000152291 E025 102.666726 0.07385563 0.0125169155 0.068496766 2 85327362 85327386 25 - 2.073 1.935 -0.462
ENSG00000152291 E026 80.622752 0.07706037 0.0047737598 0.033390758 2 85327387 85327394 8 - 1.987 1.799 -0.633
ENSG00000152291 E027 89.266285 0.05970582 0.0466825335 0.171771453 2 85327395 85327399 5 - 1.973 1.931 -0.142
ENSG00000152291 E028 124.257092 0.08376087 0.0088309331 0.053065905 2 85327400 85327441 42 - 2.169 1.994 -0.586
ENSG00000152291 E029 135.540045 0.11175308 0.0635779189 0.210780710 2 85327442 85327483 42 - 2.175 2.082 -0.309
ENSG00000152291 E030 126.539477 0.11928657 0.0922718414 0.267947888 2 85327484 85327512 29 - 2.141 2.059 -0.275
ENSG00000152291 E031 205.590374 0.09603914 0.0832671590 0.251322825 2 85327513 85327685 173 - 2.339 2.283 -0.188
ENSG00000152291 E032 90.661506 0.08924549 0.1111903115 0.300943060 2 85327917 85328251 335 - 1.980 1.938 -0.140