ENSG00000152256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282077 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding protein_coding 7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.9526366 0.27250112 1.3894792 0.01641433 0.14007750 2.30856158 0.11530833 0.10153333 0.13003333 0.02850000 0.79666159 0.03903828 FALSE TRUE
ENST00000392571 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding protein_coding 7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.7662075 0.00000000 0.6684048 0.00000000 0.33750833 6.08407443 0.05712500 0.00000000 0.06266667 0.06266667 0.52311902 0.03903828 FALSE TRUE
MSTRG.19501.12 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 2.5680714 1.02170123 4.2496597 0.36680279 0.08795577 2.04571293 0.36233750 0.36433333 0.39650000 0.03216667 0.94014477 0.03903828 TRUE TRUE
MSTRG.19501.13 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.9041472 0.07229608 2.4485206 0.07229608 0.11574903 4.90082290 0.08622500 0.02376667 0.22826667 0.20450000 0.03903828 0.03903828 TRUE TRUE
MSTRG.19501.14 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.3578390 0.16930199 0.2372091 0.08527283 0.23720905 0.46334011 0.05846250 0.06730000 0.02093333 -0.04636667 0.61875814 0.03903828 TRUE TRUE
MSTRG.19501.3 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.2116698 0.24143093 0.2255608 0.24143093 0.22556078 -0.09406275 0.05621250 0.07943333 0.02260000 -0.05683333 0.94075921 0.03903828 TRUE TRUE
MSTRG.19501.7 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.6390417 0.51215856 0.2431211 0.32379931 0.24312108 -1.04466029 0.08014583 0.19483333 0.02146667 -0.17336667 0.52729247 0.03903828 TRUE TRUE
MSTRG.19501.8 ENSG00000152256 HEK293_OSMI2_6hA HEK293_TMG_6hB PDK1 protein_coding   7.947394 2.698685 10.75075 0.2373786 0.4020375 1.990113 0.7403316 0.00000000 0.0000000 0.00000000 0.00000000 0.00000000 0.06810417 0.00000000 0.00000000 0.00000000   0.03903828 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152256 E001 0.0000000       2 172555373 172555626 254 +      
ENSG00000152256 E002 0.0000000       2 172555627 172555719 93 +      
ENSG00000152256 E003 0.2735028 0.0279223814 4.012892e-01   2 172556007 172556050 44 + 0.073 0.195 1.631
ENSG00000152256 E004 0.1426347 0.0312767080 1.000000e+00   2 172556051 172556053 3 + 0.073 0.000 -9.094
ENSG00000152256 E005 0.9346885 0.2294566254 7.863811e-01   2 172556054 172556077 24 + 0.278 0.198 -0.633
ENSG00000152256 E006 1.5192562 0.0517767944 6.793550e-01 8.223218e-01 2 172556078 172556089 12 + 0.357 0.431 0.414
ENSG00000152256 E007 1.6618908 0.1070599014 7.999675e-01 8.963282e-01 2 172556090 172556101 12 + 0.388 0.430 0.228
ENSG00000152256 E008 3.3278954 0.3872553184 2.364464e-01 4.724728e-01 2 172556102 172556177 76 + 0.469 0.860 1.683
ENSG00000152256 E009 4.7012377 0.2695690338 1.194639e-01 3.149729e-01 2 172556178 172556253 76 + 0.589 0.958 1.489
ENSG00000152256 E010 5.0467943 0.2561812353 1.294407e-01 3.309149e-01 2 172556254 172556312 59 + 0.627 0.963 1.338
ENSG00000152256 E011 7.2474091 0.4209309710 5.817784e-01 7.582462e-01 2 172556313 172556346 34 + 0.851 0.910 0.229
ENSG00000152256 E012 0.1308682 0.0326491905 1.443269e-01   2 172556565 172556627 63 + 0.000 0.195 10.716
ENSG00000152256 E013 32.1628440 0.0015614328 5.534767e-01 7.386838e-01 2 172558708 172558849 142 + 1.452 1.485 0.114
ENSG00000152256 E014 31.9679529 0.0012728928 3.983828e-02 1.543025e-01 2 172562220 172562291 72 + 1.492 1.331 -0.556
ENSG00000152256 E015 6.9362672 0.0066122464 9.747561e-01 9.892668e-01 2 172562741 172562800 60 + 0.837 0.825 -0.044
ENSG00000152256 E016 0.3503582 0.0269254718 4.005583e-01   2 172564052 172564130 79 + 0.073 0.195 1.632
ENSG00000152256 E017 60.0845643 0.0008270260 2.813683e-03 2.227533e-02 2 172564503 172564687 185 + 1.758 1.586 -0.585
ENSG00000152256 E018 51.7648447 0.0034757589 4.995307e-02 1.795686e-01 2 172564978 172565073 96 + 1.684 1.553 -0.448
ENSG00000152256 E019 47.9151203 0.0148630665 3.196638e-01 5.594276e-01 2 172566856 172566933 78 + 1.645 1.555 -0.306
ENSG00000152256 E020 37.8890930 0.0012588709 7.964612e-01 8.942702e-01 2 172568741 172568817 77 + 1.522 1.531 0.031
ENSG00000152256 E021 0.6356275 0.0215154380 1.000000e+00   2 172570585 172570725 141 + 0.190 0.195 0.050
ENSG00000152256 E022 44.8274018 0.0014460199 3.779340e-02 1.490627e-01 2 172570726 172570824 99 + 1.565 1.678 0.383
ENSG00000152256 E023 48.7672342 0.0010399320 2.554156e-01 4.940481e-01 2 172586278 172586388 111 + 1.616 1.672 0.191
ENSG00000152256 E024 47.2538951 0.0019247328 2.572237e-01 4.959801e-01 2 172592935 172593048 114 + 1.603 1.662 0.200
ENSG00000152256 E025 50.4019599 0.0008643651 1.721377e-01 3.933900e-01 2 172595829 172596023 195 + 1.631 1.698 0.226
ENSG00000152256 E026 131.2189892 0.0095903325 2.204194e-07 7.510489e-06 2 172596024 172597612 1589 + 2.117 1.811 -1.028
ENSG00000152256 E027 147.3127426 0.0020488961 1.174928e-01 3.116242e-01 2 172597613 172608669 11057 + 2.095 2.141 0.153
ENSG00000152256 E028 7.9603200 0.0043878024 4.317422e-15 6.653335e-13 2 172614407 172614505 99 + 0.452 1.354 3.559
ENSG00000152256 E029 2.5114934 0.6318076912 3.291124e-01 5.681294e-01 2 172621424 172621502 79 + 0.328 0.795 2.212
ENSG00000152256 E030 1.2489394 0.0136968632 1.841204e-04   2 172626517 172626612 96 + 0.073 0.696 4.436
ENSG00000152256 E031 8.2809245 0.0154631319 6.774498e-06 1.497066e-04 2 172627829 172627998 170 + 0.703 1.241 2.022
ENSG00000152256 E032 0.1779838 0.0326251280 1.000000e+00   2 172670795 172670850 56 + 0.073 0.000 -9.090