ENSG00000152127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409645 ENSG00000152127 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT5 protein_coding protein_coding 15.77463 15.39482 15.04306 1.060905 0.5185602 -0.03332529 12.2518859 13.9211950 11.550857 1.00597371 0.7814615 -0.2690707 0.79214583 0.90400000 0.76670000 -0.13730000 0.0213921 0.0213921 FALSE TRUE
MSTRG.19256.2 ENSG00000152127 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT5 protein_coding   15.77463 15.39482 15.04306 1.060905 0.5185602 -0.03332529 0.5588724 0.1585366 0.923104 0.08383233 0.1837714 2.4689756 0.03111667 0.01023333 0.06113333 0.05090000 0.1260293 0.0213921 TRUE TRUE
MSTRG.19256.9 ENSG00000152127 HEK293_OSMI2_6hA HEK293_TMG_6hB MGAT5 protein_coding   15.77463 15.39482 15.04306 1.060905 0.5185602 -0.03332529 1.7378582 0.9875418 1.676640 0.08681209 0.5079420 0.7577026 0.10857083 0.06440000 0.11263333 0.04823333 0.7539143 0.0213921 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152127 E001 1.791448 0.1419403779 9.487548e-01 9.766075e-01 2 134119942 134119944 3 + 0.417 0.469 0.270
ENSG00000152127 E002 6.186269 0.0050063407 2.231105e-02 1.036281e-01 2 134119945 134119962 18 + 0.953 0.745 -0.808
ENSG00000152127 E003 9.562048 0.0033376362 2.295068e-01 4.645641e-01 2 134119963 134119982 20 + 1.050 1.005 -0.164
ENSG00000152127 E004 10.133991 0.0034187692 2.288839e-01 4.638837e-01 2 134119983 134120163 181 + 1.074 1.032 -0.152
ENSG00000152127 E005 1.453579 0.0966874920 2.892469e-01 5.297737e-01 2 134120164 134120181 18 + 0.215 0.477 1.639
ENSG00000152127 E006 11.957635 0.0025326391 1.786529e-01 4.021784e-01 2 134120182 134120291 110 + 1.129 1.082 -0.169
ENSG00000152127 E007 1.171532 0.2443171067 9.238546e-01   2 134190107 134190248 142 + 0.292 0.367 0.469
ENSG00000152127 E008 0.000000       2 134250050 134250052 3 +      
ENSG00000152127 E009 1.243210 0.0331851421 3.810940e-01   2 134250053 134250145 93 + 0.215 0.422 1.361
ENSG00000152127 E010 3.619797 0.0092459760 2.126299e-01 4.448197e-01 2 134253095 134253103 9 + 0.712 0.596 -0.497
ENSG00000152127 E011 12.953982 0.0025973399 2.616635e-02 1.158165e-01 2 134253104 134253218 115 + 1.196 1.071 -0.449
ENSG00000152127 E012 0.000000       2 134254072 134254261 190 +      
ENSG00000152127 E013 10.677283 0.0085516509 2.918585e-01 5.325352e-01 2 134254262 134254264 3 + 1.075 1.046 -0.103
ENSG00000152127 E014 117.342479 0.0103625901 1.754743e-07 6.140443e-06 2 134254265 134254644 380 + 2.165 1.957 -0.695
ENSG00000152127 E015 86.321186 0.0273048285 9.491301e-03 5.592500e-02 2 134270386 134270550 165 + 2.002 1.873 -0.432
ENSG00000152127 E016 67.688164 0.0028856420 6.172533e-09 3.026965e-07 2 134317529 134317605 77 + 1.926 1.728 -0.666
ENSG00000152127 E017 65.341304 0.0006207035 3.422961e-07 1.108500e-05 2 134318650 134318739 90 + 1.883 1.746 -0.461
ENSG00000152127 E018 57.699475 0.0099774252 4.586007e-03 3.240007e-02 2 134336217 134336288 72 + 1.813 1.712 -0.340
ENSG00000152127 E019 87.299251 0.0037721364 1.004533e-05 2.104814e-04 2 134338259 134338420 162 + 1.997 1.880 -0.393
ENSG00000152127 E020 111.233290 0.0022380466 2.316281e-04 3.019094e-03 2 134341590 134341759 170 + 2.072 2.018 -0.182
ENSG00000152127 E021 94.925535 0.0007539253 9.405625e-04 9.426329e-03 2 134344930 134345064 135 + 1.992 1.957 -0.118
ENSG00000152127 E022 92.192693 0.0004875282 2.854623e-04 3.581946e-03 2 134349805 134349938 134 + 1.988 1.942 -0.154
ENSG00000152127 E023 105.434214 0.0003907281 3.816369e-05 6.622123e-04 2 134362275 134362408 134 + 2.049 1.995 -0.181
ENSG00000152127 E024 117.489184 0.0042750926 7.532179e-03 4.717485e-02 2 134402988 134403137 150 + 2.081 2.056 -0.084
ENSG00000152127 E025 111.664871 0.0022924639 4.142185e-03 2.995266e-02 2 134412869 134413015 147 + 2.057 2.034 -0.076
ENSG00000152127 E026 101.041020 0.0005122373 1.927878e-02 9.343284e-02 2 134422803 134422919 117 + 2.000 2.005 0.017
ENSG00000152127 E027 81.062299 0.0004468322 7.137877e-01 8.442395e-01 2 134428365 134428439 75 + 1.872 1.946 0.250
ENSG00000152127 E028 112.919478 0.0056780426 5.873965e-01 7.618895e-01 2 134441758 134441915 158 + 2.024 2.088 0.215
ENSG00000152127 E029 440.961020 0.0006335115 8.540803e-02 2.553485e-01 2 134448649 134449860 1212 + 2.612 2.671 0.197
ENSG00000152127 E030 2034.520564 0.0049846947 2.581200e-11 2.071584e-09 2 134449861 134454621 4761 + 3.185 3.404 0.729
ENSG00000152127 E031 0.000000       2 134494472 134494527 56 +