ENSG00000152061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251507 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding protein_coding 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 1.19494574 0.6112813 1.5387275 0.26058176 0.28827083 1.317765 0.25927500 0.22200000 0.2259333 0.003933333 1.000000e+00 5.068194e-12 FALSE TRUE
ENST00000367690 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding protein_coding 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 0.27611892 0.2985366 0.3666176 0.01925005 0.07962764 0.287659 0.08023750 0.13373333 0.0537000 -0.080033333 2.591595e-01 5.068194e-12 FALSE TRUE
ENST00000392064 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding protein_coding 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 0.05126773 0.2805043 0.0000000 0.28050434 0.00000000 -4.860488 0.01783750 0.08803333 0.0000000 -0.088033333 7.608558e-01 5.068194e-12 FALSE TRUE
ENST00000485114 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding protein_coding 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 0.41769504 0.5085081 0.0000000 0.14099211 0.00000000 -5.696295 0.14809167 0.19916667 0.0000000 -0.199166667 5.068194e-12 5.068194e-12   FALSE
ENST00000529474 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding processed_transcript 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 0.41750941 0.1702507 0.7346674 0.08673650 0.29357030 2.046591 0.09475417 0.05553333 0.1100000 0.054466667 8.211819e-01 5.068194e-12   FALSE
ENST00000681986 ENSG00000152061 HEK293_OSMI2_6hA HEK293_TMG_6hB RABGAP1L protein_coding protein_coding 4.454008 2.500023 6.739781 0.5846815 0.2763313 1.42714 1.53388102 0.3606074 3.1867629 0.20247923 0.03210676 3.108648 0.28522500 0.17350000 0.4743667 0.300866667 4.668532e-01 5.068194e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000152061 E001 0.5363366 0.0236309482 4.130800e-03   1 174159410 174159472 63 + 0.000 0.463 13.877
ENSG00000152061 E002 1.3707542 0.0250894129 1.290766e-02   1 174159473 174159501 29 + 0.174 0.621 2.686
ENSG00000152061 E003 1.7161231 0.0226862598 8.874321e-03 5.326025e-02 1 174159502 174159516 15 + 0.219 0.683 2.537
ENSG00000152061 E004 1.7161231 0.0226862598 8.874321e-03 5.326025e-02 1 174159517 174159519 3 + 0.219 0.683 2.537
ENSG00000152061 E005 8.4795927 0.0066176230 1.976788e-01 4.266756e-01 1 174159520 174159580 61 + 0.859 1.022 0.610
ENSG00000152061 E006 8.3487246 0.0090290918 2.940393e-01 5.346493e-01 1 174159581 174159589 9 + 0.859 0.995 0.513
ENSG00000152061 E007 13.2390116 0.0035782197 4.553197e-01 6.697548e-01 1 174159590 174159657 68 + 1.055 1.136 0.294
ENSG00000152061 E008 13.6903962 0.0040024174 9.916842e-01 9.975701e-01 1 174219125 174219163 39 + 1.091 1.093 0.010
ENSG00000152061 E009 8.4680504 0.0273283019 9.868079e-01 9.952589e-01 1 174219164 174219184 21 + 0.903 0.902 -0.007
ENSG00000152061 E010 11.0299608 0.0029355670 4.635438e-01 6.755202e-01 1 174219185 174219247 63 + 1.022 0.934 -0.327
ENSG00000152061 E011 11.4568693 0.0029503958 9.785022e-01 9.910304e-01 1 174219248 174219295 48 + 1.022 1.021 -0.005
ENSG00000152061 E012 0.3150090 0.0340347236 3.198040e-01   1 174220712 174220971 260 + 0.066 0.213 1.951
ENSG00000152061 E013 26.9200708 0.0052315204 9.796284e-01 9.916275e-01 1 174220972 174221164 193 + 1.367 1.364 -0.010
ENSG00000152061 E014 29.7688937 0.0092991813 6.067760e-01 7.747142e-01 1 174231145 174231355 211 + 1.399 1.439 0.139
ENSG00000152061 E015 2.4458799 0.0087709755 4.705263e-01 6.804410e-01 1 174238822 174238949 128 + 0.496 0.356 -0.752
ENSG00000152061 E016 28.2681625 0.0013241672 7.831127e-01 8.864890e-01 1 174241483 174241657 175 + 1.386 1.365 -0.073
ENSG00000152061 E017 5.7229887 0.0608911562 1.761479e-01 3.986508e-01 1 174242982 174243179 198 + 0.799 0.543 -1.087
ENSG00000152061 E018 34.4323727 0.0139956975 6.785668e-01 8.218363e-01 1 174244298 174246346 2049 + 1.471 1.429 -0.143
ENSG00000152061 E019 21.7060067 0.0015302478 8.107443e-01 9.026910e-01 1 174250475 174250632 158 + 1.265 1.287 0.077
ENSG00000152061 E020 0.1308682 0.0326491905 1.102679e-01   1 174252444 174252479 36 + 0.000 0.213 14.733
ENSG00000152061 E021 23.0603622 0.0016310588 3.501856e-01 5.873982e-01 1 174252480 174252590 111 + 1.309 1.226 -0.292
ENSG00000152061 E022 21.1051466 0.0017053171 1.195631e-01 3.151318e-01 1 174272414 174272480 67 + 1.284 1.136 -0.526
ENSG00000152061 E023 0.1779838 0.0359985688 1.000000e+00   1 174275100 174275189 90 + 0.066 0.000 -12.965
ENSG00000152061 E024 28.0047110 0.0013690890 4.398214e-01 6.585649e-01 1 174275833 174275935 103 + 1.389 1.328 -0.213
ENSG00000152061 E025 37.4672454 0.0041572330 3.610869e-01 5.965299e-01 1 174278613 174278779 167 + 1.511 1.441 -0.242
ENSG00000152061 E026 33.6079240 0.0014574259 8.068980e-02 2.461997e-01 1 174304986 174305127 142 + 1.476 1.341 -0.468
ENSG00000152061 E027 0.0000000       1 174365230 174365309 80 +      
ENSG00000152061 E028 24.5243062 0.0025847591 1.406387e-01 3.485194e-01 1 174370979 174371072 94 + 1.343 1.210 -0.467
ENSG00000152061 E029 29.7723276 0.0087009909 1.447793e-01 3.546365e-01 1 174393995 174394145 151 + 1.424 1.288 -0.470
ENSG00000152061 E030 9.2414652 0.0045592041 2.422511e-07 8.164281e-06 1 174544844 174545911 1068 + 0.735 1.301 2.098
ENSG00000152061 E031 0.1779838 0.0359985688 1.000000e+00   1 174547837 174548561 725 + 0.066 0.000 -12.965
ENSG00000152061 E032 13.3676636 0.0175625932 6.198469e-01 7.837352e-01 1 174637375 174637377 3 + 1.081 1.022 -0.217
ENSG00000152061 E033 24.3176639 0.0345682190 3.644840e-01 5.994464e-01 1 174637378 174637488 111 + 1.336 1.227 -0.383
ENSG00000152061 E034 19.4074468 0.0078187887 4.050111e-01 6.322697e-01 1 174683522 174683596 75 + 1.242 1.155 -0.306
ENSG00000152061 E035 22.9244545 0.0024072849 4.846422e-01 6.902645e-01 1 174699525 174699650 126 + 1.280 1.341 0.210
ENSG00000152061 E036 0.0000000       1 174700413 174700524 112 +      
ENSG00000152061 E037 0.0000000       1 174700525 174700730 206 +      
ENSG00000152061 E038 0.0000000       1 174700731 174700746 16 +      
ENSG00000152061 E039 0.0000000       1 174700747 174700865 119 +      
ENSG00000152061 E040 0.0000000       1 174701020 174701021 2 +      
ENSG00000152061 E041 0.0000000       1 174701022 174701122 101 +      
ENSG00000152061 E042 0.0000000       1 174701123 174701145 23 +      
ENSG00000152061 E043 20.7552770 0.0025789222 2.455781e-01 4.830859e-01 1 174702113 174702256 144 + 1.225 1.328 0.361
ENSG00000152061 E044 0.1308682 0.0326491905 1.102679e-01   1 174705201 174705750 550 + 0.000 0.213 14.733
ENSG00000152061 E045 11.5239809 0.0029354471 6.298030e-01 7.903525e-01 1 174752313 174752354 42 + 1.023 0.966 -0.210
ENSG00000152061 E046 0.3559677 0.5119858382 1.000000e+00   1 174799932 174800500 569 + 0.127 0.000 -13.089
ENSG00000152061 E047 21.9176769 0.0021034647 9.812178e-01 9.923817e-01 1 174811832 174811960 129 + 1.269 1.273 0.013
ENSG00000152061 E048 0.2027342 0.0328646334 1.094201e-01   1 174874458 174874470 13 + 0.000 0.214 14.737
ENSG00000152061 E049 0.0000000       1 174874471 174874506 36 +      
ENSG00000152061 E050 0.0000000       1 174875546 174875713 168 +      
ENSG00000152061 E051 0.3088520 0.0261546279 3.242768e-01   1 174877392 174877439 48 + 0.066 0.213 1.943
ENSG00000152061 E052 0.3088520 0.0261546279 3.242768e-01   1 174877440 174877605 166 + 0.066 0.213 1.943
ENSG00000152061 E053 21.5660858 0.0022813204 2.323015e-01 4.678955e-01 1 174957457 174957549 93 + 1.249 1.353 0.363
ENSG00000152061 E054 4.9072830 0.0076714826 2.134637e-06 5.526073e-05 1 174957891 174958173 283 + 0.473 1.115 2.609
ENSG00000152061 E055 0.1308682 0.0326491905 1.102679e-01   1 174958174 174958187 14 + 0.000 0.213 14.733
ENSG00000152061 E056 0.1426347 0.0325890121 1.000000e+00   1 174964768 174964958 191 + 0.066 0.000 -12.983
ENSG00000152061 E057 0.0000000       1 174964959 174964985 27 +      
ENSG00000152061 E058 18.8405974 0.0023697628 2.798561e-01 5.199444e-01 1 174969277 174969387 111 + 1.241 1.135 -0.375
ENSG00000152061 E059 0.1426347 0.0325890121 1.000000e+00   1 174976029 174976077 49 + 0.066 0.000 -12.983
ENSG00000152061 E060 17.5634619 0.0139695879 2.603076e-02 1.154089e-01 1 174976078 174976182 105 + 1.235 0.964 -0.980
ENSG00000152061 E061 12.4419707 0.0288164892 4.072878e-02 1.566136e-01 1 174978807 174978890 84 + 1.099 0.784 -1.184
ENSG00000152061 E062 12.1912428 0.0132647870 1.159385e-01 3.090317e-01 1 174982834 174982905 72 + 1.078 0.866 -0.790
ENSG00000152061 E063 18.3966102 0.0029405280 3.685804e-01 6.028917e-01 1 174988641 174988838 198 + 1.224 1.136 -0.314
ENSG00000152061 E064 174.8625262 0.0003271844 2.697908e-02 1.182458e-01 1 174989849 174993586 3738 + 2.170 2.102 -0.227
ENSG00000152061 E065 100.9399545 0.0006569182 6.970837e-08 2.687220e-06 1 174993587 174995308 1722 + 1.867 2.075 0.698