ENSG00000151806

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281543 ENSG00000151806 HEK293_OSMI2_6hA HEK293_TMG_6hB GUF1 protein_coding protein_coding 11.10475 4.581219 16.74076 1.109193 0.9979113 1.867277 4.5028338 2.1260630 6.214440 0.75063531 0.2500493 1.542990 0.40689167 0.47176667 0.3722667 -0.09950000 8.655677e-01 1.38894e-09 FALSE TRUE
ENST00000506793 ENSG00000151806 HEK293_OSMI2_6hA HEK293_TMG_6hB GUF1 protein_coding processed_transcript 11.10475 4.581219 16.74076 1.109193 0.9979113 1.867277 1.6902699 1.1757502 3.364568 0.09473645 0.6887270 1.508903 0.18120833 0.28846667 0.1974000 -0.09106667 7.430779e-01 1.38894e-09 FALSE TRUE
MSTRG.24820.1 ENSG00000151806 HEK293_OSMI2_6hA HEK293_TMG_6hB GUF1 protein_coding   11.10475 4.581219 16.74076 1.109193 0.9979113 1.867277 1.5436513 0.0000000 2.607804 0.00000000 0.3443160 8.032213 0.09073750 0.00000000 0.1568667 0.15686667 1.388940e-09 1.38894e-09 FALSE TRUE
MSTRG.24820.4 ENSG00000151806 HEK293_OSMI2_6hA HEK293_TMG_6hB GUF1 protein_coding   11.10475 4.581219 16.74076 1.109193 0.9979113 1.867277 0.6611783 0.6453292 0.000000 0.64532916 0.0000000 -6.034148 0.08180417 0.10350000 0.0000000 -0.10350000 7.127051e-01 1.38894e-09 FALSE TRUE
MSTRG.24820.7 ENSG00000151806 HEK293_OSMI2_6hA HEK293_TMG_6hB GUF1 protein_coding   11.10475 4.581219 16.74076 1.109193 0.9979113 1.867277 1.1880266 0.3626744 1.959273 0.36267442 0.9826408 2.401675 0.12872083 0.05816667 0.1238333 0.06566667 7.856428e-01 1.38894e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151806 E001 0.3040503 0.0244411696 6.953543e-01   4 44678420 44678426 7 + 0.140 0.000 -9.020
ENSG00000151806 E002 4.5582459 0.1505361464 3.851641e-01 0.6166356424 4 44678427 44678454 28 + 0.656 0.814 0.642
ENSG00000151806 E003 13.1528626 0.4891825413 4.116472e-01 0.6372742476 4 44678455 44678493 39 + 1.043 1.229 0.667
ENSG00000151806 E004 19.4178001 0.2989672940 4.838320e-01 0.6896575352 4 44678494 44678585 92 + 1.228 1.336 0.381
ENSG00000151806 E005 40.9525932 0.0060236932 9.018415e-01 0.9528259589 4 44678586 44678787 202 + 1.566 1.593 0.093
ENSG00000151806 E006 44.7668338 0.0015902032 5.985297e-01 0.7692899649 4 44680441 44680552 112 + 1.612 1.605 -0.024
ENSG00000151806 E007 79.6155693 0.0011447307 4.397341e-02 0.1650100873 4 44680694 44680842 149 + 1.876 1.805 -0.240
ENSG00000151806 E008 67.2752250 0.0383826971 9.172584e-01 0.9608292950 4 44681123 44681203 81 + 1.788 1.769 -0.064
ENSG00000151806 E009 55.9455857 0.9465495918 5.263058e-01 0.7194024043 4 44682334 44682411 78 + 1.681 1.754 0.246
ENSG00000151806 E010 51.6023975 0.0090067279 6.109823e-01 0.7776042738 4 44683235 44683318 84 + 1.657 1.705 0.162
ENSG00000151806 E011 56.6654437 0.0007000237 4.585852e-01 0.6722108031 4 44685959 44686023 65 + 1.695 1.758 0.213
ENSG00000151806 E012 115.0476974 0.0005933168 2.885942e-04 0.0036140356 4 44686510 44686713 204 + 2.042 1.927 -0.385
ENSG00000151806 E013 78.4304486 0.0018032261 7.464719e-03 0.0468557002 4 44688007 44688146 140 + 1.874 1.766 -0.364
ENSG00000151806 E014 74.0497934 0.0013933661 6.579582e-03 0.0426019646 4 44689286 44689409 124 + 1.852 1.744 -0.362
ENSG00000151806 E015 79.1051732 0.0057441135 4.227168e-01 0.6456803373 4 44689843 44689975 133 + 1.858 1.845 -0.041
ENSG00000151806 E016 83.9361999 0.0005807742 4.465400e-01 0.6631056539 4 44690717 44690860 144 + 1.884 1.876 -0.025
ENSG00000151806 E017 89.5803202 0.0004936084 5.901186e-01 0.7638218383 4 44691666 44691799 134 + 1.907 1.910 0.009
ENSG00000151806 E018 0.8296159 0.1097396054 7.919650e-01   4 44694409 44694411 3 + 0.246 0.191 -0.464
ENSG00000151806 E019 89.4358440 0.0006149519 7.573994e-01 0.8710794007 4 44694412 44694513 102 + 1.895 1.933 0.128
ENSG00000151806 E020 91.0301643 0.0054355276 9.220960e-01 0.9633238703 4 44695615 44695734 120 + 1.906 1.924 0.061
ENSG00000151806 E021 63.9701798 0.0006435299 3.955581e-01 0.6248475542 4 44697408 44697444 37 + 1.770 1.754 -0.055
ENSG00000151806 E022 98.7244639 0.0004212706 5.176458e-01 0.7133897819 4 44698544 44698684 141 + 1.947 1.947 -0.002
ENSG00000151806 E023 125.3473958 0.0088146402 8.795530e-01 0.9410831250 4 44698685 44699219 535 + 2.043 2.054 0.038
ENSG00000151806 E024 303.5481872 0.0059256964 4.213593e-05 0.0007190885 4 44699220 44700840 1621 + 2.376 2.552 0.590
ENSG00000151806 E025 40.0895197 0.0121493683 7.505369e-01 0.8670523958 4 44700841 44701227 387 + 1.558 1.552 -0.020
ENSG00000151806 E026 1.6594355 0.0478609602 3.019798e-02 0.1279263327 4 44713215 44713519 305 + 0.465 0.000 -11.349