ENSG00000151725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281453 ENSG00000151725 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPU protein_coding protein_coding 42.35204 13.94889 79.4817 1.40395 3.893935 2.50962 12.060312 3.6833917 22.063098 0.551003580 0.6272064 2.579271 0.2824958 0.26146667 0.27833333 0.01686667 0.91173035 0.0002209139 FALSE TRUE
ENST00000502461 ENSG00000151725 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPU protein_coding retained_intron 42.35204 13.94889 79.4817 1.40395 3.893935 2.50962 3.321129 1.9774864 5.763496 0.002553741 0.6405357 1.538500 0.1111833 0.14476667 0.07206667 -0.07270000 0.01622900 0.0002209139   FALSE
ENST00000510146 ENSG00000151725 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPU protein_coding nonsense_mediated_decay 42.35204 13.94889 79.4817 1.40395 3.893935 2.50962 22.988251 7.3578120 40.583616 1.038522388 2.0522904 2.461945 0.5247375 0.52293333 0.51060000 -0.01233333 0.96302529 0.0002209139 TRUE TRUE
MSTRG.25808.6 ENSG00000151725 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPU protein_coding   42.35204 13.94889 79.4817 1.40395 3.893935 2.50962 2.440276 0.2973223 6.917020 0.067317484 0.9228451 4.494410 0.0445125 0.02273333 0.08696667 0.06423333 0.01134888 0.0002209139 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151725 E001 42.8249631 0.2331147474 2.226438e-01 4.566443e-01 4 184694085 184695001 917 - 1.490 1.679 0.647
ENSG00000151725 E002 102.2828577 0.0036135358 5.545658e-03 3.744971e-02 4 184695002 184695128 127 - 1.873 2.011 0.463
ENSG00000151725 E003 366.4978543 0.0002214057 7.829124e-07 2.296313e-05 4 184695129 184695348 220 - 2.428 2.541 0.375
ENSG00000151725 E004 239.7779347 0.0002339595 1.504591e-03 1.364853e-02 4 184695349 184695401 53 - 2.250 2.341 0.304
ENSG00000151725 E005 405.5217945 0.0001736794 7.844358e-01 8.871908e-01 4 184697647 184697803 157 - 2.495 2.502 0.025
ENSG00000151725 E006 32.0735841 0.0030264612 1.469547e-03 1.340150e-02 4 184697804 184698096 293 - 1.353 1.589 0.811
ENSG00000151725 E007 19.2728616 0.0026216392 6.852656e-02 2.217912e-01 4 184698194 184698318 125 - 1.158 1.329 0.602
ENSG00000151725 E008 263.0000520 0.0002043811 4.859610e-01 6.912147e-01 4 184700820 184700881 62 - 2.312 2.294 -0.060
ENSG00000151725 E009 24.3182906 0.0121524806 1.232272e-02 6.773039e-02 4 184701905 184702088 184 - 1.329 1.034 -1.050
ENSG00000151725 E010 236.1459933 0.0002171868 3.918169e-02 1.526416e-01 4 184702089 184702136 48 - 2.272 2.211 -0.205
ENSG00000151725 E011 3.3380822 0.0068211776 3.013957e-01 5.418812e-01 4 184702137 184702362 226 - 0.583 0.380 -1.013
ENSG00000151725 E012 274.4638669 0.0033759579 4.096387e-01 6.357694e-01 4 184702363 184702441 79 - 2.333 2.301 -0.109
ENSG00000151725 E013 0.9770522 0.0156974633 3.576622e-01   4 184702442 184702481 40 - 0.203 0.380 1.235
ENSG00000151725 E014 284.8584714 0.0002602697 4.359573e-01 6.557507e-01 4 184710072 184710147 76 - 2.347 2.327 -0.067
ENSG00000151725 E015 207.0834940 0.0002407500 8.975652e-01 9.505966e-01 4 184710148 184710180 33 - 2.204 2.202 -0.009
ENSG00000151725 E016 0.3503582 0.0306173256 2.590387e-01   4 184710326 184710406 81 - 0.060 0.231 2.235
ENSG00000151725 E017 293.7963780 0.0001816839 6.287741e-02 2.091924e-01 4 184712944 184713013 70 - 2.364 2.315 -0.162
ENSG00000151725 E018 0.1723744 0.0358146062 8.435172e-02   4 184713869 184713941 73 - 0.000 0.231 11.589
ENSG00000151725 E019 491.0621360 0.0003735808 3.934927e-01 6.231442e-01 4 184716397 184716633 237 - 2.580 2.563 -0.056
ENSG00000151725 E020 257.4373336 0.0011963060 2.638962e-01 5.031564e-01 4 184717136 184717196 61 - 2.304 2.269 -0.115
ENSG00000151725 E021 292.0620368 0.0002653122 2.386291e-01 4.750510e-01 4 184724957 184725062 106 - 2.358 2.328 -0.101
ENSG00000151725 E022 262.9996441 0.0005423750 3.765428e-02 1.487339e-01 4 184728918 184729035 118 - 2.318 2.257 -0.203
ENSG00000151725 E023 146.1079825 0.0004108340 1.717987e-01 3.929348e-01 4 184730920 184730968 49 - 2.064 2.013 -0.171
ENSG00000151725 E024 1.6123198 0.0117953824 5.074312e-01 7.059928e-01 4 184733298 184733414 117 - 0.369 0.230 -0.938
ENSG00000151725 E025 98.2734248 0.0030402928 6.981957e-01 8.344071e-01 4 184734016 184734130 115 - 1.887 1.870 -0.057