ENSG00000151718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403733 ENSG00000151718 HEK293_OSMI2_6hA HEK293_TMG_6hB WWC2 protein_coding protein_coding 3.91457 1.730699 7.187377 0.425014 0.1332392 2.047804 2.36582363 1.09334517 4.0664286 0.21922573 0.5724796 1.885422 0.57080833 0.67330000 0.56526667 -0.10803333 0.81105694 0.02601303 FALSE TRUE
ENST00000448232 ENSG00000151718 HEK293_OSMI2_6hA HEK293_TMG_6hB WWC2 protein_coding protein_coding 3.91457 1.730699 7.187377 0.425014 0.1332392 2.047804 0.32842471 0.04171308 0.6046434 0.04171308 0.2281105 3.571148 0.09575000 0.01943333 0.08466667 0.06523333 0.42157316 0.02601303 FALSE TRUE
ENST00000504005 ENSG00000151718 HEK293_OSMI2_6hA HEK293_TMG_6hB WWC2 protein_coding protein_coding 3.91457 1.730699 7.187377 0.425014 0.1332392 2.047804 0.07083362 0.21138538 0.0000000 0.21138538 0.0000000 -4.468488 0.04983750 0.09840000 0.00000000 -0.09840000 0.69975829 0.02601303 FALSE TRUE
ENST00000515284 ENSG00000151718 HEK293_OSMI2_6hA HEK293_TMG_6hB WWC2 protein_coding retained_intron 3.91457 1.730699 7.187377 0.425014 0.1332392 2.047804 0.56060294 0.20908548 1.4825408 0.04424418 0.2320387 2.768205 0.12191667 0.12776667 0.20530000 0.07753333 0.55533481 0.02601303   FALSE
MSTRG.25781.4 ENSG00000151718 HEK293_OSMI2_6hA HEK293_TMG_6hB WWC2 protein_coding   3.91457 1.730699 7.187377 0.425014 0.1332392 2.047804 0.36446981 0.00000000 0.8355334 0.00000000 0.3254944 6.401790 0.08638333 0.00000000 0.11686667 0.11686667 0.02601303 0.02601303 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151718 E001 2.9623380 0.0082002660 0.7276401712 0.852817549 4 183099257 183099338 82 + 0.530 0.607 0.350
ENSG00000151718 E002 6.4435665 0.0044185467 0.0412147375 0.157905562 4 183099339 183099491 153 + 0.722 1.006 1.098
ENSG00000151718 E003 16.9361201 0.0027548931 0.7993191424 0.895915035 4 183099492 183099622 131 + 1.166 1.211 0.157
ENSG00000151718 E004 14.0214141 0.0220131133 0.9310146693 0.967528512 4 183193599 183193614 16 + 1.100 1.120 0.069
ENSG00000151718 E005 24.4152836 0.0018763482 0.0522974577 0.185049782 4 183193615 183193708 94 + 1.359 1.210 -0.522
ENSG00000151718 E006 0.1426347 0.0327404087 1.0000000000   4 183203516 183203603 88 + 0.068 0.000 -8.674
ENSG00000151718 E007 46.3525689 0.0009600540 0.0366636379 0.145994096 4 183207953 183208156 204 + 1.623 1.514 -0.373
ENSG00000151718 E008 20.7706679 0.0067186476 0.0820348189 0.248814971 4 183208949 183208978 30 + 1.293 1.139 -0.545
ENSG00000151718 E009 26.5044643 0.0019888926 0.0037982189 0.028010462 4 183208979 183209025 47 + 1.408 1.176 -0.814
ENSG00000151718 E010 28.8255789 0.0016369689 0.0007630158 0.007969594 4 183240183 183240262 80 + 1.445 1.176 -0.938
ENSG00000151718 E011 33.7242008 0.0012616195 0.1001741081 0.282108532 4 183245416 183245545 130 + 1.483 1.383 -0.343
ENSG00000151718 E012 37.3404067 0.0019989966 0.1771872401 0.400043456 4 183248714 183248860 147 + 1.526 1.453 -0.250
ENSG00000151718 E013 28.8413718 0.0212206657 0.0180582243 0.089233911 4 183249920 183249993 74 + 1.448 1.206 -0.844
ENSG00000151718 E014 46.1885466 0.0010279946 0.1754454304 0.397744081 4 183253757 183253999 243 + 1.614 1.553 -0.210
ENSG00000151718 E015 32.8056474 0.0012757013 0.7252438730 0.851285192 4 183259639 183259728 90 + 1.442 1.489 0.163
ENSG00000151718 E016 80.8925398 0.0035400735 0.7171903323 0.846400920 4 183260910 183261385 476 + 1.837 1.842 0.019
ENSG00000151718 E017 43.5100302 0.0061234466 0.5022344757 0.702316614 4 183261386 183261532 147 + 1.581 1.558 -0.079
ENSG00000151718 E018 41.0125115 0.0008621056 0.8309999794 0.914348214 4 183264978 183265107 130 + 1.544 1.553 0.031
ENSG00000151718 E019 31.5486673 0.0065432508 0.8026797253 0.897856548 4 183265688 183265768 81 + 1.420 1.464 0.149
ENSG00000151718 E020 20.2133391 0.0057064770 0.5152926538 0.711862493 4 183265865 183265868 4 + 1.228 1.312 0.295
ENSG00000151718 E021 35.3451102 0.0012079412 0.3535222966 0.590460153 4 183265869 183265951 83 + 1.460 1.546 0.293
ENSG00000151718 E022 42.2019528 0.0010514398 0.4425113738 0.660392916 4 183268971 183269118 148 + 1.544 1.615 0.242
ENSG00000151718 E023 29.3038888 0.0017849124 0.6422214475 0.798317548 4 183269119 183269163 45 + 1.396 1.453 0.196
ENSG00000151718 E024 0.1779838 0.0364047146 1.0000000000   4 183269419 183269603 185 + 0.069 0.000 -8.678
ENSG00000151718 E025 0.9040708 0.2244116796 0.4503410909   4 183269762 183269850 89 + 0.181 0.353 1.284
ENSG00000151718 E026 0.7260870 0.1317000940 0.2646089531   4 183269851 183270038 188 + 0.128 0.351 1.862
ENSG00000151718 E027 40.3661239 0.0021322141 0.4313914135 0.652236575 4 183271080 183271211 132 + 1.544 1.514 -0.105
ENSG00000151718 E028 29.9400163 0.0026180053 0.9791233500 0.991329924 4 183271212 183271241 30 + 1.411 1.434 0.077
ENSG00000151718 E029 47.0658491 0.0019786691 0.0237183218 0.108213878 4 183280776 183280897 122 + 1.629 1.506 -0.421
ENSG00000151718 E030 4.6305212 0.0195474811 0.0057976925 0.038732555 4 183280898 183280969 72 + 0.751 0.207 -2.924
ENSG00000151718 E031 9.5886735 0.0126923308 0.0939911766 0.271134566 4 183280970 183281386 417 + 0.989 0.769 -0.844
ENSG00000151718 E032 4.7519059 0.0162566687 0.0757184583 0.236219932 4 183282607 183282707 101 + 0.750 0.451 -1.342
ENSG00000151718 E033 56.2820053 0.0006582994 0.2566770739 0.495438507 4 183282708 183282906 199 + 1.692 1.652 -0.135
ENSG00000151718 E034 52.9348408 0.0009227806 0.7680997157 0.877474676 4 183284226 183284390 165 + 1.647 1.686 0.132
ENSG00000151718 E035 42.0970993 0.0128516975 0.5850982727 0.760383730 4 183285967 183286059 93 + 1.543 1.597 0.183
ENSG00000151718 E036 61.6575490 0.0007414037 0.1267359019 0.326608171 4 183289393 183289635 243 + 1.696 1.796 0.338
ENSG00000151718 E037 47.8714733 0.0008460906 0.2451016950 0.482428201 4 183312341 183312454 114 + 1.590 1.680 0.306
ENSG00000151718 E038 23.9270774 0.0018077683 0.1155683280 0.308426852 4 183312455 183312468 14 + 1.289 1.434 0.507
ENSG00000151718 E039 279.5523547 0.0111718547 0.0060069787 0.039755384 4 183315663 183320777 5115 + 2.329 2.484 0.520