ENSG00000151576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281273 ENSG00000151576 HEK293_OSMI2_6hA HEK293_TMG_6hB QTRT2 protein_coding protein_coding 27.67637 16.75953 40.39254 3.531055 1.521289 1.268604 8.839463 4.5892760 12.909751 1.5913998 1.1240710 1.490100 0.29332917 0.25453333 0.31850000 0.06396667 7.697237e-01 4.178859e-21 FALSE TRUE
ENST00000462966 ENSG00000151576 HEK293_OSMI2_6hA HEK293_TMG_6hB QTRT2 protein_coding protein_coding 27.67637 16.75953 40.39254 3.531055 1.521289 1.268604 1.414116 3.2364345 0.000000 0.9812177 0.0000000 -8.342712 0.08284583 0.19183333 0.00000000 -0.19183333 4.178859e-21 4.178859e-21 FALSE FALSE
ENST00000483272 ENSG00000151576 HEK293_OSMI2_6hA HEK293_TMG_6hB QTRT2 protein_coding retained_intron 27.67637 16.75953 40.39254 3.531055 1.521289 1.268604 1.715827 0.3746103 1.710281 0.3301859 0.3998576 2.161175 0.08614167 0.01996667 0.04223333 0.02226667 6.187948e-01 4.178859e-21 FALSE FALSE
ENST00000485050 ENSG00000151576 HEK293_OSMI2_6hA HEK293_TMG_6hB QTRT2 protein_coding protein_coding 27.67637 16.75953 40.39254 3.531055 1.521289 1.268604 10.038914 5.7546884 14.540213 0.5066593 1.1718262 1.335726 0.34617500 0.37140000 0.35943333 -0.01196667 1.000000e+00 4.178859e-21 FALSE TRUE
ENST00000493014 ENSG00000151576 HEK293_OSMI2_6hA HEK293_TMG_6hB QTRT2 protein_coding protein_coding 27.67637 16.75953 40.39254 3.531055 1.521289 1.268604 1.468335 1.0801909 4.536498 0.5073795 0.6087482 2.060175 0.04731667 0.05683333 0.11300000 0.05616667 5.074372e-01 4.178859e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151576 E001 0.0000000       3 114005833 114006032 200 +      
ENSG00000151576 E002 0.7765309 0.6362790450 0.9119318419   3 114056709 114056734 26 + 0.268 0.168 -0.855
ENSG00000151576 E003 0.7765309 0.6362790450 0.9119318419   3 114056735 114056736 2 + 0.268 0.168 -0.855
ENSG00000151576 E004 0.7765309 0.6362790450 0.9119318419   3 114056737 114056739 3 + 0.268 0.168 -0.855
ENSG00000151576 E005 1.7639216 0.4349554990 0.4730440255 0.682193881 3 114056740 114056750 11 + 0.360 0.533 0.900
ENSG00000151576 E006 4.5794205 0.1130662215 0.2947485428 0.535291487 3 114056751 114056756 6 + 0.644 0.863 0.886
ENSG00000151576 E007 11.8912671 0.0056072208 0.5816262605 0.758179647 3 114056757 114056781 25 + 1.095 1.071 -0.087
ENSG00000151576 E008 28.8913407 0.0317734799 0.3012518548 0.541719517 3 114056782 114056803 22 + 1.473 1.389 -0.289
ENSG00000151576 E009 77.2026874 0.0037227047 0.3502312637 0.587441963 3 114056804 114056864 61 + 1.868 1.858 -0.034
ENSG00000151576 E010 0.8995767 0.0175612367 0.3754450061   3 114056967 114056998 32 + 0.214 0.392 1.206
ENSG00000151576 E011 36.8123560 0.0503051610 0.1698798667 0.390306549 3 114056999 114057021 23 + 1.573 1.486 -0.299
ENSG00000151576 E012 49.7169841 0.0133751015 0.2390901146 0.475556343 3 114057022 114057106 85 + 1.687 1.651 -0.124
ENSG00000151576 E013 4.1926522 0.0086918536 0.0032975760 0.025178915 3 114057107 114057548 442 + 0.785 0.297 -2.378
ENSG00000151576 E014 60.0468908 0.0008373840 0.2152707076 0.447818835 3 114065237 114065243 7 + 1.762 1.740 -0.077
ENSG00000151576 E015 72.7087884 0.0006909975 0.5017507245 0.702066002 3 114065244 114065278 35 + 1.815 1.883 0.231
ENSG00000151576 E016 79.4482959 0.0005394887 0.6696828387 0.816093665 3 114065279 114065329 51 + 1.856 1.913 0.191
ENSG00000151576 E017 132.4995819 0.0003271371 0.6955582535 0.832623438 3 114065330 114065457 128 + 2.087 2.114 0.090
ENSG00000151576 E018 74.2319417 0.0005328423 0.0748704017 0.234558616 3 114066228 114066244 17 + 1.858 1.818 -0.136
ENSG00000151576 E019 85.8808543 0.0004469272 0.4643087726 0.676095456 3 114066245 114066283 39 + 1.904 1.913 0.032
ENSG00000151576 E020 3.7056989 0.0082644833 0.0061426461 0.040432658 3 114066284 114066565 282 + 0.753 0.297 -2.251
ENSG00000151576 E021 109.9967583 0.0004118709 0.6239136199 0.786558105 3 114067987 114068063 77 + 2.008 2.029 0.072
ENSG00000151576 E022 5.1359479 0.0062908251 0.0375317158 0.148395813 3 114068064 114068324 261 + 0.828 0.538 -1.226
ENSG00000151576 E023 238.0423832 0.0005662536 0.2229073002 0.456862508 3 114070626 114070838 213 + 2.344 2.350 0.022
ENSG00000151576 E024 180.7322905 0.0003005276 0.1199604944 0.315783053 3 114076743 114076838 96 + 2.230 2.224 -0.017
ENSG00000151576 E025 163.6625862 0.0003503333 0.7516445739 0.867759376 3 114076839 114076942 104 + 2.176 2.206 0.100
ENSG00000151576 E026 50.0965289 0.0476215654 0.1372609946 0.343335453 3 114076943 114079550 2608 + 1.716 1.566 -0.512
ENSG00000151576 E027 5.2841767 0.0049945368 0.3269030175 0.566053032 3 114079867 114079905 39 + 0.800 0.692 -0.435
ENSG00000151576 E028 199.6057867 0.0003510556 0.0013858660 0.012797125 3 114079906 114080057 152 + 2.285 2.237 -0.162
ENSG00000151576 E029 5.1299631 0.0050819863 0.3836281318 0.615256356 3 114082553 114082676 124 + 0.785 0.692 -0.377
ENSG00000151576 E030 160.7044787 0.0002980754 0.0002431617 0.003144328 3 114082677 114082768 92 + 2.198 2.125 -0.243
ENSG00000151576 E031 98.3003504 0.0004513403 0.0001335561 0.001904358 3 114082769 114082794 26 + 1.996 1.884 -0.377
ENSG00000151576 E032 6.6514099 0.0047034947 0.0897458876 0.263322263 3 114082963 114083003 41 + 0.770 1.013 0.930
ENSG00000151576 E033 1723.3034871 0.0040813539 0.0009535227 0.009534272 3 114085673 114088422 2750 + 3.169 3.267 0.325