ENSG00000151502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281187 ENSG00000151502 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS26B protein_coding protein_coding 44.04779 62.14106 32.08075 6.75858 1.055121 -0.9536215 16.105219 26.345944 5.703659 3.1997023 0.2816289 -2.20564151 0.37579167 0.42263333 0.1781333 -0.24450000 3.139699e-12 9.213226e-30 FALSE TRUE
ENST00000525095 ENSG00000151502 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS26B protein_coding protein_coding 44.04779 62.14106 32.08075 6.75858 1.055121 -0.9536215 1.670678 0.000000 6.095191 0.0000000 0.6933840 9.25389255 0.04299583 0.00000000 0.1909667 0.19096667 9.213226e-30 9.213226e-30 FALSE TRUE
ENST00000531741 ENSG00000151502 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS26B protein_coding retained_intron 44.04779 62.14106 32.08075 6.75858 1.055121 -0.9536215 2.321400 2.723296 2.228132 0.4706456 0.1402893 -0.28834668 0.05650000 0.04666667 0.0694000 0.02273333 6.389879e-01 9.213226e-30   FALSE
MSTRG.6595.3 ENSG00000151502 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS26B protein_coding   44.04779 62.14106 32.08075 6.75858 1.055121 -0.9536215 7.233443 7.205456 7.029043 1.6193851 0.2441222 -0.03571122 0.16796667 0.11276667 0.2191667 0.10640000 2.124644e-02 9.213226e-30 FALSE FALSE
MSTRG.6595.5 ENSG00000151502 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS26B protein_coding   44.04779 62.14106 32.08075 6.75858 1.055121 -0.9536215 13.177095 20.801125 7.720611 3.3766467 1.0278505 -1.42870064 0.26975833 0.33050000 0.2391333 -0.09136667 3.424134e-01 9.213226e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151502 E001 6.854294 0.004853404 2.582799e-02 1.147496e-01 11 134224671 134224676 6 + 0.548 0.925 1.548
ENSG00000151502 E002 23.355232 0.001588428 1.223435e-04 1.766579e-03 11 134224677 134224761 85 + 1.026 1.426 1.415
ENSG00000151502 E003 24.693273 0.001640176 3.544113e-06 8.576118e-05 11 134224762 134224799 38 + 0.983 1.461 1.697
ENSG00000151502 E004 161.676535 0.125125615 1.448652e-01 3.547645e-01 11 134224800 134225193 394 + 1.990 2.221 0.773
ENSG00000151502 E005 202.831600 1.189412370 4.999201e-01 7.006735e-01 11 134225194 134225298 105 + 2.131 2.308 0.591
ENSG00000151502 E006 172.666918 1.142067843 5.170581e-01 7.130453e-01 11 134225299 134225345 47 + 2.078 2.234 0.523
ENSG00000151502 E007 177.779915 0.080398577 5.687582e-01 7.493849e-01 11 134234897 134234961 65 + 2.152 2.228 0.255
ENSG00000151502 E008 242.013708 0.004494991 2.836571e-01 5.241102e-01 11 134234962 134235053 92 + 2.338 2.342 0.015
ENSG00000151502 E009 11.053123 0.041302344 9.770306e-01 9.902733e-01 11 134235054 134235707 654 + 1.006 1.047 0.152
ENSG00000151502 E010 16.616368 0.052053790 7.409176e-02 2.329141e-01 11 134236342 134236746 405 + 1.327 1.139 -0.664
ENSG00000151502 E011 11.304203 0.065992881 8.473728e-01 9.235054e-01 11 134239651 134239990 340 + 1.027 1.056 0.106
ENSG00000151502 E012 338.311281 0.001364777 3.965644e-06 9.428218e-05 11 134239991 134240155 165 + 2.533 2.462 -0.238
ENSG00000151502 E013 14.889459 0.002285567 1.059158e-05 2.205092e-04 11 134240465 134240621 157 + 1.377 1.028 -1.239
ENSG00000151502 E014 385.384886 0.002309793 7.374322e-03 4.643244e-02 11 134243119 134243294 176 + 2.561 2.534 -0.091
ENSG00000151502 E015 26.764449 0.103526816 2.378965e-01 4.741482e-01 11 134243427 134243733 307 + 1.475 1.366 -0.377
ENSG00000151502 E016 82.980223 0.059190776 1.441454e-02 7.593747e-02 11 134243852 134244937 1086 + 2.035 1.799 -0.792
ENSG00000151502 E017 323.764734 0.003942076 8.260923e-01 9.115448e-01 11 134244938 134245080 143 + 2.435 2.478 0.142
ENSG00000151502 E018 2249.754948 0.010466319 5.690087e-01 7.495231e-01 11 134245444 134247788 2345 + 3.256 3.326 0.234