ENSG00000151491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281172 ENSG00000151491 HEK293_OSMI2_6hA HEK293_TMG_6hB EPS8 protein_coding protein_coding 5.187604 1.989394 9.362086 0.4014436 0.4862611 2.228808 0.2174602 0.6796870 0.00000000 0.67968696 0.00000000 -6.107870 0.11567917 0.31280000 0.0000000 -0.31280000 0.5389622107 0.0003983893 FALSE TRUE
ENST00000543468 ENSG00000151491 HEK293_OSMI2_6hA HEK293_TMG_6hB EPS8 protein_coding nonsense_mediated_decay 5.187604 1.989394 9.362086 0.4014436 0.4862611 2.228808 0.1011669 0.3919980 0.00000000 0.20155571 0.00000000 -5.329116 0.05588750 0.22500000 0.0000000 -0.22500000 0.0989823784 0.0003983893 FALSE TRUE
ENST00000644374 ENSG00000151491 HEK293_OSMI2_6hA HEK293_TMG_6hB EPS8 protein_coding protein_coding 5.187604 1.989394 9.362086 0.4014436 0.4862611 2.228808 1.0682523 0.0000000 1.85141339 0.00000000 0.49481652 7.540255 0.23197083 0.00000000 0.2044333 0.20443333 0.0003983893 0.0003983893 FALSE TRUE
ENST00000646918 ENSG00000151491 HEK293_OSMI2_6hA HEK293_TMG_6hB EPS8 protein_coding protein_coding 5.187604 1.989394 9.362086 0.4014436 0.4862611 2.228808 0.1199238 0.1274692 0.03291861 0.07662492 0.02135002 -1.679433 0.05301667 0.09123333 0.0033000 -0.08793333 0.2129802634 0.0003983893 FALSE TRUE
ENST00000647224 ENSG00000151491 HEK293_OSMI2_6hA HEK293_TMG_6hB EPS8 protein_coding protein_coding 5.187604 1.989394 9.362086 0.4014436 0.4862611 2.228808 2.7334020 0.6009173 5.72385957 0.60091732 0.67408314 3.230458 0.38617500 0.23340000 0.6078667 0.37446667 0.3286101426 0.0003983893 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151491 E001 0.1614157 0.0348220919 1.000000e+00   12 15620134 15620157 24 - 0.066 0.000 -9.743
ENSG00000151491 E002 0.3751086 0.0394166813 3.151922e-02   12 15620158 15620161 4 - 0.000 0.356 15.509
ENSG00000151491 E003 0.5778428 0.1636329544 1.027229e-02   12 15620162 15620180 19 - 0.000 0.470 15.793
ENSG00000151491 E004 1.1967145 0.0870678461 1.327828e-02   12 15620181 15620190 10 - 0.123 0.624 3.297
ENSG00000151491 E005 1.3994488 0.1752677877 1.026053e-02 0.059227853 12 15620191 15620194 4 - 0.122 0.693 3.597
ENSG00000151491 E006 2.0253350 0.0271650375 3.707995e-04 0.004444857 12 15620195 15620233 39 - 0.174 0.828 3.541
ENSG00000151491 E007 9.6273045 0.2024125947 2.101571e-02 0.099405370 12 15620234 15620348 115 - 0.761 1.315 2.043
ENSG00000151491 E008 11.8817729 0.3250620657 9.378600e-02 0.270781339 12 15620349 15620376 28 - 0.884 1.348 1.675
ENSG00000151491 E009 15.3519246 0.4092784229 1.277386e-01 0.328255150 12 15620377 15620411 35 - 1.002 1.426 1.506
ENSG00000151491 E010 65.5853019 0.9146381384 2.851521e-01 0.525739972 12 15620412 15620982 571 - 1.634 1.988 1.197
ENSG00000151491 E011 33.8358192 0.6737530608 1.962484e-01 0.424862452 12 15620983 15621202 220 - 1.337 1.736 1.369
ENSG00000151491 E012 16.6684105 0.4432581597 1.719958e-01 0.393217010 12 15621203 15621273 71 - 1.061 1.422 1.273
ENSG00000151491 E013 31.9655511 0.2726129368 9.747203e-02 0.277348544 12 15621274 15621430 157 - 1.322 1.700 1.298
ENSG00000151491 E014 27.5702772 0.0261358382 1.404738e-02 0.074521065 12 15623158 15623219 62 - 1.287 1.606 1.101
ENSG00000151491 E015 31.0195860 0.0280265261 3.881551e-01 0.619078874 12 15623220 15623287 68 - 1.381 1.535 0.528
ENSG00000151491 E016 52.1946126 0.0030602618 4.042248e-01 0.631710052 12 15624227 15624407 181 - 1.610 1.743 0.453
ENSG00000151491 E017 57.4374937 0.0008812561 1.663726e-02 0.084111493 12 15631442 15631664 223 - 1.693 1.644 -0.167
ENSG00000151491 E018 0.1779838 0.0571988768 1.000000e+00   12 15631665 15631762 98 - 0.066 0.000 -11.183
ENSG00000151491 E019 0.0000000       12 15634739 15634762 24 -      
ENSG00000151491 E020 36.9009711 0.0071224004 1.077603e-01 0.295330461 12 15640703 15640846 144 - 1.501 1.460 -0.143
ENSG00000151491 E021 37.1252653 0.0072666057 2.967933e-01 0.537321140 12 15641722 15641830 109 - 1.497 1.504 0.023
ENSG00000151491 E022 21.8087829 0.0330140350 3.957264e-01 0.625014897 12 15647127 15647149 23 - 1.280 1.278 -0.008
ENSG00000151491 E023 40.1216158 0.0192767896 5.989766e-01 0.769557618 12 15647150 15647260 111 - 1.524 1.563 0.135
ENSG00000151491 E024 43.8639354 0.0101496029 5.893160e-01 0.763225099 12 15650823 15651006 184 - 1.562 1.607 0.155
ENSG00000151491 E025 33.0695208 0.0014395078 8.077621e-01 0.900883230 12 15654145 15654293 149 - 1.438 1.505 0.229
ENSG00000151491 E026 0.8383617 0.0245541361 4.281544e-01   12 15654294 15654430 137 - 0.174 0.356 1.366
ENSG00000151491 E027 0.6190593 0.0213087141 1.000000e+00   12 15657894 15658075 182 - 0.174 0.213 0.364
ENSG00000151491 E028 0.0000000       12 15658076 15658078 3 -      
ENSG00000151491 E029 18.6117391 0.0041647930 6.187767e-01 0.783009803 12 15658079 15658153 75 - 1.185 1.313 0.453
ENSG00000151491 E030 22.5000240 0.0455753898 7.770730e-01 0.882968044 12 15658497 15658585 89 - 1.275 1.352 0.267
ENSG00000151491 E031 30.8302551 0.0020288385 4.005350e-01 0.628744171 12 15660614 15660740 127 - 1.417 1.440 0.079
ENSG00000151491 E032 29.8487274 0.0013810899 1.446783e-01 0.354449120 12 15662026 15662099 74 - 1.414 1.388 -0.093
ENSG00000151491 E033 0.6268817 0.1235864842 3.611582e-01   12 15662100 15662115 16 - 0.219 0.000 -13.137
ENSG00000151491 E034 0.7687085 0.0178838378 4.316361e-01   12 15662193 15662335 143 - 0.174 0.355 1.360
ENSG00000151491 E035 1.9814591 0.1349063781 5.928356e-01 0.765534642 12 15662336 15662692 357 - 0.427 0.354 -0.408
ENSG00000151491 E036 0.3088520 0.0274072847 4.000523e-01   12 15665023 15665106 84 - 0.066 0.213 1.942
ENSG00000151491 E037 1.3012550 0.0680604203 8.638784e-02   12 15665349 15665755 407 - 0.365 0.000 -14.054
ENSG00000151491 E038 32.4119577 0.0176184593 1.867310e-02 0.091305708 12 15665756 15665892 137 - 1.464 1.326 -0.481
ENSG00000151491 E039 32.2496509 0.0279446243 6.809311e-03 0.043732609 12 15666440 15666522 83 - 1.473 1.256 -0.754
ENSG00000151491 E040 31.8175630 0.0146681653 2.873436e-03 0.022649133 12 15669387 15669465 79 - 1.468 1.257 -0.732
ENSG00000151491 E041 27.6688358 0.0014883507 7.976761e-02 0.244351802 12 15669466 15669518 53 - 1.386 1.328 -0.203
ENSG00000151491 E042 20.3862651 0.0020908184 1.479684e-01 0.359429518 12 15669519 15669536 18 - 1.261 1.209 -0.183
ENSG00000151491 E043 16.9457669 0.0042747258 1.504556e-01 0.362960791 12 15669664 15669667 4 - 1.184 1.115 -0.247
ENSG00000151491 E044 38.2163664 0.0013165075 5.297266e-03 0.036176871 12 15669668 15669825 158 - 1.534 1.420 -0.390
ENSG00000151491 E045 11.5725930 0.0035476027 3.324201e-01 0.571191637 12 15670856 15670858 3 - 1.029 0.994 -0.129
ENSG00000151491 E046 25.1712576 0.0018044700 6.568480e-03 0.042551175 12 15670859 15670923 65 - 1.365 1.209 -0.546
ENSG00000151491 E047 0.1614157 0.0348220919 1.000000e+00   12 15672454 15672504 51 - 0.066 0.000 -11.165
ENSG00000151491 E048 30.9265073 0.0070243723 2.108973e-03 0.017799033 12 15681226 15681302 77 - 1.451 1.258 -0.671
ENSG00000151491 E049 27.2534331 0.0118361266 6.656025e-05 0.001063255 12 15682893 15682972 80 - 1.417 1.072 -1.219
ENSG00000151491 E050 0.4054685 0.4941325364 8.229949e-02   12 15682973 15684168 1196 - 0.000 0.370 14.839
ENSG00000151491 E051 0.0000000       12 15684169 15684196 28 -      
ENSG00000151491 E052 0.0000000       12 15684197 15684302 106 -      
ENSG00000151491 E053 0.1723744 0.0900865482 1.435440e-01   12 15712853 15713265 413 - 0.000 0.213 14.394
ENSG00000151491 E054 0.8102147 0.3630794113 4.796671e-01   12 15713266 15713325 60 - 0.173 0.359 1.393
ENSG00000151491 E055 0.0000000       12 15728129 15728265 137 -      
ENSG00000151491 E056 0.1614157 0.0348220919 1.000000e+00   12 15780579 15780727 149 - 0.066 0.000 -11.165
ENSG00000151491 E057 0.0000000       12 15787963 15788010 48 -      
ENSG00000151491 E058 22.5149882 0.0318097673 1.588797e-02 0.081364956 12 15789161 15789386 226 - 1.322 1.095 -0.806
ENSG00000151491 E059 2.0048044 0.0290657783 1.688307e-01 0.389027701 12 15789387 15789418 32 - 0.449 0.213 -1.514
ENSG00000151491 E060 0.0000000       12 15813493 15813561 69 -      
ENSG00000151491 E061 0.1779838 0.0571988768 1.000000e+00   12 15813562 15813752 191 - 0.066 0.000 -11.183
ENSG00000151491 E062 0.1779838 0.0571988768 1.000000e+00   12 15817048 15817110 63 - 0.066 0.000 -11.183
ENSG00000151491 E063 0.0000000       12 15818053 15818063 11 -      
ENSG00000151491 E064 0.2027342 0.0371857976 1.406510e-01   12 15828181 15828372 192 - 0.000 0.214 14.537
ENSG00000151491 E065 0.2027342 0.0371857976 1.406510e-01   12 15837573 15837724 152 - 0.000 0.214 14.537
ENSG00000151491 E066 1.0351266 0.0180215296 6.082972e-01   12 15881107 15881199 93 - 0.220 0.356 0.947
ENSG00000151491 E067 2.4515660 0.3856802258 2.886710e-02 0.123974599 12 15881780 15882262 483 - 0.217 0.909 3.456
ENSG00000151491 E068 0.3150090 0.0399050350 3.911366e-01   12 15882263 15882329 67 - 0.066 0.213 1.950