ENSG00000151474

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357447 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding protein_coding 2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.6304250 0.6551147 0.4739876 0.09835862 0.06934064 -0.4586333 0.26478333 0.24110000 0.2206333 -0.02046667 1.0000000000 0.0001640703 FALSE TRUE
ENST00000475325 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding retained_intron 2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.5215363 0.8886637 0.5240836 0.47190854 0.36903985 -0.7507158 0.19693750 0.24220000 0.2000333 -0.04216667 0.9735421238 0.0001640703   FALSE
ENST00000632570 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding protein_coding 2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.1536439 0.1531489 0.2488832 0.15314890 0.06548894 0.6661120 0.06709583 0.03653333 0.1339000 0.09736667 0.5179806144 0.0001640703 TRUE TRUE
ENST00000649099 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding protein_coding 2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.3597215 0.4143148 0.5786389 0.41431482 0.57863894 0.4722479 0.09240000 0.09883333 0.1838000 0.08496667 1.0000000000 0.0001640703   FALSE
MSTRG.3573.3 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding   2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.2871624 0.6953563 0.0000000 0.16449196 0.00000000 -6.1402802 0.12510000 0.26870000 0.0000000 -0.26870000 0.0022187459 0.0001640703 FALSE TRUE
MSTRG.3573.5 ENSG00000151474 HEK293_OSMI2_6hA HEK293_TMG_6hB FRMD4A protein_coding   2.569275 3.17953 2.343759 0.6542623 0.5173534 -0.4383774 0.3021663 0.0000000 0.4216049 0.00000000 0.06464798 5.4316393 0.13330833 0.00000000 0.2125333 0.21253333 0.0001640703 0.0001640703 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151474 E001 46.4601941 0.002023792 0.852366984 0.92638395 10 13643706 13646271 2566 - 1.631 1.671 0.138
ENSG00000151474 E002 7.8963465 0.003795128 0.155726317 0.37052583 10 13646272 13646326 55 - 0.793 0.994 0.765
ENSG00000151474 E003 4.7855654 0.006599509 0.253288329 0.49151148 10 13646327 13646333 7 - 0.606 0.798 0.796
ENSG00000151474 E004 4.6546972 0.008105891 0.306561709 0.54721052 10 13646334 13646334 1 - 0.606 0.781 0.730
ENSG00000151474 E005 32.4272663 0.305865216 0.092263935 0.26793902 10 13646335 13647035 701 - 1.229 1.602 1.290
ENSG00000151474 E006 0.1723744 0.035383001 0.939623007   10 13651903 13651974 72 - 0.000 0.093 9.926
ENSG00000151474 E007 8.7448524 0.099864535 0.573324909 0.75253361 10 13654416 13654512 97 - 0.896 1.003 0.401
ENSG00000151474 E008 0.3032425 0.027442404 0.450087542   10 13654513 13654526 14 - 0.000 0.170 10.900
ENSG00000151474 E009 16.6225377 0.002424074 0.056330726 0.19440442 10 13656636 13657261 626 - 1.090 1.289 0.708
ENSG00000151474 E010 13.6804296 0.025575059 0.008382128 0.05107748 10 13657262 13657522 261 - 0.876 1.247 1.352
ENSG00000151474 E011 10.8379510 0.025312875 0.082656073 0.25001453 10 13659323 13659490 168 - 0.876 1.138 0.968
ENSG00000151474 E012 12.1683821 0.022490569 0.470765088 0.68065983 10 13660316 13660553 238 - 1.024 1.147 0.444
ENSG00000151474 E013 4.6506853 0.006063062 0.015073012 0.07835875 10 13663453 13663509 57 - 0.437 0.844 1.783
ENSG00000151474 E014 7.4429073 0.004365538 0.417874471 0.64205175 10 13666097 13666223 127 - 0.823 0.949 0.484
ENSG00000151474 E015 8.4675703 0.004343955 0.989940689 0.99669504 10 13666224 13666325 102 - 0.946 0.972 0.097
ENSG00000151474 E016 11.1365589 0.016554407 0.404737995 0.63209027 10 13670406 13670528 123 - 1.106 1.042 -0.233
ENSG00000151474 E017 13.8615357 0.016214335 0.086345228 0.25710839 10 13674911 13675037 127 - 1.244 1.096 -0.529
ENSG00000151474 E018 5.2988689 0.006971444 0.018703018 0.09140678 10 13675038 13675044 7 - 0.946 0.662 -1.123
ENSG00000151474 E019 0.8509131 0.848607340 0.912290076   10 13684036 13684864 829 - 0.157 0.300 1.188
ENSG00000151474 E020 0.0000000       10 13692169 13693481 1313 -      
ENSG00000151474 E021 1.9645132 0.064301908 0.201509763 0.43155150 10 13693482 13693517 36 - 0.604 0.385 -1.082
ENSG00000151474 E022 0.0000000       10 13693518 13693702 185 -      
ENSG00000151474 E023 0.0000000       10 13693703 13693897 195 -      
ENSG00000151474 E024 9.7821397 0.004440731 0.071685371 0.22818791 10 13693898 13693982 85 - 1.120 0.960 -0.583
ENSG00000151474 E025 9.2190163 0.052729124 0.087489208 0.25909052 10 13693983 13694039 57 - 1.120 0.925 -0.716
ENSG00000151474 E026 11.6635542 0.006832743 0.068749812 0.22225128 10 13701340 13701478 139 - 1.186 1.033 -0.551
ENSG00000151474 E027 7.9140345 0.006988219 0.447999748 0.66424432 10 13707037 13707113 77 - 0.966 0.901 -0.245
ENSG00000151474 E028 3.4712793 0.068924871 0.433992957 0.65420996 10 13707114 13707275 162 - 0.500 0.671 0.770
ENSG00000151474 E029 4.0113878 0.110444260 0.977244684 0.99037326 10 13707276 13707345 70 - 0.650 0.677 0.113
ENSG00000151474 E030 5.8777212 0.184147708 0.664774527 0.81284789 10 13707346 13707757 412 - 0.755 0.846 0.357
ENSG00000151474 E031 7.0412176 0.004194636 0.123418822 0.32116694 10 13737844 13737930 87 - 0.986 0.829 -0.595
ENSG00000151474 E032 5.1980867 0.006657747 0.109148280 0.29769832 10 13740194 13740251 58 - 0.876 0.685 -0.763
ENSG00000151474 E033 6.1451096 0.004845959 0.001073332 0.01047927 10 13740512 13740577 66 - 1.041 0.662 -1.475
ENSG00000151474 E034 5.6667795 0.004964874 0.009164277 0.05454786 10 13747736 13747819 84 - 0.986 0.684 -1.183
ENSG00000151474 E035 0.0000000       10 13753056 13753100 45 -      
ENSG00000151474 E036 0.0000000       10 13759165 13759506 342 -      
ENSG00000151474 E037 2.4578684 0.009126689 0.131017041 0.33340387 10 13761647 13761669 23 - 0.651 0.428 -1.052
ENSG00000151474 E038 2.9977166 0.024988476 0.401674709 0.62973573 10 13762624 13762680 57 - 0.651 0.532 -0.529
ENSG00000151474 E039 2.9679769 0.014936937 0.184305087 0.40957410 10 13782922 13782928 7 - 0.691 0.500 -0.854
ENSG00000151474 E040 3.7833532 0.078751116 0.753209226 0.86866223 10 13782929 13783006 78 - 0.688 0.644 -0.186
ENSG00000151474 E041 8.3726355 0.074552147 0.471829973 0.68141493 10 13796496 13796588 93 - 1.021 0.921 -0.374
ENSG00000151474 E042 8.9728772 0.004303701 0.789152100 0.88995848 10 13810814 13810908 95 - 0.986 0.983 -0.012
ENSG00000151474 E043 6.0650677 0.026463725 0.899911294 0.95184966 10 13858847 13858912 66 - 0.823 0.830 0.026
ENSG00000151474 E044 0.0000000       10 13866261 13866304 44 -      
ENSG00000151474 E045 0.0000000       10 13890479 13890658 180 -      
ENSG00000151474 E046 4.3019581 0.088240723 0.630062195 0.79042644 10 13891624 13891756 133 - 0.762 0.681 -0.333
ENSG00000151474 E047 0.2027342 0.035516598 0.939638299   10 13892245 13892296 52 - 0.000 0.093 9.928
ENSG00000151474 E048 0.0000000       10 13971656 13972369 714 -      
ENSG00000151474 E049 0.8156366 0.016835426 0.240538105   10 14008060 14008533 474 - 0.362 0.170 -1.444
ENSG00000151474 E050 0.0000000       10 14024354 14024375 22 -      
ENSG00000151474 E051 0.1723744 0.035383001 0.939623007   10 14024376 14024547 172 - 0.000 0.093 9.926
ENSG00000151474 E052 0.0000000       10 14082947 14083813 867 -      
ENSG00000151474 E053 0.0000000       10 14097010 14097138 129 -      
ENSG00000151474 E054 0.0000000       10 14174012 14174366 355 -      
ENSG00000151474 E055 0.0000000       10 14326175 14326983 809 -      
ENSG00000151474 E056 0.0000000       10 14330058 14330183 126 -      
ENSG00000151474 E057 0.0000000       10 14330597 14330924 328 -      
ENSG00000151474 E058 0.0000000       10 14388681 14388903 223 -      
ENSG00000151474 E059 0.0000000       10 14462068 14462142 75 -