ENSG00000151465

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281141 ENSG00000151465 HEK293_OSMI2_6hA HEK293_TMG_6hB CDC123 protein_coding protein_coding 120.8508 74.34854 154.1456 18.03679 6.15303 1.051817 108.5241 70.11761 136.332 17.25463 5.826069 0.9591754 0.9062208 0.9408 0.8842 -0.0566 0.0009540857 0.0001403177 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151465 E001 1.3581302 0.044889726 1.982002e-01   10 12195919 12195964 46 + 0.245 0.487 1.450
ENSG00000151465 E002 4.4333968 0.055229555 4.649346e-01 6.765311e-01 10 12195965 12196023 59 + 0.678 0.802 0.505
ENSG00000151465 E003 10.3462337 0.006005764 9.665334e-01 9.851572e-01 10 12196130 12196187 58 + 1.046 1.067 0.078
ENSG00000151465 E004 10.8120096 0.002830191 7.648604e-01 8.755693e-01 10 12196188 12196195 8 + 1.075 1.067 -0.029
ENSG00000151465 E005 106.6445534 0.006941425 7.873631e-01 8.889859e-01 10 12196196 12196222 27 + 2.012 2.047 0.119
ENSG00000151465 E006 135.0398366 0.004046872 1.453241e-01 3.553804e-01 10 12196223 12196231 9 + 2.092 2.180 0.295
ENSG00000151465 E007 430.9960151 0.003596254 4.284050e-01 6.498010e-01 10 12196232 12196319 88 + 2.628 2.625 -0.012
ENSG00000151465 E008 570.1386659 0.003398249 1.459006e-02 7.656052e-02 10 12198705 12198776 72 + 2.768 2.713 -0.183
ENSG00000151465 E009 0.7990684 0.017267182 9.802897e-01   10 12198777 12198876 100 + 0.245 0.260 0.113
ENSG00000151465 E010 644.2552153 0.005019477 7.430165e-02 2.333597e-01 10 12209967 12210024 58 + 2.816 2.773 -0.144
ENSG00000151465 E011 519.2650439 0.005866524 1.254809e-01 3.245982e-01 10 12210290 12210322 33 + 2.721 2.683 -0.124
ENSG00000151465 E012 759.9194233 0.006686083 1.171327e-02 6.529187e-02 10 12215740 12215835 96 + 2.899 2.823 -0.254
ENSG00000151465 E013 608.3385986 0.009710318 2.544611e-02 1.135828e-01 10 12217361 12217413 53 + 2.806 2.719 -0.289
ENSG00000151465 E014 696.7447129 0.006785345 1.006282e-02 5.842984e-02 10 12217414 12217467 54 + 2.863 2.782 -0.267
ENSG00000151465 E015 658.2457103 0.007527242 1.903666e-02 9.259504e-02 10 12230948 12230996 49 + 2.836 2.762 -0.247
ENSG00000151465 E016 741.8680573 0.003561786 1.598691e-02 8.177051e-02 10 12235048 12235123 76 + 2.879 2.831 -0.162
ENSG00000151465 E017 792.6906003 0.007494113 3.363989e-01 5.748220e-01 10 12237144 12237266 123 + 2.869 2.920 0.170
ENSG00000151465 E018 0.1779838 0.058330984 7.570013e-01   10 12237462 12237534 73 + 0.098 0.000 -7.904
ENSG00000151465 E019 426.2786323 0.072489289 1.267827e-01 3.266670e-01 10 12238457 12238485 29 + 2.550 2.712 0.539
ENSG00000151465 E020 4.5521680 0.076973977 2.700529e-02 1.183148e-01 10 12246054 12246148 95 + 0.547 0.926 1.559
ENSG00000151465 E021 692.7633363 1.848371863 4.944864e-01 6.971150e-01 10 12246149 12246277 129 + 2.731 2.951 0.730
ENSG00000151465 E022 678.5539991 0.067629981 5.697929e-02 1.960094e-01 10 12249581 12249718 138 + 2.737 2.928 0.637
ENSG00000151465 E023 8.2172587 0.099013151 4.748723e-01 6.834952e-01 10 12249719 12250310 592 + 0.895 1.026 0.490
ENSG00000151465 E024 409.4843105 0.001205548 2.650406e-08 1.130620e-06 10 12250311 12250589 279 + 2.539 2.695 0.518