ENSG00000151348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343631 ENSG00000151348 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT2 protein_coding protein_coding 36.90164 35.96653 33.17612 3.513937 1.339667 -0.1164761 5.22857 4.906337 5.862528 0.8511949 4.6919431 0.256398015 0.1387583 0.1411000 0.1704667 0.02936667 0.90802374 1.716628e-11 FALSE TRUE
ENST00000682993 ENSG00000151348 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT2 protein_coding nonsense_mediated_decay 36.90164 35.96653 33.17612 3.513937 1.339667 -0.1164761 10.67662 11.803126 6.469974 0.8814710 0.4478477 -0.866330848 0.2880667 0.3299333 0.1967667 -0.13316667 0.02891636 1.716628e-11 TRUE TRUE
MSTRG.5425.10 ENSG00000151348 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT2 protein_coding   36.90164 35.96653 33.17612 3.513937 1.339667 -0.1164761 18.02047 16.953480 16.980924 2.8378717 3.8826286 0.002332166 0.4924708 0.4650333 0.5163667 0.05133333 0.94518248 1.716628e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151348 E001 0.3040503 0.0274424043 1.208209e-01   11 44095648 44095662 15 + 0.249 0.000 -12.355
ENSG00000151348 E002 0.3040503 0.0274424043 1.208209e-01   11 44095663 44095664 2 + 0.249 0.000 -14.426
ENSG00000151348 E003 3.1938613 0.0352732857 9.138266e-01 9.590549e-01 11 44095665 44095677 13 + 0.613 0.600 -0.057
ENSG00000151348 E004 71.0522028 0.0109568407 7.837343e-04 8.143921e-03 11 44095678 44095716 39 + 1.698 1.927 0.773
ENSG00000151348 E005 78.0249256 0.0119091029 2.890564e-03 2.274719e-02 11 44095717 44095723 7 + 1.756 1.960 0.688
ENSG00000151348 E006 155.7689146 0.0013924230 4.100716e-04 4.827737e-03 11 44095724 44095822 99 + 2.108 2.228 0.402
ENSG00000151348 E007 111.1888940 0.0005279968 9.672583e-02 2.759929e-01 11 44095823 44095828 6 + 2.002 2.059 0.192
ENSG00000151348 E008 126.5995379 0.0003319157 1.153275e-01 3.080073e-01 11 44095829 44095852 24 + 2.061 2.111 0.167
ENSG00000151348 E009 3.8878595 0.0788756929 4.773974e-01 6.853036e-01 11 44096225 44096321 97 + 0.612 0.740 0.541
ENSG00000151348 E010 0.7007164 0.5027214646 7.729550e-01   11 44103707 44103745 39 + 0.254 0.190 -0.535
ENSG00000151348 E011 0.3337900 0.0272023517 7.938794e-01   11 44104242 44104616 375 + 0.142 0.104 -0.521
ENSG00000151348 E012 0.1723744 0.0313690047 6.697684e-01   11 44104617 44104783 167 + 0.000 0.104 12.078
ENSG00000151348 E013 2.1698810 0.3119850771 9.089087e-01 9.565199e-01 11 44104784 44106628 1845 + 0.409 0.541 0.662
ENSG00000151348 E014 0.5171231 0.6061413607 3.868039e-01   11 44106629 44106772 144 + 0.000 0.263 12.517
ENSG00000151348 E015 0.7198573 0.1103468848 1.004258e-01   11 44107296 44107682 387 + 0.000 0.321 13.502
ENSG00000151348 E016 104.7889509 0.0003615968 2.121077e-01 4.442402e-01 11 44107683 44107685 3 + 1.983 2.026 0.145
ENSG00000151348 E017 505.5333895 0.0020993572 2.008152e-02 9.617057e-02 11 44107686 44108014 329 + 2.727 2.671 -0.184
ENSG00000151348 E018 524.8809299 0.0010423802 1.880270e-07 6.528585e-06 11 44108015 44108248 234 + 2.770 2.663 -0.355
ENSG00000151348 E019 318.8854196 0.0003766761 2.903294e-03 2.282092e-02 11 44109194 44109283 90 + 2.529 2.465 -0.215
ENSG00000151348 E020 357.3218996 0.0002121756 6.351864e-02 2.106328e-01 11 44114185 44114301 117 + 2.562 2.525 -0.125
ENSG00000151348 E021 5.6584914 0.0386407602 7.293386e-01 8.538680e-01 11 44115901 44116839 939 + 0.778 0.828 0.195
ENSG00000151348 E022 408.9130240 0.0002618036 7.046397e-01 8.385034e-01 11 44124789 44124984 196 + 2.603 2.595 -0.025
ENSG00000151348 E023 285.5802351 0.0017424230 8.821287e-01 9.424175e-01 11 44126816 44126902 87 + 2.444 2.442 -0.004
ENSG00000151348 E024 210.6196576 0.0010209921 2.441520e-01 4.812319e-01 11 44126903 44126955 53 + 2.330 2.297 -0.110
ENSG00000151348 E025 1.2608935 0.0136968632 8.375207e-01   11 44130043 44130044 2 + 0.334 0.370 0.214
ENSG00000151348 E026 263.2143158 0.0001810942 2.849912e-02 1.228065e-01 11 44130045 44130138 94 + 2.437 2.386 -0.169
ENSG00000151348 E027 1.7974178 0.0108647759 7.511001e-01 8.674433e-01 11 44130139 44130644 506 + 0.406 0.460 0.286
ENSG00000151348 E028 1.4700451 0.0116290252 1.297939e-01 3.315234e-01 11 44144247 44144339 93 + 0.521 0.257 -1.522
ENSG00000151348 E029 238.8755007 0.0004574639 9.869225e-01 9.953035e-01 11 44171611 44171673 63 + 2.366 2.365 -0.002
ENSG00000151348 E030 231.6227492 0.0002205853 7.303207e-01 8.544273e-01 11 44171674 44171742 69 + 2.347 2.354 0.023
ENSG00000151348 E031 0.0000000       11 44171743 44171911 169 +      
ENSG00000151348 E032 0.3150090 0.0264368815 7.950013e-01   11 44187361 44187450 90 + 0.142 0.104 -0.519
ENSG00000151348 E033 0.0000000       11 44192126 44192267 142 +      
ENSG00000151348 E034 0.1308682 0.0328997248 6.693845e-01   11 44192713 44192845 133 + 0.000 0.103 12.051
ENSG00000151348 E035 390.9487512 0.0014941050 7.618017e-01 8.737187e-01 11 44197829 44198018 190 + 2.575 2.585 0.031
ENSG00000151348 E036 0.0000000       11 44198019 44198120 102 +      
ENSG00000151348 E037 1.5290471 0.0126616508 2.403142e-01 4.769409e-01 11 44204983 44206792 1810 + 0.521 0.317 -1.110
ENSG00000151348 E038 287.6013739 0.0010522282 4.890713e-01 6.933894e-01 11 44206793 44206864 72 + 2.454 2.438 -0.054
ENSG00000151348 E039 301.5376054 0.0005081907 7.905503e-01 8.908254e-01 11 44206865 44206959 95 + 2.469 2.463 -0.020
ENSG00000151348 E040 2.0338359 0.0800549713 3.203318e-01 5.599962e-01 11 44230343 44232352 2010 + 0.334 0.539 1.090
ENSG00000151348 E041 383.3935021 0.0001546347 1.971740e-01 4.260625e-01 11 44232353 44232496 144 + 2.555 2.578 0.076
ENSG00000151348 E042 385.3342122 0.0002411650 8.008651e-01 8.967773e-01 11 44234115 44234243 129 + 2.571 2.574 0.013
ENSG00000151348 E043 349.1538648 0.0002191245 8.736586e-01 9.379963e-01 11 44236293 44236375 83 + 2.531 2.532 0.006
ENSG00000151348 E044 2.9695696 0.0085168277 7.813123e-01 8.854745e-01 11 44236376 44237890 1515 + 0.612 0.568 -0.198
ENSG00000151348 E045 1220.0698301 0.0004865653 3.322254e-01 5.710419e-01 11 44244149 44245988 1840 + 3.065 3.081 0.052
ENSG00000151348 E046 217.5168487 0.0029889794 3.347659e-08 1.391360e-06 11 44245989 44251464 5476 + 2.195 2.399 0.680
ENSG00000151348 E047 37.3998136 0.0194815423 1.735744e-05 3.386595e-04 11 44251465 44251962 498 + 1.283 1.694 1.413