ENSG00000151208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372391 ENSG00000151208 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG5 protein_coding protein_coding 17.89269 25.84321 13.13126 1.676624 0.3444333 -0.97624 8.939185 12.39530 8.057353 0.7807313 0.03144758 -0.6207896 0.5209917 0.4799 0.6145000 0.1346000 0.025073515 0.001198743 FALSE TRUE
ENST00000424842 ENSG00000151208 HEK293_OSMI2_6hA HEK293_TMG_6hB DLG5 protein_coding protein_coding 17.89269 25.84321 13.13126 1.676624 0.3444333 -0.97624 7.062905 11.25398 2.709732 1.3662296 0.35124314 -2.0501804 0.3627083 0.4323 0.2052667 -0.2270333 0.001198743 0.001198743 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151208 E001 557.6237056 1.4747579562 3.638245e-01 5.989140e-01 10 77790791 77791708 918 - 2.443 2.803 1.199
ENSG00000151208 E002 218.6109737 1.1876360014 4.049123e-01 6.321954e-01 10 77791709 77791900 192 - 2.112 2.380 0.897
ENSG00000151208 E003 251.2951993 1.2447585032 4.168237e-01 6.412385e-01 10 77791901 77792195 295 - 2.175 2.440 0.884
ENSG00000151208 E004 230.9031855 1.2243647221 4.317309e-01 6.525378e-01 10 77792196 77792543 348 - 2.153 2.400 0.823
ENSG00000151208 E005 4.3602631 0.1038513301 5.665230e-01 7.476732e-01 10 77793544 77794007 464 - 0.578 0.757 0.761
ENSG00000151208 E006 170.5010081 0.0003449091 1.323191e-01 3.354557e-01 10 77794008 77794117 110 - 2.138 2.233 0.319
ENSG00000151208 E007 171.6309069 0.0007938554 4.131470e-01 6.384752e-01 10 77794849 77794958 110 - 2.154 2.230 0.255
ENSG00000151208 E008 172.0833626 0.0043091018 7.377359e-01 8.590899e-01 10 77796061 77796188 128 - 2.161 2.227 0.222
ENSG00000151208 E009 155.9421131 0.0019734200 1.495818e-01 3.616475e-01 10 77796451 77796594 144 - 2.093 2.198 0.352
ENSG00000151208 E010 189.9404049 0.0002771448 3.095915e-01 5.500580e-01 10 77805665 77805861 197 - 2.197 2.277 0.266
ENSG00000151208 E011 1.4880183 0.0134550079 3.643314e-01 5.992721e-01 10 77805862 77805928 67 - 0.457 0.326 -0.739
ENSG00000151208 E012 1.5298844 0.0287311680 6.055293e-01 7.738656e-01 10 77806105 77806171 67 - 0.286 0.410 0.757
ENSG00000151208 E013 104.8367365 0.0033420389 9.399641e-01 9.722136e-01 10 77806758 77806795 38 - 1.957 2.014 0.192
ENSG00000151208 E014 179.3696279 0.0003452115 1.253935e-01 3.244557e-01 10 77806796 77806928 133 - 2.160 2.256 0.321
ENSG00000151208 E015 185.8512642 0.0020485198 2.730066e-01 5.128345e-01 10 77807796 77807936 141 - 2.179 2.270 0.304
ENSG00000151208 E016 93.8745017 0.0038803903 8.352260e-01 9.166559e-01 10 77807937 77807944 8 - 1.906 1.970 0.214
ENSG00000151208 E017 0.8148287 0.0170383675 6.265493e-01   10 77807945 77807977 33 - 0.166 0.277 0.939
ENSG00000151208 E018 189.9600873 0.0020053479 9.019774e-01 9.528983e-01 10 77809547 77809730 184 - 2.219 2.267 0.160
ENSG00000151208 E019 135.5817544 0.0003225960 5.528978e-01 7.382998e-01 10 77811094 77811234 141 - 2.057 2.127 0.234
ENSG00000151208 E020 121.6772255 0.0003986883 7.485465e-01 8.658308e-01 10 77811924 77812057 134 - 2.036 2.075 0.131
ENSG00000151208 E021 146.7492436 0.0108131585 5.187404e-01 7.141975e-01 10 77812215 77812377 163 - 2.129 2.145 0.055
ENSG00000151208 E022 2.0667888 0.0159635219 9.408344e-01 9.726766e-01 10 77816033 77816175 143 - 0.457 0.478 0.106
ENSG00000151208 E023 151.8737706 0.0176581469 2.055977e-01 4.365604e-01 10 77816551 77816701 151 - 2.178 2.143 -0.117
ENSG00000151208 E024 106.8195479 0.0120044257 1.091910e-02 6.202344e-02 10 77817007 77817096 90 - 2.073 1.968 -0.352
ENSG00000151208 E025 92.6594736 0.0079835523 5.173734e-01 7.132392e-01 10 77817777 77817889 113 - 1.931 1.948 0.057
ENSG00000151208 E026 99.1913881 0.0050877256 5.838297e-01 7.594963e-01 10 77819321 77819465 145 - 1.953 1.975 0.073
ENSG00000151208 E027 3.3797377 0.0100810538 3.793943e-02 1.494615e-01 10 77819466 77819476 11 - 0.787 0.510 -1.196
ENSG00000151208 E028 12.9707390 0.0946866644 1.569961e-01 3.722536e-01 10 77819477 77819894 418 - 1.217 1.061 -0.561
ENSG00000151208 E029 95.8524300 0.0005265554 2.523009e-01 4.903813e-01 10 77819895 77820018 124 - 1.952 1.956 0.016
ENSG00000151208 E030 33.4679768 0.1002207773 8.870709e-02 2.614094e-01 10 77820019 77821081 1063 - 1.623 1.439 -0.633
ENSG00000151208 E031 266.3114765 0.0012733062 2.523394e-01 4.903991e-01 10 77821082 77821781 700 - 2.384 2.404 0.065
ENSG00000151208 E032 172.3243809 0.0016268683 9.040779e-01 9.539484e-01 10 77821782 77822101 320 - 2.169 2.225 0.187
ENSG00000151208 E033 89.9297298 0.0005670346 6.478109e-01 8.020897e-01 10 77824384 77824476 93 - 1.906 1.938 0.105
ENSG00000151208 E034 0.1426347 0.0312839677 2.065248e-01   10 77824477 77824730 254 - 0.166 0.000 -9.917
ENSG00000151208 E035 107.1635516 0.0019198538 7.860093e-03 4.867714e-02 10 77828882 77828985 104 - 2.046 1.988 -0.194
ENSG00000151208 E036 157.8822143 0.0008566591 4.445190e-06 1.039801e-04 10 77829355 77829530 176 - 2.234 2.139 -0.319
ENSG00000151208 E037 151.2586937 0.0006533586 1.672853e-07 5.890605e-06 10 77830217 77830344 128 - 2.229 2.115 -0.381
ENSG00000151208 E038 147.9616625 0.0003416086 3.927571e-06 9.356036e-05 10 77830741 77830873 133 - 2.205 2.113 -0.307
ENSG00000151208 E039 130.7497356 0.0024998994 1.755210e-02 8.746845e-02 10 77833914 77834039 126 - 2.119 2.076 -0.142
ENSG00000151208 E040 161.5034269 0.0079278370 7.104818e-03 4.510342e-02 10 77835738 77835922 185 - 2.236 2.153 -0.277
ENSG00000151208 E041 186.5638223 0.0002948578 8.600386e-08 3.244210e-06 10 77841881 77842193 313 - 2.308 2.211 -0.323
ENSG00000151208 E042 141.3915455 0.0004772201 8.275844e-08 3.135718e-06 10 77843447 77843706 260 - 2.201 2.081 -0.403
ENSG00000151208 E043 1.4858054 0.0427513658 3.768785e-01 6.097479e-01 10 77845211 77845437 227 - 0.458 0.326 -0.742
ENSG00000151208 E044 115.0647865 0.0114567715 1.453082e-03 1.328918e-02 10 77853354 77853537 184 - 2.125 1.983 -0.474
ENSG00000151208 E045 91.4867719 0.0008848905 1.043221e-05 2.175379e-04 10 77854227 77854358 132 - 2.019 1.893 -0.423
ENSG00000151208 E046 34.2174509 0.0117475745 2.277991e-03 1.890915e-02 10 77854359 77854370 12 - 1.638 1.452 -0.634
ENSG00000151208 E047 74.0077149 0.0041129513 2.140966e-04 2.831233e-03 10 77856730 77856892 163 - 1.941 1.799 -0.479
ENSG00000151208 E048 0.0000000       10 77869099 77869128 30 -      
ENSG00000151208 E049 34.9944349 0.4788642462 7.276201e-01 8.528175e-01 10 77869129 77869197 69 - 1.540 1.522 -0.061
ENSG00000151208 E050 0.0000000       10 77889429 77889507 79 -      
ENSG00000151208 E051 50.6037790 0.0541148479 3.189425e-01 5.586717e-01 10 77926217 77926935 719 - 1.583 1.726 0.488