ENSG00000151148

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342494 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding protein_coding 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 7.553270 9.5475648 7.8311836 1.0239513 0.31519763 -0.2855716 0.35984167 0.39870000 0.39396667 -0.004733333 1.000000e+00 8.266474e-24 FALSE TRUE
ENST00000434735 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding protein_coding 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.069910 1.5235891 0.4235517 0.3009710 0.29802458 -1.8226359 0.05104167 0.06253333 0.02126667 -0.041266667 3.049525e-01 8.266474e-24 FALSE TRUE
ENST00000536398 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding protein_coding 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.263414 0.8309024 1.0716496 0.4634677 0.56553319 0.3632229 0.06038750 0.03196667 0.05643333 0.024466667 9.688916e-01 8.266474e-24 FALSE TRUE
ENST00000539599 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding protein_coding 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.055513 0.0000000 2.0854927 0.0000000 0.13656057 7.7111457 0.05300833 0.00000000 0.10466667 0.104666667 8.266474e-24 8.266474e-24 FALSE TRUE
ENST00000539843 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding retained_intron 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 2.827394 1.1605629 4.2932543 0.6995059 0.97329540 1.8782257 0.13099167 0.04433333 0.21160000 0.167266667 4.190279e-01 8.266474e-24 TRUE FALSE
ENST00000605142 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding protein_coding 20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.651813 2.1530711 1.6525908 0.4054336 0.04137196 -0.3796480 0.07836250 0.09033333 0.08386667 -0.006466667 9.704897e-01 8.266474e-24 FALSE TRUE
MSTRG.7983.2 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding   20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.626584 2.3448003 0.7176668 0.4726737 0.35891091 -1.6942549 0.08036250 0.10196667 0.03650000 -0.065466667 6.489166e-01 8.266474e-24 FALSE TRUE
MSTRG.7983.6 ENSG00000151148 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE3B protein_coding   20.96658 23.90719 19.93566 1.977865 1.265393 -0.261973 1.527387 3.3864926 0.0000000 0.7325489 0.00000000 -8.4079019 0.07120000 0.14540000 0.00000000 -0.145400000 5.345118e-11 8.266474e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151148 E001 5.342156 0.0597046791 3.607893e-01 5.962658e-01 12 109477402 109477627 226 + 0.651 0.823 0.701
ENSG00000151148 E002 3.161277 0.0080210599 6.333070e-01 7.925286e-01 12 109477628 109477633 6 + 0.557 0.638 0.358
ENSG00000151148 E003 3.161277 0.0080210599 6.333070e-01 7.925286e-01 12 109477634 109477634 1 + 0.557 0.638 0.358
ENSG00000151148 E004 3.648661 0.0068873879 6.389675e-01 7.962371e-01 12 109477635 109477637 3 + 0.607 0.684 0.330
ENSG00000151148 E005 18.556039 0.0073374806 5.202385e-01 7.151237e-01 12 109477638 109477651 14 + 1.295 1.245 -0.178
ENSG00000151148 E006 22.419683 0.0177909696 9.668563e-01 9.853155e-01 12 109477652 109477652 1 + 1.342 1.346 0.012
ENSG00000151148 E007 27.894608 0.0154319879 3.088236e-01 5.493345e-01 12 109477653 109477654 2 + 1.368 1.468 0.348
ENSG00000151148 E008 70.765482 0.0088486335 6.451648e-01 8.003143e-01 12 109477655 109477764 110 + 1.808 1.845 0.126
ENSG00000151148 E009 24.561902 0.0026371441 8.629519e-01 9.319733e-01 12 109477765 109477776 12 + 1.365 1.385 0.068
ENSG00000151148 E010 103.722107 0.0005177120 1.490656e-01 3.609153e-01 12 109477777 109478109 333 + 2.023 1.976 -0.156
ENSG00000151148 E011 109.166028 0.0004041816 1.243453e-05 2.533192e-04 12 109481637 109481742 106 + 2.106 1.959 -0.490
ENSG00000151148 E012 171.114676 0.0048159640 3.093594e-04 3.825555e-03 12 109483531 109483712 182 + 2.301 2.157 -0.480
ENSG00000151148 E013 141.894323 0.0018777411 2.203454e-07 7.509477e-06 12 109483861 109483981 121 + 2.237 2.059 -0.595
ENSG00000151148 E014 0.000000       12 109483982 109484021 40 +      
ENSG00000151148 E015 94.665751 0.0004447079 8.404980e-09 4.017334e-07 12 109486012 109486071 60 + 2.080 1.872 -0.696
ENSG00000151148 E016 125.741442 0.0050192054 6.890926e-04 7.347509e-03 12 109486471 109486575 105 + 2.168 2.021 -0.493
ENSG00000151148 E017 140.704379 0.0035817130 1.475907e-03 1.344868e-02 12 109488572 109488668 97 + 2.203 2.081 -0.409
ENSG00000151148 E018 119.017446 0.0048316027 9.432438e-02 2.717709e-01 12 109489919 109490004 86 + 2.098 2.029 -0.230
ENSG00000151148 E019 53.518416 0.0007914883 9.789256e-01 9.912449e-01 12 109490005 109490489 485 + 1.708 1.712 0.016
ENSG00000151148 E020 29.968277 0.0015169010 6.563597e-01 8.075676e-01 12 109490490 109491044 555 + 1.479 1.456 -0.081
ENSG00000151148 E021 66.636529 0.0009328948 1.255741e-01 3.247453e-01 12 109491045 109491127 83 + 1.844 1.780 -0.216
ENSG00000151148 E022 1.980514 0.6780739539 9.331708e-01 9.687614e-01 12 109491128 109492737 1610 + 0.485 0.447 -0.194
ENSG00000151148 E023 90.712082 0.0005295737 1.336814e-01 3.375788e-01 12 109497818 109497923 106 + 1.972 1.920 -0.174
ENSG00000151148 E024 109.623819 0.0010704238 8.095084e-03 4.976583e-02 12 109498233 109498353 121 + 2.075 1.984 -0.306
ENSG00000151148 E025 112.578282 0.0003603876 5.063454e-01 7.051697e-01 12 109499633 109499810 178 + 2.044 2.027 -0.057
ENSG00000151148 E026 68.450838 0.0005427643 4.277824e-01 6.493323e-01 12 109501371 109501424 54 + 1.835 1.806 -0.098
ENSG00000151148 E027 86.894221 0.0007767878 6.747353e-02 2.193940e-01 12 109501425 109501534 110 + 1.961 1.893 -0.228
ENSG00000151148 E028 124.447617 0.0003566054 2.396545e-01 4.762661e-01 12 109503023 109503190 168 + 2.094 2.061 -0.110
ENSG00000151148 E029 138.126721 0.0004606034 9.377516e-01 9.711186e-01 12 109507564 109507735 172 + 2.115 2.124 0.030
ENSG00000151148 E030 20.968351 0.0594189597 2.128150e-01 4.450436e-01 12 109508450 109509595 1146 + 1.408 1.262 -0.511
ENSG00000151148 E031 100.290547 0.0021665499 1.000197e-01 2.818306e-01 12 109509596 109509714 119 + 1.931 2.009 0.261
ENSG00000151148 E032 85.015704 0.0005566583 1.020593e-01 2.854600e-01 12 109510344 109510458 115 + 1.864 1.938 0.247
ENSG00000151148 E033 100.755417 0.0005038004 7.477847e-01 8.653563e-01 12 109511204 109511303 100 + 1.989 1.984 -0.019
ENSG00000151148 E034 0.000000       12 109511304 109511315 12 +      
ENSG00000151148 E035 108.469312 0.0008361158 5.256156e-01 7.189311e-01 12 109516765 109516884 120 + 2.026 2.010 -0.055
ENSG00000151148 E036 3.643716 0.1377979096 3.630680e-01 5.982105e-01 12 109517917 109518013 97 + 0.501 0.710 0.927
ENSG00000151148 E037 1.671899 0.1470026653 4.261113e-01 6.480927e-01 12 109519556 109521147 1592 + 0.271 0.469 1.168
ENSG00000151148 E038 146.337839 0.0023677251 4.782033e-01 6.859318e-01 12 109521148 109521324 177 + 2.120 2.157 0.124
ENSG00000151148 E039 110.715592 0.0005064022 6.531076e-01 8.054603e-01 12 109521441 109521551 111 + 2.008 2.031 0.076
ENSG00000151148 E040 112.727872 0.0004690233 1.840286e-01 4.091793e-01 12 109523978 109524115 138 + 1.997 2.051 0.181
ENSG00000151148 E041 98.757073 0.0051253291 3.304232e-01 5.693677e-01 12 109524438 109524503 66 + 1.940 1.997 0.190
ENSG00000151148 E042 96.559609 0.0008075234 5.520825e-01 7.377681e-01 12 109526358 109526416 59 + 1.947 1.976 0.099
ENSG00000151148 E043 2.575902 0.0085569685 4.263903e-02 1.616336e-01 12 109526417 109526433 17 + 0.272 0.638 1.944
ENSG00000151148 E044 53.349225 0.0006790186 6.870429e-01 8.271911e-01 12 109529890 109529895 6 + 1.722 1.708 -0.049
ENSG00000151148 E045 73.784202 0.0005544966 5.606956e-01 7.437485e-01 12 109529896 109529929 34 + 1.827 1.858 0.106
ENSG00000151148 E046 135.919780 0.0006073827 1.704034e-02 8.561407e-02 12 109529930 109530072 143 + 2.051 2.138 0.292
ENSG00000151148 E047 116.266468 0.0065336933 1.146649e-01 3.068989e-01 12 109530547 109530658 112 + 1.987 2.076 0.298
ENSG00000151148 E048 91.249724 0.0005400878 1.102176e-04 1.621685e-03 12 109533466 109533558 93 + 1.827 1.991 0.554
ENSG00000151148 E049 24.200581 0.0353719909 7.833100e-01 8.865859e-01 12 109533657 109533947 291 + 1.347 1.398 0.178
ENSG00000151148 E050 69.527841 0.0030440812 4.783303e-01 6.859666e-01 12 109533948 109534590 643 + 1.795 1.840 0.154
ENSG00000151148 E051 817.580550 0.0012434216 4.838590e-16 8.462449e-14 12 109534591 109536705 2115 + 2.777 2.943 0.549