ENSG00000151116

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300038 ENSG00000151116 HEK293_OSMI2_6hA HEK293_TMG_6hB UEVLD protein_coding protein_coding 5.076533 1.83998 7.676751 0.2816747 0.2305559 2.054865 1.4138471 0.90026436 1.0997698 0.04950215 0.11129879 0.2859029 0.36202500 0.5064667 0.14443333 -0.36203333 6.807393e-05 1.208047e-06 FALSE TRUE
ENST00000396196 ENSG00000151116 HEK293_OSMI2_6hA HEK293_TMG_6hB UEVLD protein_coding nonsense_mediated_decay 5.076533 1.83998 7.676751 0.2816747 0.2305559 2.054865 0.4188973 0.09832268 1.1225859 0.09832268 0.29860175 3.3862132 0.06190000 0.0510000 0.14886667 0.09786667 5.060807e-01 1.208047e-06 FALSE TRUE
ENST00000396197 ENSG00000151116 HEK293_OSMI2_6hA HEK293_TMG_6hB UEVLD protein_coding protein_coding 5.076533 1.83998 7.676751 0.2816747 0.2305559 2.054865 1.6400797 0.49413307 2.7291097 0.08310708 0.16373172 2.4418305 0.29967083 0.2680667 0.35496667 0.08690000 5.284316e-01 1.208047e-06 FALSE TRUE
ENST00000540917 ENSG00000151116 HEK293_OSMI2_6hA HEK293_TMG_6hB UEVLD protein_coding processed_transcript 5.076533 1.83998 7.676751 0.2816747 0.2305559 2.054865 0.3100089 0.07315099 0.5621979 0.07315099 0.29353331 2.7827088 0.06006667 0.0321000 0.07123333 0.03913333 8.441127e-01 1.208047e-06 FALSE FALSE
ENST00000543987 ENSG00000151116 HEK293_OSMI2_6hA HEK293_TMG_6hB UEVLD protein_coding protein_coding 5.076533 1.83998 7.676751 0.2816747 0.2305559 2.054865 0.4301533 0.00000000 1.1629919 0.00000000 0.06316587 6.8740493 0.05579167 0.0000000 0.15153333 0.15153333 1.208047e-06 1.208047e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000151116 E001 58.4851330 0.0008527656 9.126790e-01 9.584424e-01 11 18529609 18531200 1592 - 1.671 1.668 -0.013
ENSG00000151116 E002 34.4655949 0.0010808261 2.729117e-01 5.127365e-01 11 18531201 18531676 476 - 1.463 1.382 -0.277
ENSG00000151116 E003 5.8722789 0.0050074837 4.293948e-01 6.505817e-01 11 18531677 18531697 21 - 0.770 0.643 -0.526
ENSG00000151116 E004 9.2490754 0.0066254484 9.113228e-01 9.578614e-01 11 18531698 18531778 81 - 0.913 0.929 0.061
ENSG00000151116 E005 10.1351748 0.0591905951 9.413833e-01 9.728861e-01 11 18531779 18531873 95 - 0.953 0.962 0.032
ENSG00000151116 E006 30.3162120 0.0012071891 9.780893e-01 9.908069e-01 11 18531874 18532280 407 - 1.390 1.395 0.014
ENSG00000151116 E007 21.2385857 0.0015687710 4.469035e-01 6.633729e-01 11 18532281 18532384 104 - 1.232 1.302 0.244
ENSG00000151116 E008 15.7182282 0.0034923370 6.760086e-01 8.202063e-01 11 18532385 18532405 21 - 1.117 1.164 0.166
ENSG00000151116 E009 21.4488526 0.0016176655 8.141410e-01 9.047236e-01 11 18532406 18532487 82 - 1.248 1.271 0.083
ENSG00000151116 E010 18.5938660 0.0021555862 9.132957e-01 9.587314e-01 11 18534330 18534453 124 - 1.191 1.203 0.042
ENSG00000151116 E011 15.9233008 0.0084617550 1.590729e-01 3.753697e-01 11 18536406 18536469 64 - 1.160 0.992 -0.607
ENSG00000151116 E012 0.4397201 0.0732723595 7.811429e-02   11 18536470 18536764 295 - 0.062 0.370 3.133
ENSG00000151116 E013 29.4743403 0.0013689500 2.034070e-03 1.728715e-02 11 18544623 18544796 174 - 1.422 1.144 -0.975
ENSG00000151116 E014 27.6458499 0.0012834497 2.355463e-02 1.077121e-01 11 18546880 18547050 171 - 1.385 1.184 -0.704
ENSG00000151116 E015 21.5281834 0.0016248010 1.591141e-03 1.426073e-02 11 18558228 18558330 103 - 1.301 0.962 -1.219
ENSG00000151116 E016 8.1400777 0.0040123586 5.810429e-09 2.869278e-07 11 18563646 18564001 356 - 0.640 1.302 2.498
ENSG00000151116 E017 15.0878461 0.0068330102 9.150880e-01 9.596983e-01 11 18564892 18564894 3 - 1.108 1.098 -0.034
ENSG00000151116 E018 31.0596995 0.0058266534 7.764621e-01 8.825928e-01 11 18564895 18565010 116 - 1.404 1.382 -0.077
ENSG00000151116 E019 28.6479741 0.0012476682 6.992460e-01 8.350996e-01 11 18566347 18566482 136 - 1.362 1.394 0.111
ENSG00000151116 E020 1.9377240 0.0921704043 5.833973e-01 7.592481e-01 11 18569898 18570213 316 - 0.376 0.484 0.570
ENSG00000151116 E021 30.6139304 0.0147274545 4.826052e-01 6.888010e-01 11 18570214 18570344 131 - 1.381 1.444 0.217
ENSG00000151116 E022 18.1639078 0.0021468575 4.524611e-01 6.674974e-01 11 18570345 18570377 33 - 1.165 1.239 0.262
ENSG00000151116 E023 0.1426347 0.0318077651 1.000000e+00   11 18570621 18570738 118 - 0.062 0.001 -6.329
ENSG00000151116 E024 24.4193550 0.0014654697 4.140341e-01 6.390275e-01 11 18575347 18575412 66 - 1.287 1.357 0.245
ENSG00000151116 E025 21.7958460 0.0018046457 1.915944e-01 4.188935e-01 11 18578724 18578808 85 - 1.229 1.344 0.405
ENSG00000151116 E026 0.0000000       11 18579428 18579518 91 -      
ENSG00000151116 E027 0.0000000       11 18587677 18587795 119 -      
ENSG00000151116 E028 16.4166301 0.0023535123 4.887061e-02 1.769365e-01 11 18588613 18588747 135 - 1.096 1.287 0.676