ENSG00000150995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357086 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding protein_coding 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.57139435 0.4244415 0.9413102 0.1734953 0.3377983 1.130754 0.22002083 0.15956667 0.24426667 0.08470000 8.814220e-01 8.648857e-08 FALSE TRUE
ENST00000456211 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding protein_coding 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.59706215 0.2697536 1.3635357 0.1512154 0.1144269 2.295666 0.22045833 0.14816667 0.34956667 0.20140000 5.939992e-01 8.648857e-08 FALSE TRUE
ENST00000467545 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding retained_intron 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.21546519 0.2400274 0.2173242 0.2400274 0.2173242 -0.137335 0.09047083 0.08843333 0.05410000 -0.03433333 9.786405e-01 8.648857e-08 FALSE TRUE
ENST00000472205 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding retained_intron 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.07124656 0.0000000 0.5699725 0.0000000 0.2849997 5.857913 0.01857500 0.00000000 0.14860000 0.14860000 3.674180e-01 8.648857e-08 FALSE FALSE
ENST00000478515 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding protein_coding 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.20876387 0.0000000 0.2291184 0.0000000 0.2291184 4.579653 0.05883333 0.00000000 0.05703333 0.05703333 9.296232e-01 8.648857e-08 FALSE FALSE
ENST00000648038 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding protein_coding 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.04023014 0.1408837 0.0000000 0.0908983 0.0000000 -3.915365 0.02124167 0.07096667 0.00000000 -0.07096667 2.536751e-01 8.648857e-08 FALSE TRUE
ENST00000649144 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding retained_intron 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.20157869 0.5568536 0.0000000 0.2342352 0.0000000 -5.824904 0.08370000 0.21813333 0.00000000 -0.21813333 8.648857e-08 8.648857e-08 FALSE TRUE
ENST00000649908 ENSG00000150995 HEK293_OSMI2_6hA HEK293_TMG_6hB ITPR1 protein_coding protein_coding 2.626735 2.532083 3.895918 0.7584647 0.06062798 0.6196508 0.08908087 0.4464995 0.0000000 0.4464995 0.0000000 -5.512541 0.02909167 0.11923333 0.00000000 -0.11923333 8.151258e-01 8.648857e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000150995 E001 0.0000000       3 4493345 4493347 3 +      
ENSG00000150995 E002 0.0000000       3 4493348 4493349 2 +      
ENSG00000150995 E003 0.1426347 0.031893451 0.7962012713   3 4493350 4493451 102 + 0.096 0.000 -10.891
ENSG00000150995 E004 0.1426347 0.031893451 0.7962012713   3 4493452 4493452 1 + 0.096 0.000 -13.073
ENSG00000150995 E005 0.3206185 0.027442404 0.3820247062   3 4493453 4493453 1 + 0.175 0.000 -14.035
ENSG00000150995 E006 3.9609477 0.006929108 0.2983276506 0.538766381 3 4493454 4493535 82 + 0.738 0.594 -0.613
ENSG00000150995 E007 3.9797287 0.006582687 0.2970964694 0.537555578 3 4493536 4493549 14 + 0.739 0.594 -0.613
ENSG00000150995 E008 4.5926311 0.006042718 0.2413060632 0.478054614 3 4493550 4493560 11 + 0.794 0.638 -0.643
ENSG00000150995 E009 5.3067793 0.016852456 0.1115383446 0.301596629 3 4493561 4493605 45 + 0.860 0.637 -0.903
ENSG00000150995 E010 5.7960680 0.009053676 0.0666277751 0.217477678 3 4494431 4494506 76 + 0.888 0.639 -1.004
ENSG00000150995 E011 3.2524562 0.150867948 0.5285881044 0.721018737 3 4516476 4516486 11 + 0.660 0.495 -0.747
ENSG00000150995 E012 2.9020980 0.107818267 0.3397251890 0.577745938 3 4516487 4516491 5 + 0.633 0.430 -0.960
ENSG00000150995 E013 5.7060907 0.037455350 0.2934263116 0.534117541 3 4516492 4516583 92 + 0.862 0.713 -0.592
ENSG00000150995 E014 6.2895448 0.055146139 0.5217808446 0.716154537 3 4521024 4521094 71 + 0.889 0.802 -0.337
ENSG00000150995 E015 0.1779838 0.034357438 0.7955506647   3 4521095 4521164 70 + 0.097 0.000 -13.076
ENSG00000150995 E016 0.0000000       3 4596140 4596184 45 +      
ENSG00000150995 E017 10.9342381 0.006948474 0.0010874538 0.010582469 3 4627763 4627878 116 + 1.174 0.809 -1.356
ENSG00000150995 E018 10.7041450 0.004442619 0.0085847457 0.051976444 3 4639384 4639470 87 + 1.143 0.862 -1.039
ENSG00000150995 E019 13.4434926 0.003078858 0.0006522279 0.007027236 3 4642093 4642251 159 + 1.247 0.910 -1.225
ENSG00000150995 E020 10.3917899 0.003020851 0.0051069894 0.035185373 3 4644136 4644234 99 + 1.136 0.836 -1.115
ENSG00000150995 E021 0.0000000       3 4644618 4645386 769 +      
ENSG00000150995 E022 9.2943845 0.008133771 0.0519139970 0.184215611 3 4645387 4645470 84 + 1.077 0.861 -0.805
ENSG00000150995 E023 9.6083330 0.003886124 0.4052814502 0.632517362 3 4645582 4645728 147 + 1.049 0.972 -0.283
ENSG00000150995 E024 1.0539076 0.039597493 0.8249633770   3 4645729 4649468 3740 + 0.301 0.265 -0.247
ENSG00000150995 E025 8.1557093 0.010307230 0.9322912418 0.968292238 3 4652123 4652218 96 + 0.952 0.952 0.002
ENSG00000150995 E026 3.6684602 0.007257881 0.7542192005 0.869256984 3 4653842 4653886 45 + 0.674 0.639 -0.153
ENSG00000150995 E027 13.3344374 0.002405731 0.2104976876 0.442405057 3 4658124 4658278 155 + 1.181 1.075 -0.380
ENSG00000150995 E028 11.1929359 0.003011415 0.0208121296 0.098709338 3 4660988 4661087 100 + 1.144 0.910 -0.860
ENSG00000150995 E029 13.4372448 0.005121773 0.0121018554 0.066865350 3 4662082 4662242 161 + 1.216 0.972 -0.881
ENSG00000150995 E030 13.8532214 0.021420623 0.6532834649 0.805618011 3 4663065 4663206 142 + 1.170 1.131 -0.140
ENSG00000150995 E031 14.1512218 0.003096619 0.8681467032 0.934943735 3 4665138 4665296 159 + 1.152 1.183 0.111
ENSG00000150995 E032 13.7817043 0.019805395 0.4987851110 0.699957303 3 4667377 4667549 173 + 1.168 1.109 -0.212
ENSG00000150995 E033 11.6410105 0.003681366 0.2953000231 0.535788541 3 4669654 4669773 120 + 1.120 1.027 -0.337
ENSG00000150995 E034 12.1665380 0.004904487 0.7503490034 0.866952974 3 4670729 4670885 157 + 1.120 1.104 -0.058
ENSG00000150995 E035 8.5401179 0.003659637 0.9489887698 0.976648506 3 4670886 4670926 41 + 0.964 0.972 0.029
ENSG00000150995 E036 0.7076135 0.021123966 0.0605991598   3 4671525 4671786 262 + 0.096 0.426 2.747
ENSG00000150995 E037 12.9016482 0.005375928 0.1419292008 0.350337108 3 4673136 4673293 158 + 1.188 1.058 -0.467
ENSG00000150995 E038 13.2295255 0.023327754 0.0978985125 0.278111751 3 4673294 4673387 94 + 1.208 1.037 -0.612
ENSG00000150995 E039 0.1614157 0.032970291 0.7958083895   3 4673388 4673442 55 + 0.096 0.000 -13.075
ENSG00000150995 E040 16.5483582 0.003210064 0.1611586963 0.378519195 3 4674202 4674343 142 + 1.277 1.170 -0.378
ENSG00000150995 E041 0.0000000       3 4674969 4675067 99 +      
ENSG00000150995 E042 12.9976943 0.017295486 0.1809747845 0.405238339 3 4675068 4675140 73 + 1.176 1.042 -0.485
ENSG00000150995 E043 15.6434600 0.006114399 0.3584799129 0.594570536 3 4675141 4675221 81 + 1.229 1.158 -0.251
ENSG00000150995 E044 2.0862738 0.288257551 0.6032779321 0.772394966 3 4675222 4675248 27 + 0.521 0.358 -0.859
ENSG00000150995 E045 1.5940864 0.018905190 0.2367222634 0.472807441 3 4675249 4676195 947 + 0.475 0.264 -1.245
ENSG00000150995 E046 18.5288358 0.001896938 0.6132972306 0.779149091 3 4676614 4676801 188 + 1.259 1.315 0.196
ENSG00000150995 E047 11.9566506 0.002786417 0.6415703212 0.797866052 3 4680553 4680677 125 + 1.120 1.089 -0.110
ENSG00000150995 E048 4.3686992 0.006155447 0.5216673157 0.716049761 3 4680678 4680691 14 + 0.757 0.678 -0.326
ENSG00000150995 E049 5.6375898 0.005521693 0.8388845656 0.918773235 3 4681364 4681418 55 + 0.794 0.836 0.165
ENSG00000150995 E050 10.8744556 0.003548071 0.8129191878 0.903975165 3 4683386 4683512 127 + 1.068 1.059 -0.034
ENSG00000150995 E051 8.7857264 0.026991619 0.6298469243 0.790369678 3 4683513 4683551 39 + 1.000 0.948 -0.193
ENSG00000150995 E052 15.8266698 0.037996458 0.8698751763 0.935784496 3 4683628 4683798 171 + 1.223 1.210 -0.048
ENSG00000150995 E053 9.5047964 0.023933750 0.8982206838 0.950889437 3 4684281 4684346 66 + 1.019 1.007 -0.043
ENSG00000150995 E054 7.2999168 0.008931450 0.5421323767 0.730588584 3 4685069 4685172 104 + 0.928 0.862 -0.251
ENSG00000150995 E055 5.2355628 0.008032823 0.9495956261 0.976849369 3 4685173 4685206 34 + 0.777 0.780 0.012
ENSG00000150995 E056 8.3229170 0.047920312 0.4876400408 0.692394795 3 4688495 4688620 126 + 0.992 0.885 -0.400
ENSG00000150995 E057 12.6729569 0.029644614 0.1901663918 0.417162399 3 4691144 4691323 180 + 1.177 1.022 -0.559
ENSG00000150995 E058 6.7856740 0.006049835 0.9039304522 0.953858217 3 4691324 4691344 21 + 0.887 0.886 -0.007
ENSG00000150995 E059 19.2912017 0.002187840 0.7600883219 0.872589902 3 4693490 4693741 252 + 1.299 1.288 -0.036
ENSG00000150995 E060 14.5509630 0.084703619 0.7903854823 0.890769710 3 4697147 4697272 126 + 1.165 1.197 0.113
ENSG00000150995 E061 6.6288590 0.102819935 0.7461366180 0.864462326 3 4699813 4699830 18 + 0.851 0.896 0.172
ENSG00000150995 E062 15.2285468 0.002422952 0.8979887119 0.950812324 3 4699831 4699941 111 + 1.202 1.206 0.014
ENSG00000150995 E063 16.5775307 0.002302750 0.7354216632 0.857553459 3 4702830 4702950 121 + 1.241 1.228 -0.047
ENSG00000150995 E064 9.1725525 0.004597603 0.6448904973 0.800131792 3 4706167 4706197 31 + 1.009 0.972 -0.137
ENSG00000150995 E065 14.5001725 0.002782671 0.8749631071 0.938712867 3 4706198 4706351 154 + 1.166 1.195 0.100
ENSG00000150995 E066 0.0000000       3 4709692 4709729 38 +      
ENSG00000150995 E067 11.2821505 0.003416400 0.8272933027 0.912247301 3 4710325 4710432 108 + 1.068 1.104 0.130
ENSG00000150995 E068 8.5483292 0.004315094 0.4840975403 0.689851808 3 4710433 4710473 41 + 0.998 0.931 -0.250
ENSG00000150995 E069 0.0000000       3 4711586 4711600 15 +      
ENSG00000150995 E070 0.0000000       3 4711601 4711756 156 +      
ENSG00000150995 E071 12.4569116 0.025090838 0.9023451575 0.953053688 3 4711757 4711868 112 + 1.127 1.116 -0.039
ENSG00000150995 E072 0.3751086 0.029949289 0.0970550119   3 4711869 4713831 1963 + 0.000 0.265 15.050
ENSG00000150995 E073 0.0000000       3 4717367 4717399 33 +      
ENSG00000150995 E074 0.0000000       3 4717400 4718226 827 +      
ENSG00000150995 E075 0.0000000       3 4724377 4724478 102 +      
ENSG00000150995 E076 0.1308682 0.032649190 0.3013937163   3 4725546 4725581 36 + 0.000 0.152 14.074
ENSG00000150995 E077 0.3337900 0.025294517 0.7165853194   3 4725582 4726869 1288 + 0.096 0.152 0.752
ENSG00000150995 E078 0.0000000       3 4727123 4727125 3 +      
ENSG00000150995 E079 0.3088520 0.025541882 0.7249434940   3 4727126 4727173 48 + 0.097 0.152 0.748
ENSG00000150995 E080 0.4231520 0.042868987 0.3361746676   3 4730383 4733087 2705 + 0.096 0.263 1.743
ENSG00000150995 E081 12.0300579 0.034066969 0.8173618006 0.906582412 3 4733088 4733220 133 + 1.100 1.129 0.104
ENSG00000150995 E082 14.2195892 0.006742949 0.5128179772 0.710091773 3 4735164 4735354 191 + 1.151 1.227 0.270
ENSG00000150995 E083 0.0000000       3 4735355 4735625 271 +      
ENSG00000150995 E084 0.7906259 0.385225543 0.1360897142   3 4737179 4738325 1147 + 0.095 0.428 2.772
ENSG00000150995 E085 15.3282243 0.002632900 0.1592157559 0.375579333 3 4766530 4766710 181 + 1.151 1.288 0.482
ENSG00000150995 E086 0.2027342 0.032776633 0.2993236480   3 4768267 4768510 244 + 0.000 0.152 14.080
ENSG00000150995 E087 22.1415323 0.001533309 0.2443881423 0.481503672 3 4768511 4768764 254 + 1.309 1.410 0.349
ENSG00000150995 E088 0.4952057 0.304555416 1.0000000000   3 4774632 4775241 610 + 0.176 0.153 -0.242
ENSG00000150995 E089 22.1961488 0.001673853 0.2796404978 0.519742459 3 4775242 4775428 187 + 1.374 1.307 -0.233
ENSG00000150995 E090 11.2224133 0.003383809 0.9519319964 0.977925869 3 4775429 4775442 14 + 1.068 1.089 0.077
ENSG00000150995 E091 16.5327632 0.006078317 0.6660203684 0.813715041 3 4777264 4777374 111 + 1.247 1.226 -0.076
ENSG00000150995 E092 0.0000000       3 4777375 4777810 436 +      
ENSG00000150995 E093 16.7617398 0.003112961 0.5322460827 0.723653707 3 4779550 4779645 96 + 1.202 1.270 0.240
ENSG00000150995 E094 0.0000000       3 4782340 4782618 279 +      
ENSG00000150995 E095 19.9129683 0.003649766 0.0813590179 0.247540750 3 4782619 4782741 123 + 1.235 1.389 0.540
ENSG00000150995 E096 0.0000000       3 4783296 4783367 72 +      
ENSG00000150995 E097 14.9404043 0.003207164 0.0428031970 0.162033109 3 4783816 4783920 105 + 1.103 1.298 0.689
ENSG00000150995 E098 22.3245061 0.003036877 0.1226168589 0.319923224 3 4787947 4788139 193 + 1.299 1.430 0.457
ENSG00000150995 E099 0.4054685 0.377512859 0.1621302562   3 4788140 4788458 319 + 0.000 0.274 14.657
ENSG00000150995 E100 0.1426347 0.031893451 0.7962012713   3 4795000 4795064 65 + 0.096 0.000 -13.073
ENSG00000150995 E101 16.4559718 0.002227305 0.3660915346 0.600834351 3 4795065 4795187 123 + 1.188 1.279 0.321
ENSG00000150995 E102 1.2429203 0.022910370 0.9863273948   3 4795188 4797790 2603 + 0.351 0.353 0.016
ENSG00000150995 E103 0.3641499 0.027422888 0.7201516452   3 4798730 4799124 395 + 0.096 0.152 0.754
ENSG00000150995 E104 0.1308682 0.032649190 0.3013937163   3 4799125 4799354 230 + 0.000 0.152 14.074
ENSG00000150995 E105 0.0000000       3 4799355 4799387 33 +      
ENSG00000150995 E106 0.3088520 0.025541882 0.7249434940   3 4799388 4799740 353 + 0.097 0.152 0.748
ENSG00000150995 E107 0.0000000       3 4799741 4799783 43 +      
ENSG00000150995 E108 0.0000000       3 4799784 4799794 11 +      
ENSG00000150995 E109 0.3040503 0.026641835 0.3824124395   3 4799795 4799981 187 + 0.175 0.000 -14.034
ENSG00000150995 E110 0.3040503 0.026641835 0.3824124395   3 4799982 4800003 22 + 0.175 0.000 -14.034
ENSG00000150995 E111 0.3040503 0.026641835 0.3824124395   3 4800004 4800031 28 + 0.175 0.000 -14.034
ENSG00000150995 E112 0.3040503 0.026641835 0.3824124395   3 4800032 4800204 173 + 0.175 0.000 -14.034
ENSG00000150995 E113 0.0000000       3 4800205 4800299 95 +      
ENSG00000150995 E114 0.0000000       3 4800300 4800424 125 +      
ENSG00000150995 E115 19.1002979 0.002041808 0.5542444590 0.739307508 3 4800425 4800600 176 + 1.271 1.332 0.215
ENSG00000150995 E116 0.0000000       3 4804169 4804197 29 +      
ENSG00000150995 E117 0.0000000       3 4804198 4804212 15 +      
ENSG00000150995 E118 0.0000000       3 4804213 4804241 29 +      
ENSG00000150995 E119 0.0000000       3 4804242 4804286 45 +      
ENSG00000150995 E120 0.0000000       3 4804287 4804442 156 +      
ENSG00000150995 E121 0.0000000       3 4804443 4804599 157 +      
ENSG00000150995 E122 0.0000000       3 4804600 4804745 146 +      
ENSG00000150995 E123 0.0000000       3 4804916 4805042 127 +      
ENSG00000150995 E124 19.1596917 0.002091434 0.0805191886 0.245900621 3 4806103 4806267 165 + 1.228 1.380 0.532
ENSG00000150995 E125 22.6846646 0.001914766 0.1044059704 0.289582138 3 4811265 4811460 196 + 1.309 1.444 0.465
ENSG00000150995 E126 0.0000000       3 4813047 4813141 95 +      
ENSG00000150995 E127 18.9222217 0.035722747 0.3083186392 0.548956101 3 4813142 4813234 93 + 1.235 1.370 0.472
ENSG00000150995 E128 0.1308682 0.032649190 0.3013937163   3 4814323 4814422 100 + 0.000 0.152 14.074
ENSG00000150995 E129 18.1256265 0.160610706 0.3930000620 0.622817024 3 4814423 4814527 105 + 1.207 1.366 0.557
ENSG00000150995 E130 12.1861495 0.182690596 0.6319544165 0.791678310 3 4814528 4814562 35 + 1.080 1.157 0.276
ENSG00000150995 E131 0.0000000       3 4814609 4814618 10 +      
ENSG00000150995 E132 0.0000000       3 4814619 4814638 20 +      
ENSG00000150995 E133 0.0000000       3 4814639 4814732 94 +      
ENSG00000150995 E134 0.0000000       3 4814733 4814763 31 +      
ENSG00000150995 E135 0.1614157 0.032970291 0.7958083895   3 4814764 4815052 289 + 0.096 0.000 -13.075
ENSG00000150995 E136 19.6793353 0.114497096 0.3208420178 0.560449594 3 4815053 4815218 166 + 1.242 1.393 0.526
ENSG00000150995 E137 24.5970099 0.025165563 0.0636920701 0.211026581 3 4818082 4818242 161 + 1.301 1.514 0.736
ENSG00000150995 E138 22.2247764 0.035535659 0.0982398748 0.278692853 3 4836774 4836935 162 + 1.247 1.472 0.783
ENSG00000150995 E139 0.3150090 0.026093792 0.7153120688   3 4836936 4836976 41 + 0.096 0.152 0.754
ENSG00000150995 E140 88.9288140 0.012521952 0.0086791988 0.052380240 3 4846139 4847506 1368 + 1.857 2.045 0.633