ENSG00000150779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504148 ENSG00000150779 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMM8B protein_coding protein_coding 142.8202 115.843 111.4696 22.04742 9.480793 -0.05551539 63.991710 67.238247 47.268916 22.4904944 3.6848129 -0.5082997 0.45452500 0.56936667 0.43656667 -0.13280000 8.341373e-01 1.193909e-09 FALSE  
ENST00000507614 ENSG00000150779 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMM8B protein_coding processed_transcript 142.8202 115.843 111.4696 22.04742 9.480793 -0.05551539 10.478607 5.227944 9.103224 0.8549298 3.8369223 0.7989610 0.07672500 0.04766667 0.07680000 0.02913333 9.331029e-01 1.193909e-09    
ENST00000509359 ENSG00000150779 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMM8B protein_coding nonsense_mediated_decay 142.8202 115.843 111.4696 22.04742 9.480793 -0.05551539 6.673916 2.636971 8.747817 0.5682732 0.1073487 1.7262292 0.04973333 0.02256667 0.07963333 0.05706667 1.193909e-09 1.193909e-09    
ENST00000541231 ENSG00000150779 HEK293_OSMI2_6hA HEK293_TMG_6hB TIMM8B protein_coding protein_coding 142.8202 115.843 111.4696 22.04742 9.480793 -0.05551539 61.675933 40.739839 46.349666 19.6140627 9.4463612 0.1860758 0.41901250 0.36040000 0.40703333 0.04663333 9.375451e-01 1.193909e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000150779 E001 3.718667 0.0078377536 3.326090e-05 5.896103e-04 11 112084800 112084816 17 - 0.960 0.346 -2.737
ENSG00000150779 E002 18.467065 0.0275565473 2.275364e-04 2.974666e-03 11 112084817 112085148 332 - 1.508 1.080 -1.502
ENSG00000150779 E003 1453.066423 0.0001156931 8.116497e-01 9.032601e-01 11 112085149 112085462 314 - 3.154 3.145 -0.031
ENSG00000150779 E004 2.106817 1.2948703710 5.985456e-01 7.692900e-01 11 112085967 112085977 11 - 0.425 0.509 0.424
ENSG00000150779 E005 127.605438 0.0062748658 6.143116e-14 7.957607e-12 11 112085978 112086310 333 - 2.302 1.913 -1.304
ENSG00000150779 E006 767.827624 0.0001588323 2.326971e-12 2.247737e-10 11 112086640 112086798 159 - 2.823 2.895 0.242