ENSG00000150627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443118 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding protein_coding 1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.02445597 0.00000000 0.0000000 0.00000000 0.0000000 0.000000 0.05602917 0.00000000 0.00000000 0.000000000   0.007044938 FALSE TRUE
ENST00000508596 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding protein_coding 1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.27802919 0.18392874 0.4465092 0.09885114 0.2317522 1.235117 0.14929583 0.28613333 0.12580000 -0.160333333 0.878773976 0.007044938 FALSE TRUE
MSTRG.25749.10 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding   1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.56206058 0.29259884 1.2631224 0.06926790 0.3058207 2.072893 0.26845000 0.45173333 0.32140000 -0.130333333 0.793123513 0.007044938 TRUE TRUE
MSTRG.25749.12 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding   1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.09025014 0.03488454 0.2328875 0.01795034 0.0884978 2.435998 0.06765000 0.05273333 0.05660000 0.003866667 0.987315660 0.007044938 FALSE TRUE
MSTRG.25749.3 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding   1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.50838242 0.00000000 0.9324993 0.00000000 0.1567052 6.558420 0.16562500 0.00000000 0.26206667 0.262066667 0.007044938 0.007044938 FALSE TRUE
MSTRG.25749.5 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding   1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.22916291 0.06944814 0.3973216 0.06944814 0.2479096 2.358083 0.13920417 0.10316667 0.11460000 0.011433333 0.942484846 0.007044938 FALSE TRUE
MSTRG.25749.6 ENSG00000150627 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR17 protein_coding   1.906505 0.6523659 3.856516 0.01066295 0.5598593 2.545334 0.08140605 0.00000000 0.1066985 0.00000000 0.1066985 3.544714 0.06541250 0.00000000 0.02183333 0.021833333 1.000000000 0.007044938 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000150627 E001 0.0000000       4 176065841 176065876 36 +      
ENSG00000150627 E002 0.0000000       4 176065877 176065882 6 +      
ENSG00000150627 E003 0.1779838 0.033202133 1.00000000   4 176065883 176065980 98 + 0.062 0.000 -8.850
ENSG00000150627 E004 1.7609239 0.011236055 0.99099805 0.99722841 4 176065981 176066079 99 + 0.375 0.374 -0.005
ENSG00000150627 E005 0.1779838 0.033202133 1.00000000   4 176068220 176068278 59 + 0.062 0.000 -10.341
ENSG00000150627 E006 0.3206185 0.027442404 1.00000000   4 176068279 176068348 70 + 0.116 0.000 -11.280
ENSG00000150627 E007 0.3040503 0.026873552 1.00000000   4 176068349 176068386 38 + 0.115 0.000 -11.279
ENSG00000150627 E008 0.3393995 0.027442404 1.00000000   4 176096463 176096484 22 + 0.116 0.000 -11.281
ENSG00000150627 E009 0.5173834 0.030030367 0.71069124   4 176096485 176096509 25 + 0.164 0.000 -11.823
ENSG00000150627 E010 1.1420522 0.014291826 0.19667220   4 176096510 176096585 76 + 0.315 0.000 -12.893
ENSG00000150627 E011 0.1426347 0.032142099 1.00000000   4 176111208 176111293 86 + 0.062 0.000 -10.338
ENSG00000150627 E012 6.1223867 0.033824247 0.22202570 0.45593149 4 176111575 176111703 129 + 0.799 0.573 -0.952
ENSG00000150627 E013 10.0630302 0.073148884 0.22894240 0.46391236 4 176115796 176115979 184 + 0.986 0.760 -0.871
ENSG00000150627 E014 14.5621675 0.013890736 0.61373250 0.77938139 4 176119867 176120097 231 + 1.108 1.050 -0.213
ENSG00000150627 E015 7.5794975 0.004350546 0.76603070 0.87625047 4 176125104 176125154 51 + 0.851 0.810 -0.157
ENSG00000150627 E016 11.4745503 0.002649841 0.49484928 0.69732387 4 176125155 176125355 201 + 1.013 0.930 -0.308
ENSG00000150627 E017 0.8433510 0.168866741 0.30310299   4 176126906 176126941 36 + 0.164 0.376 1.584
ENSG00000150627 E018 1.2892282 0.119909529 0.07247477   4 176126946 176126977 32 + 0.207 0.572 2.166
ENSG00000150627 E019 10.9604250 0.004283102 0.60155523 0.77116992 4 176128738 176128860 123 + 0.993 0.930 -0.237
ENSG00000150627 E020 19.4823135 0.001929423 0.12183358 0.31877581 4 176131554 176131738 185 + 1.234 1.077 -0.563
ENSG00000150627 E021 18.4922123 0.006318536 0.04630155 0.17079509 4 176135108 176135276 169 + 1.222 0.995 -0.817
ENSG00000150627 E022 9.8507902 0.005030258 0.43532965 0.65522456 4 176137520 176137611 92 + 0.958 0.854 -0.393
ENSG00000150627 E023 8.1835118 0.005174273 0.21370251 0.44602359 4 176139892 176139974 83 + 0.832 0.995 0.616
ENSG00000150627 E024 6.9819803 0.017933705 0.30680262 0.54742941 4 176141983 176142069 87 + 0.780 0.929 0.577
ENSG00000150627 E025 9.1295250 0.007905906 0.85686062 0.92874967 4 176145995 176146159 165 + 0.904 0.930 0.099
ENSG00000150627 E026 16.1859755 0.002055462 0.90218105 0.95295939 4 176148133 176148335 203 + 1.130 1.145 0.054
ENSG00000150627 E027 13.8734166 0.002325310 0.73049723 0.85451023 4 176149807 176149956 150 + 1.061 1.101 0.144
ENSG00000150627 E028 14.6921104 0.002850423 0.28844999 0.52915707 4 176150043 176150173 131 + 1.115 0.995 -0.438
ENSG00000150627 E029 9.0275551 0.003232241 0.66088681 0.81049851 4 176150468 176150490 23 + 0.912 0.854 -0.220
ENSG00000150627 E030 14.2321786 0.012693523 0.18688415 0.41289033 4 176150491 176150593 103 + 1.102 0.930 -0.633
ENSG00000150627 E031 17.0566718 0.027568833 0.56796082 0.74875781 4 176151812 176151967 156 + 1.166 1.097 -0.248
ENSG00000150627 E032 7.7354100 0.006663238 0.48395978 0.68975347 4 176156079 176156088 10 + 0.832 0.930 0.374
ENSG00000150627 E033 10.2861903 0.003214654 0.53220630 0.72362751 4 176156089 176156143 55 + 0.972 0.894 -0.296
ENSG00000150627 E034 12.7531797 0.002529864 0.70279485 0.83735320 4 176159994 176160126 133 + 1.031 1.077 0.164
ENSG00000150627 E035 9.6941390 0.020929461 0.97347020 0.98866523 4 176160911 176161002 92 + 0.928 0.931 0.010
ENSG00000150627 E036 12.3163330 0.026277379 0.54945275 0.73592234 4 176162075 176162174 100 + 1.003 1.078 0.271
ENSG00000150627 E037 1.8012624 0.013126994 0.98925425 0.99638879 4 176163058 176163153 96 + 0.375 0.374 -0.008
ENSG00000150627 E038 15.9836124 0.004821551 0.78075973 0.88517033 4 176163154 176163293 140 + 1.130 1.101 -0.106
ENSG00000150627 E039 0.0000000       4 176166124 176166144 21 +      
ENSG00000150627 E040 0.0000000       4 176168648 176168671 24 +      
ENSG00000150627 E041 12.0744982 0.002764530 0.70933557 0.84136432 4 176168672 176168783 112 + 1.006 1.051 0.165
ENSG00000150627 E042 0.1723744 0.032957932 0.09029456   4 176172331 176172374 44 + 0.000 0.226 13.620
ENSG00000150627 E043 17.8072600 0.002923419 0.98659420 0.99515059 4 176172375 176172516 142 + 1.164 1.167 0.010
ENSG00000150627 E044 17.6092573 0.019668577 0.88543100 0.94418137 4 176173267 176173369 103 + 1.158 1.168 0.036
ENSG00000150627 E045 15.8184762 0.003497218 0.95046761 0.97723892 4 176174617 176174718 102 + 1.116 1.124 0.029
ENSG00000150627 E046 16.0263061 0.031858719 0.51688217 0.71295383 4 176177058 176177156 99 + 1.110 1.185 0.270
ENSG00000150627 E047 19.3740508 0.003200105 0.27591988 0.51599293 4 176177471 176177654 184 + 1.185 1.289 0.364
ENSG00000150627 E048 14.2694059 0.049650948 0.68879053 0.82833286 4 176179460 176179632 173 + 1.073 1.140 0.244
ENSG00000150627 E049 53.7844230 0.006810186 0.01634727 0.08306332 4 176179633 176182818 3186 + 1.601 1.754 0.517
ENSG00000150627 E050 0.6412370 0.025652653 0.48559164   4 176183495 176183522 28 + 0.207 0.000 -12.192