ENSG00000150433

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279968 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding protein_coding 30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 3.683078 3.7222725 1.3395276 0.6496424 0.67241941 -1.4675998 0.12028333 0.14693333 0.05313333 -0.09380000 0.66554061 2.3836e-06 FALSE TRUE
ENST00000528724 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding protein_coding 30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 1.889361 3.0931969 0.8254153 0.1423778 0.49928983 -1.8931897 0.06099583 0.12390000 0.03200000 -0.09190000 0.44274624 2.3836e-06 FALSE TRUE
ENST00000531262 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding processed_transcript 30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 6.613195 4.1831218 7.4000792 0.7387561 0.23826857 0.8214642 0.21767083 0.16440000 0.29060000 0.12620000 0.02199957 2.3836e-06   FALSE
ENST00000531909 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding protein_coding 30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 1.942131 1.8531231 1.2035891 0.3668476 0.41309114 -0.6184430 0.06340000 0.07570000 0.04713333 -0.02856667 0.74859432 2.3836e-06 FALSE TRUE
ENST00000532156 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding protein_coding 30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 3.068460 2.6136488 2.0619332 0.3843589 0.45083235 -0.3405971 0.09925833 0.10726667 0.08090000 -0.02636667 0.84232406 2.3836e-06   FALSE
MSTRG.6511.12 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding   30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 1.931416 0.9322377 2.1390010 0.4066833 0.08211105 1.1895031 0.06392917 0.03836667 0.08403333 0.04566667 0.55724089 2.3836e-06 FALSE TRUE
MSTRG.6511.15 ENSG00000150433 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM218 protein_coding   30.43382 25.13637 25.47403 1.972646 0.2714969 0.01924312 1.373857 2.0237974 0.2612980 0.1820826 0.26129803 -2.9062255 0.04566250 0.08283333 0.01030000 -0.07253333 0.14068337 2.3836e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000150433 E001 28.439349 0.2873048592 0.70532016 0.83889249 11 125094389 125096544 2156 - 1.603 1.334 -0.926
ENSG00000150433 E002 12.513499 0.0616201385 0.44943401 0.66528074 11 125096545 125097034 490 - 1.207 1.068 -0.499
ENSG00000150433 E003 14.652487 0.0041332232 0.68551630 0.82618245 11 125097035 125097070 36 - 1.160 1.211 0.181
ENSG00000150433 E004 32.508654 0.1512209184 0.34825254 0.58571453 11 125097071 125097141 71 - 1.454 1.552 0.337
ENSG00000150433 E005 63.242730 0.3660416638 0.30572992 0.54638798 11 125097142 125097242 101 - 1.717 1.843 0.425
ENSG00000150433 E006 37.525978 0.1967916638 0.31750210 0.55746530 11 125097243 125097243 1 - 1.505 1.617 0.382
ENSG00000150433 E007 53.318825 0.3350770323 0.38208838 0.61393870 11 125097244 125097256 13 - 1.673 1.756 0.280
ENSG00000150433 E008 83.608989 0.4567670870 0.30966723 0.55012467 11 125097257 125097325 69 - 1.830 1.966 0.455
ENSG00000150433 E009 76.518152 0.4369479887 0.32761102 0.56668112 11 125097326 125097338 13 - 1.802 1.923 0.405
ENSG00000150433 E010 153.411617 0.9090603722 0.39622085 0.62535529 11 125097339 125097441 103 - 2.088 2.229 0.471
ENSG00000150433 E011 111.724683 0.5712132472 0.34652248 0.58412315 11 125097442 125097485 44 - 1.965 2.086 0.405
ENSG00000150433 E012 116.401755 0.5939548096 0.36196182 0.59732737 11 125097486 125097529 44 - 1.989 2.100 0.373
ENSG00000150433 E013 223.520230 1.0831982682 0.44261371 0.66045200 11 125097530 125097740 211 - 2.260 2.387 0.424
ENSG00000150433 E014 76.733564 0.1983887630 0.30018077 0.54060679 11 125101201 125101201 1 - 1.808 1.923 0.388
ENSG00000150433 E015 76.590929 0.1968669333 0.29520392 0.53571038 11 125101202 125101202 1 - 1.805 1.923 0.397
ENSG00000150433 E016 99.201485 0.0544395565 0.28543219 0.52602901 11 125101203 125101255 53 - 1.934 2.026 0.306
ENSG00000150433 E017 57.199277 0.0009022265 0.88344968 0.94304565 11 125101256 125101256 1 - 1.742 1.766 0.081
ENSG00000150433 E018 74.335680 0.0005535708 0.38369644 0.61531150 11 125101257 125101303 47 - 1.832 1.886 0.184
ENSG00000150433 E019 9.082541 0.0731241181 0.79210808 0.89166962 11 125101304 125101443 140 - 0.967 1.000 0.120
ENSG00000150433 E020 8.960323 0.1249428375 0.46017812 0.67324410 11 125101444 125101521 78 - 1.025 0.956 -0.254
ENSG00000150433 E021 24.287775 0.1991089053 0.08281720 0.25035629 11 125101522 125102131 610 - 1.548 1.249 -1.034
ENSG00000150433 E022 117.220370 0.0438827849 0.91281900 0.95850849 11 125102132 125102302 171 - 2.019 2.087 0.228
ENSG00000150433 E023 51.430163 0.0934704197 0.33973747 0.57774594 11 125102303 125102304 2 - 1.742 1.685 -0.193
ENSG00000150433 E024 56.328624 0.0832935229 0.39169980 0.62178924 11 125102305 125102317 13 - 1.768 1.733 -0.118
ENSG00000150433 E025 19.228489 0.0850392614 0.75137365 0.86764469 11 125102318 125102351 34 - 1.273 1.304 0.107
ENSG00000150433 E026 34.909631 0.1197805736 0.02493824 0.11203343 11 125102352 125102636 285 - 1.702 1.396 -1.048
ENSG00000150433 E027 53.450426 0.0976707611 0.12155095 0.31830113 11 125102637 125102729 93 - 1.818 1.653 -0.561
ENSG00000150433 E028 30.459789 0.1017673556 0.23974947 0.47638055 11 125102730 125102733 4 - 1.557 1.435 -0.420
ENSG00000150433 E029 97.382744 0.0886264733 0.22078661 0.45438691 11 125102734 125102809 76 - 2.035 1.944 -0.304
ENSG00000150433 E030 16.437712 0.1392480974 0.01636088 0.08311757 11 125102810 125105041 2232 - 1.425 1.034 -1.382
ENSG00000150433 E031 10.315019 0.0033107851 0.06921486 0.22322340 11 125110491 125110549 59 - 0.889 1.108 0.813
ENSG00000150433 E032 9.982860 0.0135373407 0.79123142 0.89117183 11 125110644 125110746 103 - 1.022 1.022 -0.001
ENSG00000150433 E033 49.806993 0.0918597662 0.61064614 0.77736286 11 125111539 125111584 46 - 1.688 1.698 0.035
ENSG00000150433 E034 37.180752 0.0939564573 0.16763216 0.38741006 11 125111585 125111586 2 - 1.649 1.511 -0.470
ENSG00000150433 E035 53.241555 0.0900881355 0.04391035 0.16485297 11 125111587 125111775 189 - 1.844 1.622 -0.753