ENSG00000150093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302278 ENSG00000150093 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGB1 protein_coding protein_coding 35.54685 8.630575 58.35224 1.593135 3.224571 2.755836 22.35888 8.175123 34.30957 1.562455 1.912936 2.067955 0.7612083 0.9444333 0.5893333 -0.3551 1.152034e-16 8.719357e-31 FALSE TRUE
MSTRG.3766.25 ENSG00000150093 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGB1 protein_coding   35.54685 8.630575 58.35224 1.593135 3.224571 2.755836 11.49752 0.000000 21.64465 0.000000 1.823108 11.080461 0.1857667 0.0000000 0.3701000 0.3701 8.719357e-31 8.719357e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000150093 E001 0.1308682 0.0308767874 6.474862e-02   10 32887273 32887331 59 - 0.000 0.247 12.521
ENSG00000150093 E002 9.1904961 0.0230172536 1.199216e-04 1.737210e-03 10 32887332 32889002 1671 - 0.749 1.255 1.883
ENSG00000150093 E003 1.1067030 0.0139750581 2.919327e-01   10 32900277 32900317 41 - 0.289 0.000 -15.249
ENSG00000150093 E004 0.7673035 0.0172671820 4.859882e-01   10 32900318 32900318 1 - 0.224 0.000 -14.733
ENSG00000150093 E005 1.0879220 0.0152662544 2.932879e-01   10 32900319 32900332 14 - 0.289 0.000 -15.229
ENSG00000150093 E006 5.0073296 0.1056375611 2.115544e-01 4.436148e-01 10 32900333 32900411 79 - 0.597 0.871 1.121
ENSG00000150093 E007 4.6867111 0.1265730090 1.835570e-01 4.085426e-01 10 32900412 32900413 2 - 0.566 0.873 1.270
ENSG00000150093 E008 4.6867111 0.1265730090 1.835570e-01 4.085426e-01 10 32900414 32900425 12 - 0.566 0.873 1.270
ENSG00000150093 E009 146.6814008 0.0025760626 3.426023e-08 1.421051e-06 10 32900426 32901254 829 - 1.980 2.212 0.779
ENSG00000150093 E010 91.9495712 0.0004674655 2.456342e-02 1.108893e-01 10 32901255 32901511 257 - 1.810 1.917 0.359
ENSG00000150093 E011 60.2934422 0.0007262349 1.416976e-01 3.500148e-01 10 32901512 32901563 52 - 1.634 1.720 0.293
ENSG00000150093 E012 69.4950527 0.0005731515 7.616783e-03 4.754834e-02 10 32901564 32901635 72 - 1.684 1.827 0.482
ENSG00000150093 E013 0.1426347 0.0320180403 1.000000e+00   10 32906010 32906318 309 - 0.055 0.000 -12.259
ENSG00000150093 E014 0.3453689 0.0275568676 2.051425e-01   10 32906319 32906464 146 - 0.055 0.248 2.512
ENSG00000150093 E015 0.7664957 0.0179951915 1.755727e-01   10 32906465 32906562 98 - 0.148 0.404 1.923
ENSG00000150093 E016 0.3150090 0.0324535862 2.047230e-01   10 32906563 32906580 18 - 0.055 0.248 2.511
ENSG00000150093 E017 0.9654734 0.1012422603 2.862880e-01   10 32906581 32907062 482 - 0.189 0.404 1.495
ENSG00000150093 E018 0.1614157 0.0339450972 1.000000e+00   10 32907063 32907143 81 - 0.055 0.000 -12.240
ENSG00000150093 E019 1.6676178 0.0115815410 6.555726e-01 8.070995e-01 10 32907144 32908367 1224 - 0.346 0.248 -0.662
ENSG00000150093 E020 58.6560036 0.0006754307 2.518793e-01 4.899313e-01 10 32908368 32908534 167 - 1.626 1.694 0.232
ENSG00000150093 E021 56.4431451 0.0006930598 1.087683e-01 2.970246e-01 10 32910223 32910455 233 - 1.604 1.701 0.328
ENSG00000150093 E022 90.2070793 0.0008023449 9.699496e-03 5.682343e-02 10 32911448 32911526 79 - 1.800 1.925 0.421
ENSG00000150093 E023 224.8753198 0.0002164336 1.337882e-04 1.906546e-03 10 32911527 32911670 144 - 2.192 2.307 0.384
ENSG00000150093 E024 390.7484153 0.0001517752 2.989712e-01 5.394184e-01 10 32911886 32912124 239 - 2.446 2.470 0.079
ENSG00000150093 E025 323.0343345 0.0001850367 5.263121e-01 7.194024e-01 10 32919885 32920084 200 - 2.366 2.382 0.053
ENSG00000150093 E026 299.8579170 0.0002321057 6.895621e-01 8.287522e-01 10 32920245 32920385 141 - 2.334 2.344 0.034
ENSG00000150093 E027 0.6682002 0.0264600734 5.804215e-01   10 32920386 32920397 12 - 0.148 0.248 0.927
ENSG00000150093 E028 3.8414701 0.0078237564 8.117942e-01 9.033327e-01 10 32920398 32921570 1173 - 0.569 0.611 0.187
ENSG00000150093 E029 1.1855836 0.0152594531 1.000000e+00   10 32921571 32921702 132 - 0.258 0.248 -0.077
ENSG00000150093 E030 2.2976358 0.0097257404 5.174612e-01 7.132974e-01 10 32921703 32922256 554 - 0.396 0.520 0.635
ENSG00000150093 E031 237.1359775 0.0002459176 6.980019e-01 8.342549e-01 10 32922257 32922346 90 - 2.233 2.245 0.037
ENSG00000150093 E032 215.6105250 0.0002589950 9.820663e-01 9.927761e-01 10 32922640 32922735 96 - 2.195 2.194 -0.001
ENSG00000150093 E033 0.2852693 0.2817618907 1.000000e+00   10 32922778 32923584 807 - 0.102 0.000 -12.377
ENSG00000150093 E034 269.1877450 0.0001907684 3.944324e-01 6.239336e-01 10 32923585 32923740 156 - 2.294 2.267 -0.089
ENSG00000150093 E035 198.0020675 0.0002989204 9.574263e-01 9.805681e-01 10 32925871 32925960 90 - 2.157 2.154 -0.010
ENSG00000150093 E036 261.8924701 0.0021699055 3.497142e-01 5.869923e-01 10 32925961 32926109 149 - 2.282 2.247 -0.117
ENSG00000150093 E037 169.1835871 0.0028851801 8.609118e-03 5.209289e-02 10 32928094 32928149 56 - 2.107 1.981 -0.422
ENSG00000150093 E038 179.4790083 0.0002599261 3.604759e-02 1.443603e-01 10 32928150 32928211 62 - 2.126 2.045 -0.270
ENSG00000150093 E039 162.7045007 0.0003300478 1.313335e-02 7.100072e-02 10 32928212 32928264 53 - 2.086 1.984 -0.341
ENSG00000150093 E040 121.4808215 0.0004107078 2.127084e-02 1.002158e-01 10 32929822 32929840 19 - 1.961 1.851 -0.370
ENSG00000150093 E041 149.6199669 0.0109266270 1.448384e-01 3.547236e-01 10 32929841 32929884 44 - 2.050 1.947 -0.345
ENSG00000150093 E042 125.8534782 0.0003906613 3.121272e-02 1.309543e-01 10 32929885 32929931 47 - 1.975 1.874 -0.338
ENSG00000150093 E043 120.5555493 0.0007244356 8.802772e-03 5.295289e-02 10 32929932 32929984 53 - 1.960 1.832 -0.430
ENSG00000150093 E044 120.0446784 0.0013996393 3.775417e-02 1.489736e-01 10 32929985 32930032 48 - 1.955 1.851 -0.349
ENSG00000150093 E045 89.5509948 0.0011156894 1.620579e-01 3.798275e-01 10 32930033 32930044 12 - 1.824 1.745 -0.265
ENSG00000150093 E046 0.0000000       10 32932506 32932510 5 -      
ENSG00000150093 E047 0.0000000       10 32932511 32932514 4 -      
ENSG00000150093 E048 84.6171404 0.0028340745 4.182313e-01 6.422979e-01 10 32932515 32932520 6 - 1.795 1.746 -0.167
ENSG00000150093 E049 128.9856123 0.0021177652 6.208634e-02 2.074736e-01 10 32932521 32932590 70 - 1.982 1.888 -0.317
ENSG00000150093 E050 67.7929548 0.0006519483 3.751329e-02 1.483368e-01 10 32932591 32932600 10 - 1.713 1.579 -0.454
ENSG00000150093 E051 0.1426347 0.0320180403 1.000000e+00   10 32932601 32933350 750 - 0.055 0.000 -12.259
ENSG00000150093 E052 0.9772399 0.0224007728 9.149762e-01   10 32933351 32933481 131 - 0.224 0.248 0.186
ENSG00000150093 E053 0.9640683 0.0151524893 3.715525e-01   10 32933482 32933583 102 - 0.258 0.000 -15.019
ENSG00000150093 E054 88.7002396 0.0005973476 1.686824e-01 3.888390e-01 10 32935492 32935558 67 - 1.821 1.745 -0.255
ENSG00000150093 E055 0.5587721 0.3770072642 5.529745e-01   10 32935895 32936081 187 - 0.144 0.243 0.931
ENSG00000150093 E056 0.9997774 0.0157657154 2.624842e-01   10 32936217 32936241 25 - 0.188 0.405 1.511
ENSG00000150093 E057 0.8571428 0.0171219017 1.750925e-01   10 32936242 32936349 108 - 0.148 0.405 1.925
ENSG00000150093 E058 0.4654660 0.0284228316 1.000000e+00   10 32936350 32936423 74 - 0.148 0.000 -13.868
ENSG00000150093 E059 0.4873834 0.4380756736 9.257974e-02   10 32938554 32938730 177 - 0.054 0.409 3.554
ENSG00000150093 E060 0.4654660 0.0284228316 1.000000e+00   10 32951675 32951758 84 - 0.148 0.000 -13.868
ENSG00000150093 E061 4.2710394 0.0097929462 5.692235e-01 7.496805e-01 10 32953593 32953809 217 - 0.628 0.519 -0.493
ENSG00000150093 E062 0.1723744 0.0440615281 6.484458e-02   10 32954459 32954490 32 - 0.000 0.248 14.346
ENSG00000150093 E063 0.0000000       10 32955570 32955663 94 -      
ENSG00000150093 E064 0.0000000       10 32957011 32957225 215 -      
ENSG00000150093 E065 0.2922838 0.0269026731 2.068173e-01   10 32957226 32957758 533 - 0.055 0.247 2.505
ENSG00000150093 E066 0.3040503 0.0274424043 1.000000e+00   10 32957759 32958144 386 - 0.104 0.000 -13.304
ENSG00000150093 E067 49.2171892 0.0077768635 3.174558e-01 5.574129e-01 10 32958145 32958325 181 - 1.544 1.622 0.266
ENSG00000150093 E068 0.1614157 0.0339450972 1.000000e+00   10 32958486 32958886 401 - 0.055 0.000 -12.240
ENSG00000150093 E069 0.0000000       10 32960290 32960324 35 -      
ENSG00000150093 E070 0.0000000       10 32960325 32960366 42 -      
ENSG00000150093 E071 0.0000000       10 32960367 32960503 137 -      
ENSG00000150093 E072 0.1779838 0.0355285962 1.000000e+00   10 32961108 32961160 53 - 0.055 0.000 -12.224
ENSG00000150093 E073 0.0000000       10 32963181 32963283 103 -      
ENSG00000150093 E074 0.0000000       10 32992331 32992463 133 -      
ENSG00000150093 E075 0.0000000       10 33005615 33005792 178 -