ENSG00000149930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279394 ENSG00000149930 HEK293_OSMI2_6hA HEK293_TMG_6hB TAOK2 protein_coding protein_coding 62.8858 91.95398 37.92404 5.141074 0.7771357 -1.277576 17.705507 25.015409 8.5355214 2.752858 0.51590476 -1.5501532 0.27507500 0.27143333 0.22490000 -0.04653333 0.6973332942 0.0001008219 FALSE TRUE
ENST00000308893 ENSG00000149930 HEK293_OSMI2_6hA HEK293_TMG_6hB TAOK2 protein_coding protein_coding 62.8858 91.95398 37.92404 5.141074 0.7771357 -1.277576 29.841475 46.447165 20.5063404 3.484236 1.13794378 -1.1791277 0.49318750 0.50420000 0.54010000 0.03590000 0.7939036941 0.0001008219 FALSE TRUE
ENST00000566552 ENSG00000149930 HEK293_OSMI2_6hA HEK293_TMG_6hB TAOK2 protein_coding retained_intron 62.8858 91.95398 37.92404 5.141074 0.7771357 -1.277576 6.575891 9.813066 0.9654219 1.401374 0.17724823 -3.3320751 0.08254167 0.10620000 0.02546667 -0.08073333 0.0001008219 0.0001008219 FALSE TRUE
ENST00000570844 ENSG00000149930 HEK293_OSMI2_6hA HEK293_TMG_6hB TAOK2 protein_coding retained_intron 62.8858 91.95398 37.92404 5.141074 0.7771357 -1.277576 4.122003 5.004764 3.6594328 2.639078 0.08535205 -0.4506247 0.06875417 0.05606667 0.09666667 0.04060000 0.5503457630 0.0001008219 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149930 E001 11.77055 0.0026006710 1.087943e-01 2.970572e-01 16 29973868 29973882 15 + 1.154 1.018 -0.495
ENSG00000149930 E002 16.78014 0.0024242733 1.958272e-02 9.448789e-02 16 29973883 29973886 4 + 1.326 1.150 -0.620
ENSG00000149930 E003 50.01050 0.0024272632 1.028583e-03 1.013278e-02 16 29973887 29973898 12 + 1.770 1.615 -0.523
ENSG00000149930 E004 334.48075 0.0001972706 2.920650e-03 2.292340e-02 16 29973899 29974181 283 + 2.501 2.467 -0.115
ENSG00000149930 E005 274.27745 0.0006895708 1.393401e-02 7.408859e-02 16 29974182 29974280 99 + 2.415 2.381 -0.114
ENSG00000149930 E006 551.49857 0.0004491957 6.887137e-01 8.282847e-01 16 29974281 29974648 368 + 2.674 2.697 0.076
ENSG00000149930 E007 458.22860 0.0006828659 5.781589e-02 1.979211e-01 16 29977738 29977904 167 + 2.619 2.609 -0.035
ENSG00000149930 E008 361.63563 0.0004381811 5.819602e-05 9.494689e-04 16 29978089 29978160 72 + 2.550 2.490 -0.201
ENSG00000149930 E009 452.87830 0.0003633552 4.979413e-07 1.541975e-05 16 29978252 29978353 102 + 2.654 2.584 -0.235
ENSG00000149930 E010 314.16952 0.0013752380 4.156538e-04 4.883601e-03 16 29978799 29978844 46 + 2.495 2.424 -0.234
ENSG00000149930 E011 447.86799 0.0021138682 7.854625e-04 8.158884e-03 16 29978974 29979070 97 + 2.646 2.579 -0.223
ENSG00000149930 E012 532.97684 0.0001795511 1.006260e-08 4.725834e-07 16 29979195 29979308 114 + 2.725 2.656 -0.232
ENSG00000149930 E013 472.03363 0.0001292428 6.186205e-07 1.869515e-05 16 29979417 29979508 92 + 2.668 2.608 -0.199
ENSG00000149930 E014 58.11724 0.1947376841 2.233837e-02 1.037118e-01 16 29980352 29981660 1309 + 1.947 1.593 -1.194
ENSG00000149930 E015 436.17323 0.0004170426 8.903824e-05 1.355812e-03 16 29981661 29981754 94 + 2.626 2.576 -0.166
ENSG00000149930 E016 388.46982 0.0001836442 1.507942e-03 1.367041e-02 16 29981859 29981940 82 + 2.565 2.531 -0.113
ENSG00000149930 E017 587.36817 0.0001421062 6.389870e-02 2.114710e-01 16 29982734 29982901 168 + 2.718 2.718 -0.002
ENSG00000149930 E018 744.07537 0.0001716192 3.600803e-01 5.957709e-01 16 29983072 29983332 261 + 2.787 2.833 0.151
ENSG00000149930 E019 593.29307 0.0010406975 2.900357e-01 5.306250e-01 16 29983503 29983664 162 + 2.682 2.737 0.182
ENSG00000149930 E020 18.80842 0.0854290123 1.726902e-01 3.940496e-01 16 29985118 29985212 95 + 1.348 1.201 -0.515
ENSG00000149930 E021 973.34638 0.0030074493 3.618875e-01 5.972538e-01 16 29985213 29985578 366 + 2.895 2.949 0.180
ENSG00000149930 E022 514.11522 0.0037384621 2.129972e-02 1.003156e-01 16 29985658 29985861 204 + 2.577 2.685 0.362
ENSG00000149930 E023 632.35852 0.0030969076 2.343170e-03 1.933548e-02 16 29986265 29986504 240 + 2.655 2.779 0.413
ENSG00000149930 E024 759.97726 0.0004569047 6.666958e-01 8.141244e-01 16 29986505 29986843 339 + 2.802 2.838 0.122
ENSG00000149930 E025 1636.86430 0.1188454378 6.026924e-02 2.034327e-01 16 29986844 29988358 1515 + 2.946 3.217 0.902
ENSG00000149930 E026 59.53140 0.1507938223 4.751901e-01 6.836745e-01 16 29988359 29988450 92 + 1.641 1.758 0.398
ENSG00000149930 E027 65.36349 0.0993620480 1.248684e-01 3.235360e-01 16 29989195 29989274 80 + 1.880 1.720 -0.539
ENSG00000149930 E028 335.17053 0.0039029023 4.979349e-01 6.994473e-01 16 29989593 29989805 213 + 2.470 2.473 0.009
ENSG00000149930 E029 107.79825 0.1882916191 5.031155e-02 1.804248e-01 16 29989910 29990542 633 + 2.151 1.902 -0.835
ENSG00000149930 E030 70.83299 0.1069099293 3.046854e-02 1.287514e-01 16 29990543 29990647 105 + 1.980 1.716 -0.891
ENSG00000149930 E031 52.65162 0.1566700863 5.803891e-02 1.983926e-01 16 29990648 29990783 136 + 1.835 1.601 -0.792
ENSG00000149930 E032 290.30291 0.0007495157 3.710521e-01 6.047678e-01 16 29990784 29990966 183 + 2.371 2.425 0.180
ENSG00000149930 E033 688.45090 0.0004135614 1.084783e-06 3.050017e-05 16 29991047 29992261 1215 + 2.696 2.815 0.398