ENSG00000149503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000278849 ENSG00000149503 HEK293_OSMI2_6hA HEK293_TMG_6hB INCENP protein_coding protein_coding 36.87599 42.1917 41.29078 2.507566 1.715319 -0.03113213 22.0602751 28.0352865 20.500690 1.44640256 1.2194256 -0.4513823 0.603591667 0.666233333 0.50080000 -0.16543333 0.2555702473 0.0008564623 FALSE TRUE
ENST00000528037 ENSG00000149503 HEK293_OSMI2_6hA HEK293_TMG_6hB INCENP protein_coding retained_intron 36.87599 42.1917 41.29078 2.507566 1.715319 -0.03113213 1.3231138 0.1443658 3.262459 0.07800314 1.0819822 4.4059502 0.033462500 0.003566667 0.07726667 0.07370000 0.0008564623 0.0008564623 FALSE TRUE
ENST00000531099 ENSG00000149503 HEK293_OSMI2_6hA HEK293_TMG_6hB INCENP protein_coding processed_transcript 36.87599 42.1917 41.29078 2.507566 1.715319 -0.03113213 0.3751022 0.0000000 3.000818 0.00000000 1.5366655 8.2340115 0.008716667 0.000000000 0.06973333 0.06973333 0.2888817774 0.0008564623   FALSE
MSTRG.5589.5 ENSG00000149503 HEK293_OSMI2_6hA HEK293_TMG_6hB INCENP protein_coding   36.87599 42.1917 41.29078 2.507566 1.715319 -0.03113213 6.3628197 1.4262055 9.893319 1.16442411 0.5488276 2.7856499 0.172737500 0.037100000 0.23996667 0.20286667 0.2025503621 0.0008564623 FALSE TRUE
MSTRG.5589.6 ENSG00000149503 HEK293_OSMI2_6hA HEK293_TMG_6hB INCENP protein_coding   36.87599 42.1917 41.29078 2.507566 1.715319 -0.03113213 4.3169003 11.1676531 1.750789 2.64935150 0.9890951 -2.6663234 0.118204167 0.258933333 0.04396667 -0.21496667 0.3911314230 0.0008564623 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149503 E001 0.1308682 3.088080e-02 6.644397e-01   11 62123998 62124002 5 + 0.000 0.103 9.002
ENSG00000149503 E002 0.3032425 2.444117e-02 3.137162e-01   11 62124003 62124005 3 + 0.000 0.186 12.448
ENSG00000149503 E003 0.3032425 2.444117e-02 3.137162e-01   11 62124006 62124009 4 + 0.000 0.186 12.448
ENSG00000149503 E004 0.6426420 1.938749e-02 7.242859e-01   11 62124010 62124010 1 + 0.250 0.186 -0.542
ENSG00000149503 E005 105.2794608 7.545104e-04 2.506497e-02 0.1124332048 11 62124011 62124055 45 + 2.068 1.979 -0.301
ENSG00000149503 E006 267.5650698 1.681381e-03 2.988035e-01 0.5392816175 11 62124056 62124163 108 + 2.443 2.404 -0.129
ENSG00000149503 E007 389.7504092 2.024288e-04 4.114442e-03 0.0298053535 11 62128151 62128301 151 + 2.619 2.557 -0.207
ENSG00000149503 E008 293.6267348 1.955864e-04 4.191039e-03 0.0302171538 11 62128770 62128883 114 + 2.502 2.433 -0.230
ENSG00000149503 E009 901.8860353 9.895759e-05 1.610666e-03 0.0144022828 11 62129782 62130558 777 + 2.975 2.929 -0.153
ENSG00000149503 E010 179.0317581 4.833952e-03 8.555455e-01 0.9279579134 11 62130559 62130590 32 + 2.245 2.244 -0.004
ENSG00000149503 E011 220.7378417 7.738851e-03 3.248609e-01 0.5640698684 11 62137832 62137883 52 + 2.370 2.313 -0.190
ENSG00000149503 E012 1.4077326 5.327430e-02 3.911430e-02 0.1524590085 11 62137884 62137976 93 + 0.570 0.186 -2.348
ENSG00000149503 E013 229.4961513 3.969807e-03 1.378757e-01 0.3442627439 11 62138713 62138770 58 + 2.394 2.328 -0.221
ENSG00000149503 E014 345.0338398 7.939375e-04 4.256801e-02 0.1614162569 11 62138888 62139005 118 + 2.564 2.509 -0.185
ENSG00000149503 E015 266.7878446 1.629483e-03 3.682981e-01 0.6026273160 11 62140234 62140285 52 + 2.441 2.407 -0.114
ENSG00000149503 E016 326.1011143 1.384693e-03 4.291601e-01 0.6503862040 11 62140704 62140821 118 + 2.501 2.513 0.039
ENSG00000149503 E017 300.9529984 2.195452e-03 6.046490e-01 0.7732759068 11 62140913 62141044 132 + 2.470 2.477 0.022
ENSG00000149503 E018 21.6436427 1.565476e-03 4.713295e-03 0.0330779771 11 62141500 62141511 12 + 1.209 1.422 0.745
ENSG00000149503 E019 10.2216419 4.900998e-02 9.167760e-01 0.9605485676 11 62141512 62141745 234 + 1.050 1.028 -0.080
ENSG00000149503 E020 304.6371662 1.220211e-03 2.376750e-01 0.4738850129 11 62144982 62145091 110 + 2.466 2.489 0.076
ENSG00000149503 E021 334.7374711 5.991740e-04 1.090987e-02 0.0619875991 11 62145169 62145289 121 + 2.490 2.538 0.161
ENSG00000149503 E022 342.0933461 1.689384e-04 7.628159e-05 0.0011925221 11 62145629 62145751 123 + 2.485 2.556 0.235
ENSG00000149503 E023 54.5987712 1.945342e-03 8.279769e-01 0.9126103579 11 62145752 62145763 12 + 1.738 1.742 0.013
ENSG00000149503 E024 342.2036853 5.193176e-03 1.905355e-04 0.0025700803 11 62146658 62146902 245 + 2.438 2.580 0.473
ENSG00000149503 E025 164.2393022 4.753379e-03 9.747221e-06 0.0002050926 11 62148476 62148554 79 + 2.089 2.279 0.638
ENSG00000149503 E026 235.2738728 2.335522e-03 2.160656e-04 0.0028528149 11 62148739 62148846 108 + 2.295 2.409 0.383
ENSG00000149503 E027 366.6132132 4.304587e-04 2.697945e-05 0.0004922008 11 62150057 62150207 151 + 2.511 2.589 0.262
ENSG00000149503 E028 827.6869374 5.897154e-04 4.804772e-05 0.0008039394 11 62151762 62152481 720 + 2.875 2.931 0.186
ENSG00000149503 E029 156.7823014 1.813070e-02 4.009354e-02 0.1549568781 11 62152482 62152551 70 + 2.274 2.120 -0.513
ENSG00000149503 E030 168.5582875 1.641148e-02 7.990908e-02 0.2446439360 11 62152552 62152672 121 + 2.290 2.166 -0.416
ENSG00000149503 E031 488.5974401 1.249240e-02 1.572477e-03 0.0141285361 11 62152673 62153224 552 + 2.779 2.600 -0.595