ENSG00000149294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316851 ENSG00000149294 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAM1 protein_coding protein_coding 11.1367 10.07307 10.2163 1.228821 0.04021774 0.02034834 5.6351440 5.9787351 4.6985152 1.0965747 0.07443078 -0.3469791 0.5238750 0.58383333 0.45993333 -0.12390000 0.33460239 0.02463128 FALSE TRUE
ENST00000531044 ENSG00000149294 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAM1 protein_coding protein_coding 11.1367 10.07307 10.2163 1.228821 0.04021774 0.02034834 1.9035786 0.1656258 2.8175974 0.1656258 0.17621719 4.0090002 0.1471000 0.01620000 0.27566667 0.25946667 0.02463128 0.02463128 FALSE TRUE
ENST00000618266 ENSG00000149294 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAM1 protein_coding protein_coding 11.1367 10.07307 10.2163 1.228821 0.04021774 0.02034834 0.8380192 1.1809502 0.3541805 0.2677355 0.12754178 -1.7093876 0.0816875 0.11413333 0.03473333 -0.07940000 0.09236015 0.02463128 FALSE TRUE
MSTRG.6332.14 ENSG00000149294 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAM1 protein_coding   11.1367 10.07307 10.2163 1.228821 0.04021774 0.02034834 1.0031919 0.8389889 1.0258054 0.1182261 0.47976693 0.2869355 0.0902750 0.08766667 0.10020000 0.01253333 1.00000000 0.02463128 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149294 E001 0.2027342 0.0326477216 6.032324e-01   11 112961247 112961274 28 + 0.000 0.111 9.750
ENSG00000149294 E002 0.3641499 0.0274939468 8.594096e-01   11 112961275 112961367 93 + 0.133 0.111 -0.292
ENSG00000149294 E003 0.6979399 0.1420858465 8.485930e-01   11 112961368 112961401 34 + 0.234 0.202 -0.277
ENSG00000149294 E004 1.1741770 0.0152354753 9.516300e-01   11 112961402 112961419 18 + 0.316 0.336 0.123
ENSG00000149294 E005 1.1741770 0.0152354753 9.516300e-01   11 112961420 112961424 5 + 0.316 0.336 0.123
ENSG00000149294 E006 1.1741770 0.0152354753 9.516300e-01   11 112961425 112961429 5 + 0.316 0.336 0.123
ENSG00000149294 E007 1.9546520 0.0302285028 3.581097e-01 0.5942998391 11 112961430 112961433 4 + 0.543 0.391 -0.771
ENSG00000149294 E008 2.8772435 0.1574387508 7.982910e-01 0.8953181933 11 112961434 112961434 1 + 0.541 0.605 0.289
ENSG00000149294 E009 5.0333446 0.0715195922 9.694021e-01 0.9865440133 11 112961435 112961435 1 + 0.774 0.780 0.022
ENSG00000149294 E010 6.1767864 0.0489940453 5.851812e-01 0.7604237839 11 112961436 112961436 1 + 0.800 0.890 0.351
ENSG00000149294 E011 8.9571581 0.0688816523 2.421197e-01 0.4789458667 11 112961437 112961438 2 + 0.886 1.072 0.691
ENSG00000149294 E012 10.4403069 0.1249432956 2.131409e-01 0.4454238385 11 112961439 112961444 6 + 0.922 1.145 0.818
ENSG00000149294 E013 14.1672192 0.3027614168 5.180330e-01 0.7136453860 11 112961445 112961479 35 + 1.126 1.220 0.336
ENSG00000149294 E014 42.1964101 0.0154389571 2.228638e-01 0.4568202738 11 112961480 112961660 181 + 1.680 1.597 -0.281
ENSG00000149294 E015 17.7352592 0.0167836179 7.419278e-02 0.2331260158 11 112961661 112961664 4 + 1.351 1.192 -0.556
ENSG00000149294 E016 0.0000000       11 113003846 113003856 11 +      
ENSG00000149294 E017 0.1779838 0.0338267901 3.887368e-01   11 113040926 113041216 291 + 0.133 0.000 -13.141
ENSG00000149294 E018 0.0000000       11 113130694 113130799 106 +      
ENSG00000149294 E019 0.0000000       11 113132928 113133434 507 +      
ENSG00000149294 E020 0.0000000       11 113133435 113133448 14 +      
ENSG00000149294 E021 0.1614157 0.0322673977 3.891316e-01   11 113133449 113133951 503 + 0.133 0.000 -13.158
ENSG00000149294 E022 17.0446937 0.0192830890 1.952451e-01 0.4236493136 11 113202379 113202385 7 + 1.314 1.200 -0.402
ENSG00000149294 E023 28.1015077 0.0162569826 1.983965e-01 0.4276105187 11 113202386 113202453 68 + 1.510 1.417 -0.319
ENSG00000149294 E024 69.0146733 0.0006599448 8.635604e-03 0.0522099134 11 113204286 113204504 219 + 1.889 1.794 -0.321
ENSG00000149294 E025 73.8810434 0.0007253423 2.711104e-05 0.0004941564 11 113205523 113205666 144 + 1.951 1.794 -0.529
ENSG00000149294 E026 79.5448889 0.0005313930 1.273012e-03 0.0119598796 11 113206043 113206180 138 + 1.963 1.852 -0.371
ENSG00000149294 E027 65.3829722 0.0047708412 1.280728e-02 0.0696592355 11 113207261 113207378 118 + 1.882 1.767 -0.389
ENSG00000149294 E028 78.0930080 0.0005510810 3.451277e-03 0.0260526374 11 113207833 113208002 170 + 1.949 1.849 -0.336
ENSG00000149294 E029 63.1548447 0.0034973749 1.631274e-03 0.0145398549 11 113214369 113214511 143 + 1.878 1.734 -0.483
ENSG00000149294 E030 12.5898005 0.0662796388 1.067471e-01 0.2935678348 11 113221296 113221325 30 + 1.246 1.016 -0.826
ENSG00000149294 E031 2.7051928 0.0330378391 8.449048e-01 0.9220760985 11 113221326 113221903 578 + 0.545 0.591 0.209
ENSG00000149294 E032 1.8938466 0.0114857867 7.424258e-02 0.2332414186 11 113231196 113231273 78 + 0.234 0.560 1.880
ENSG00000149294 E033 1.7684003 0.0161006430 1.189687e-01 0.3141800101 11 113231380 113231644 265 + 0.234 0.524 1.711
ENSG00000149294 E034 59.7602934 0.0115541144 5.209387e-01 0.7155278693 11 113231645 113231795 151 + 1.793 1.770 -0.077
ENSG00000149294 E035 49.9913571 0.0041507328 8.408022e-01 0.9198820622 11 113232170 113232261 92 + 1.687 1.717 0.104
ENSG00000149294 E036 43.0585998 0.0061540150 4.184658e-01 0.6424720222 11 113232262 113232324 63 + 1.660 1.628 -0.108
ENSG00000149294 E037 38.1432079 0.0014625082 6.425818e-01 0.7985976009 11 113232325 113232354 30 + 1.594 1.583 -0.035
ENSG00000149294 E038 54.8650584 0.0007055356 3.682189e-01 0.6025746734 11 113232718 113232792 75 + 1.757 1.730 -0.089
ENSG00000149294 E039 30.3840165 0.0012427896 5.344696e-01 0.7252341814 11 113232793 113232794 2 + 1.506 1.483 -0.079
ENSG00000149294 E040 35.2990180 0.0010416101 3.374431e-01 0.5758140891 11 113232795 113232814 20 + 1.578 1.538 -0.136
ENSG00000149294 E041 67.2326053 0.0010323013 5.901625e-01 0.7638449107 11 113233147 113233257 111 + 1.832 1.825 -0.021
ENSG00000149294 E042 49.6555969 0.0008949898 9.977354e-01 1.0000000000 11 113233258 113233317 60 + 1.689 1.706 0.058
ENSG00000149294 E043 65.4909473 0.0010142857 5.219619e-01 0.7162804726 11 113235033 113235164 132 + 1.791 1.836 0.155
ENSG00000149294 E044 0.3150090 0.0274985766 8.629913e-01   11 113236301 113236315 15 + 0.133 0.111 -0.292
ENSG00000149294 E045 1.2499349 0.0136968632 7.348961e-01   11 113240507 113240785 279 + 0.386 0.335 -0.297
ENSG00000149294 E046 0.8211734 0.4150429290 9.824700e-01   11 113240786 113240833 48 + 0.232 0.277 0.337
ENSG00000149294 E047 0.9388700 0.0193841709 7.750484e-01   11 113242805 113242846 42 + 0.316 0.273 -0.294
ENSG00000149294 E048 1.6681814 0.3777949859 5.448443e-02 0.1901971026 11 113243552 113243790 239 + 0.632 0.112 -3.482
ENSG00000149294 E049 0.7962354 0.0188367547 8.580904e-01   11 113246108 113246367 260 + 0.234 0.273 0.290
ENSG00000149294 E050 32.1466288 0.0014027406 6.842684e-01 0.8254573811 11 113246368 113246370 3 + 1.492 1.534 0.145
ENSG00000149294 E051 0.4952057 0.2662705283 5.217118e-01   11 113255874 113255876 3 + 0.235 0.112 -1.289
ENSG00000149294 E052 50.3838709 0.0013696184 7.572739e-01 0.8710316908 11 113255877 113255949 73 + 1.708 1.708 0.002
ENSG00000149294 E053 43.4186273 0.0010477980 9.138943e-01 0.9590793972 11 113255950 113256001 52 + 1.631 1.653 0.075
ENSG00000149294 E054 0.0000000       11 113260091 113260142 52 +      
ENSG00000149294 E055 4.3998398 0.1143493620 6.403041e-01 0.7970884126 11 113260143 113260145 3 + 0.776 0.685 -0.369
ENSG00000149294 E056 41.5413147 0.0008982318 5.084718e-01 0.7068268583 11 113260146 113260180 35 + 1.597 1.650 0.180
ENSG00000149294 E057 71.3166141 0.0297691502 7.553238e-01 0.8698652881 11 113260181 113260323 143 + 1.840 1.870 0.102
ENSG00000149294 E058 0.3503582 0.0268888693 8.597407e-01   11 113260324 113260387 64 + 0.133 0.111 -0.295
ENSG00000149294 E059 0.1308682 0.0326491905 6.049895e-01   11 113262846 113262902 57 + 0.000 0.111 12.025
ENSG00000149294 E060 8.9572432 0.1262939659 9.576648e-03 0.0563037938 11 113262903 113265197 2295 + 0.625 1.162 2.073
ENSG00000149294 E061 2.4001987 0.2282335290 3.876185e-01 0.6185998988 11 113269969 113270187 219 + 0.385 0.606 1.090
ENSG00000149294 E062 83.1953229 0.8660498254 4.584213e-01 0.6720633979 11 113270188 113270395 208 + 1.836 1.981 0.489
ENSG00000149294 E063 69.1598080 0.0084272410 5.958272e-02 0.2018259754 11 113271760 113271876 117 + 1.770 1.899 0.434
ENSG00000149294 E064 1.9013227 0.2133367530 9.244841e-01 0.9645658148 11 113272933 113273048 116 + 0.447 0.478 0.160
ENSG00000149294 E065 4.2864445 0.1802453066 5.516213e-01 0.7374427809 11 113273049 113273748 700 + 0.625 0.790 0.682
ENSG00000149294 E066 72.3761998 0.0007334098 2.087916e-01 0.4404070856 11 113275267 113275390 124 + 1.822 1.892 0.235
ENSG00000149294 E067 366.3680291 0.0025826242 6.544021e-01 0.8063306604 11 113275391 113276716 1326 + 2.555 2.563 0.027
ENSG00000149294 E068 298.0846961 0.0012510321 1.557313e-05 0.0003080218 11 113276717 113277981 1265 + 2.394 2.522 0.425
ENSG00000149294 E069 90.9092483 0.0375581155 3.771446e-04 0.0045078702 11 113277982 113278441 460 + 1.720 2.087 1.236